U.S. Department of Health and Human Services
Douglas Forrest

 Contact Info

Tel: 301-594-6170
Email: df189j@nih.gov

 Select Experience

  • Senior InvestigatorNIDDK, NIH2004
  • Associate ProfessorMount Sinai School of Medicine, Department of Human Genetics1995–2004
  • Ph.D.Glasgow University1987

 Related Links

  • Developmental Biology
  • Endocrinology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Neuroscience/Neurophysiology/Neurodevelopment

​Research Images

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Expression of thyroid hormone receptor ß in the anterior pituitary gland (left) and inner ear (right)Thyroid hormone receptor  regulates production of pituitary thyrotropin, which in turn regulates thyroid gland activity. TR is also required for the development of the cochlea (c) and the developmental onset of hearing. Picture by Iwan JonesExpression of thyroid hormone receptor ß in the anterior pituitary gland (left) and inner ear (right)Enlarge
The ossicles of the mouse middle earThe ossicles consist of three bones, the malleus, incus, and stapes (blue, immature cartilage; red, calcified bone). The ossicles in the middle ear relay the mechanical energy of sound from the outer ear to the inner ear. The development of the the ossicles is influenced by thyroid hormone. Picture by Emily CordasThe ossicles of the mouse middle earEnlarge
Cone photoreceptors in the retinaCones are the sensory cells that mediate color perception. In most mammals, cones express opsins for sensitivity to short (S, blue) or medium (M, green) wavelengths of light. Thyroid hormone receptor TR2 is essential for the differential expression of M and S opsins. Picture by Lily NgCone photoreceptors in the retinaEnlarge
Amacrine neurons in the mouse retinaAmacrine neurons integrate visual information as it is relayed form the retina to the optic nerve. The development of these neurons is critically dependent upon the Rorb orphan nuclear receptor gene. Picture by Hong LiuAmacrine neurons in the mouse retinaEnlarge