U.S. Department of Health and Human Services
Deborah Hinton

 Contact Info

Tel: 301-496-9885
Email: dhinton@helix.nih.gov

 Select Experience

  • Ph.D.University of Illinois1980
  • M.S.University of Illinois1976
  • B.S.University of North Carolina at Chapel Hill1974

 Related Links

  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Hinton DM. A 3D puzzle approach to building protein-DNA structures. Transcription. 2017 Feb 2; 8 (8; 2; 2017 Feb 2):113-119. [Full Text/Abstract]
James TD, Cardozo T, Abell LE, Hsieh ML, Jenkins LM, Jha SS, Hinton DM. Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase. Nucleic Acids Res. 2016 Jul 25; 44 (16; 44; 2016 Jul 25):7974-7988. [Full Text/Abstract]
Chen Q, Boulanger A, Hinton DM, Stibitz S. Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in Bordetella pertussis. Mol Microbiol. 2014 Aug; 93 (93; 2014 Aug; 4):748-58. [Full Text/Abstract]
Hsieh ML, James TD, Knipling L, Waddell MB, White S, Hinton DM. Architecture of the Bacteriophage T4 Activator MotA/Promoter DNA Interaction During Sigma Appropriation. J Biol Chem. 2013 Sep 20; 288 (38; 288; 2013 Sep 20):27607-18. [Full Text/Abstract]
Boulanger A, Chen Q, Hinton DM, Stibitz S. In vivo phosphorylation dynamics of the Bordetella pertussis virulence-controlling response regulator BvgA. Mol Microbiol. 2013 Apr; 88 (2013 Apr; 1; 88):156-72. [Full Text/Abstract]
Decker KB, Hinton DM. Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases. Annu Rev Microbiol. 2013; 67 (67; 2013):113-39. [Full Text/Abstract]
Decker KB, James TD, Stibitz S, Hinton DM. The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA. Microbiology. 2012 Jul; 158 (Pt 7; 2012 Jul; 158):1665-76. [Full Text/Abstract]
Dolezal D, Jones CE, Lai X, Brister JR, Mueser TC, Nossal NG, Hinton DM. Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA. J Biol Chem. 2012 May 25; 287 (2012 May 25; 287; 22):18596-607. [Full Text/Abstract]
Bonocora RP, Decker PK, Glass S, Knipling L, Hinton DM. Bacteriophage T4 MotA activator and the β-flap tip of RNA polymerase target the same set of σ70 carboxyl-terminal residues. J Biol Chem. 2011 Nov 11; 286 (2011 Nov 11; 45; 286):39290-6. [Full Text/Abstract]
Decker KB, Chen Q, Hsieh ML, Boucher P, Stibitz S, Hinton DM. Different requirements for σ Region 4 in BvgA activation of the Bordetella pertussis promoters P(fim3) and P(fhaB). J Mol Biol. 2011 Jun 24; 409 (2011 Jun 24; 409; 5):692-709. [Full Text/Abstract]
James TD, Cashel M, Hinton DM. A mutation within the β subunit of Escherichia coli RNA polymerase impairs transcription from bacteriophage T4 middle promoters. J Bacteriol. 2010 Nov; 192 (2010 Nov; 21; 192):5580-7. [Full Text/Abstract]
Hinton DM. Transcriptional control in the prereplicative phase of T4 development. Virol J. 2010 Oct 28; 7 (7; 2010 Oct 28):289. [Full Text/Abstract]
Chen Q, Decker KB, Boucher PE, Hinton D, Stibitz S. Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA. Mol Microbiol. 2010 Sep; 77 (77; 2010 Sep; 5):1326-40. [Full Text/Abstract]
Hook-Barnard IG, Hinton DM. The promoter spacer influences transcription initiation via sigma70 region 1.1 of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A. 2009 Jan 20; 106 (106; 2009 Jan 20; 3):737-42. [Full Text/Abstract]