U.S. Department of Health and Human Services
Marius Clore

 Contact Info

Tel: 301-496-0782
Email: mariusc@mail.nih.gov

 Select Experience

  • NIH InvestigatorNIDDK, NIH1988 - present
  • Head, Biological NMR GroupMax Planck Institute for Biochemistry, Martinsried, Germany1984-1988
  • Member of Scientific StaffMRC National Institute for Medical Research, London, U.K.1980-1984
  • House SurgeonSt Charles Hospital (St. Mary's Group)1980
  • House PhysicianUniversity College Hospital1979-1980
  • Ph.D.MRC National Institute for Medical Research, London1982
  • M.D.University College Hospital Medical School, London1979
  • B.Sc. (1st class honors)University College London1976

 Related Links


G. Marius Clore, M.D., Ph.D., NIH Distinguished Investigator

Section Chief, Protein Nuclear Magnetic Resonance SectionLaboratory of Chemical Physics
  • Biomedical Engineering/Biophysics/Physics
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Wälti MA, Schmidt T, Murray DT, Wang H, Hinshaw JE, Clore GM. Chaperonin GroEL accelerates protofibril formation and decorates fibrils of the Het-s prion protein. Proc Natl Acad Sci U S A. 2017 Aug 7; 114 (2017 Aug 7; 114; 34):9104-9109. [Full Text/Abstract]
Schwieters CD, Bermejo GA, Clore GM. Xplor-NIH for molecular structure determination from NMR and other data sources. Protein Sci. 2017 Aug 2; 27 (27; 1; 2017 Aug 2):26-40. [Full Text/Abstract]
Ceccon A, Tugarinov V, Boughton AJ, Fushman D, Clore GM. Probing the Binding Modes of a Multidomain Protein to Lipid-based Nanoparticles by Relaxation-based NMR. J Phys Chem Lett. 2017 May 22; 8 (8; 2017 May 22; 11):2535-2540. [Full Text/Abstract]
Libich DS, Tugarinov V, Ghirlando R, Clore GM. Confinement and Stabilization of Fyn SH3 Folding Intermediate Mimetics within the Cavity of the Chaperonin GroEL Demonstrated by Relaxation-Based NMR. Biochemistry. 2017 Feb 8; 56 (56; 2017 Feb 8; 7):903-906. [Full Text/Abstract]
Schmidt T, Wälti MA, Baber JL, Hustedt EJ, Clore GM. Long Distance Measurements up to 160 Å in the GroEL Tetradecamer Using Q-Band DEER EPR Spectroscopy. Angew Chem Int Ed Engl. 2016 Nov 17; 55 (2016 Nov 17; 55; 51):15905-15909. [Full Text/Abstract]
Deshmukh L, Louis JM, Ghirlando R, Clore GM. Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations. Proc Natl Acad Sci U S A. 2016 Oct 17; 113 (113; 2016 Oct 17; 44):12456-12461. [Full Text/Abstract]
Schmidt T, Ghirlando R, Baber J, Clore GM. Quantitative Resolution of Monomer-Dimer Populations by Inversion Modulated DEER EPR Spectroscopy. Chemphyschem. 2016 Jul 21; 17 (19; 17; 2016 Jul 21):2987-2991. [Full Text/Abstract]
Deshmukh L, Schwieters CD, Grishaev A, Clore GM. Quantitative Characterization of Configurational Space Sampled by HIV-1 Nucleocapsid Using Solution NMR, X-ray Scattering and Protein Engineering. Chemphyschem. 2016 Jun 3; 17 (17; 2016 Jun 3; 11):1548-52. [Full Text/Abstract]
Venditti V, Schwieters CD, Grishaev A, Clore GM. Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering. Proc Natl Acad Sci U S A. 2015 Sep 15; 112 (2015 Sep 15; 37; 112):11565-70. [Full Text/Abstract]
Tugarinov V, Libich DS, Meyer V, Roche J, Clore GM. The energetics of a three-state protein folding system probed by high-pressure relaxation dispersion NMR spectroscopy. Angew Chem Int Ed Engl. 2015 Sep 14; 54 (38; 2015 Sep 14; 54):11157-61. [Full Text/Abstract]
Louis JM, Deshmukh L, Sayer JM, Aniana A, Clore GM. Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease. Biochemistry. 2015 Sep 8; 54 (2015 Sep 8; 35; 54):5414-24. [Full Text/Abstract]
Libich DS, Tugarinov V, Clore GM. Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR. Proc Natl Acad Sci U S A. 2015 Jun 29; 112 (2015 Jun 29; 29; 112):8817-23. [Full Text/Abstract]
Baber JL, Louis JM, Clore GM. Dependence of distance distributions derived from double electron-electron resonance pulsed EPR spectroscopy on pulse-sequence time. Angew Chem Int Ed Engl. 2015 Mar 10; 54 (2015 Mar 10; 54; 18):5336-9. [Full Text/Abstract]
Deshmukh L, Ghirlando R, Clore GM. Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy. Proc Natl Acad Sci U S A. 2015 Feb 23; 112 (2015 Feb 23; 112; 11):3374-9. [Full Text/Abstract]
Anthis NJ, Clore GM. Visualizing transient dark states by NMR spectroscopy. Q Rev Biophys. 2015 Feb; 48 (2015 Feb; 48; 1):35-116. [Full Text/Abstract]
Venditti V, Tugarinov V, Schwieters CD, Grishaev A, Clore GM. Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I. Nat Commun. 2015 Jan 12; 6 (6; 2015 Jan 12):5960. [Full Text/Abstract]
Ryu KS, Tugarinov V, Clore GM. Probing the Rate-Limiting Step for Intramolecular Transfer of a Transcription Factor between Specific Sites on the Same DNA Molecule by 15Nz-Exchange NMR Spectroscopy. J Am Chem Soc. 2014 Sep 25; 136 (2014 Sep 25; 41; 136):14369-14372. [Full Text/Abstract]
Fawzi NL, Libich DS, Ying J, Tugarinov V, Clore GM. Characterizing Methyl-Bearing Side Chain Contacts and Dynamics Mediating Amyloid β Protofibril Interactions Using (13) Cmethyl -DEST and Lifetime Line Broadening. Angew Chem Int Ed Engl. 2014 Aug 11; 53 (39; 53; 2014 Aug 11):10345-10349. [Full Text/Abstract]
Schwieters CD, Clore GM. Using small angle solution scattering data in Xplor-NIH structure calculations. Prog Nucl Magn Reson Spectrosc. 2014 Jul; 80C (80C; 2014 Jul):1-11. [Full Text/Abstract]
Kozakov D, Li K, Hall DR, Beglov D, Zheng J, Vakili P, Schueler-Furman O, Paschalidis ICh, Clore GM, Vajda S. Encounter complexes and dimensionality reduction in protein-protein association. Elife. 2014 Apr 8; 3 (3; 2014 Apr 8):e01370. [Full Text/Abstract]
Clore GM. Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement. Biophys Chem. 2014 Feb; 186 (186; 2014 Feb):3-12. [Full Text/Abstract]
Deshmukh L, Ghirlando R, Clore GM. Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopy. Angew Chem Int Ed Engl. 2014 Jan 20; 53 (4; 53; 2014 Jan 20):1025-8. [Full Text/Abstract]
Clore GM. Seeing the invisible by paramagnetic and diamagnetic NMR. Biochem Soc Trans. 2013 Dec; 41 (6; 2013 Dec; 41):1343-54. [Full Text/Abstract]
Deshmukh L, Schwieters CD, Grishaev A, Ghirlando R, Baber JL, Clore GM. Structure and dynamics of full-length HIV-1 capsid protein in solution. J Am Chem Soc. 2013 Oct 30; 135 (2013 Oct 30; 43; 135):16133-47. [Full Text/Abstract]
Clore GM, Venditti V. Structure, dynamics and biophysics of the cytoplasmic protein-protein complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Trends Biochem Sci. 2013 Oct; 38 (38; 2013 Oct; 10):515-30. [Full Text/Abstract]
Libich DS, Fawzi NL, Ying J, Clore GM. Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR. Proc Natl Acad Sci U S A. 2013 Jul 9; 110 (28; 110; 2013 Jul 9):11361-6. [Full Text/Abstract]
Anthis NJ, Clore GM. The length of the calmodulin linker determines the extent of transient interdomain association and target affinity. J Am Chem Soc. 2013 Jul 3; 135 (2013 Jul 3; 135; 26):9648-51. [Full Text/Abstract]
Venditti V, Ghirlando R, Clore GM. Structural basis for enzyme I inhibition by α-ketoglutarate. ACS Chem Biol. 2013; 8 (6; 8; 2013):1232-40. [Full Text/Abstract]
Grishaev A, Anthis NJ, Clore GM. Contrast-matched small-angle X-ray scattering from a heavy-atom-labeled protein in structure determination: application to a lead-substituted calmodulin-peptide complex. J Am Chem Soc. 2012 Sep 12; 134 (134; 36; 2012 Sep 12):14686-9. [Full Text/Abstract]
Venditti V, Clore GM. Conformational selection and substrate binding regulate the monomer/dimer equilibrium of the C-terminal domain of Escherichia coli enzyme I. J Biol Chem. 2012 Aug 3; 287 (32; 2012 Aug 3; 287):26989-98. [Full Text/Abstract]
Takayama Y, Clore GM. Interplay between minor and major groove-binding transcription factors Sox2 and Oct1 in translocation on DNA studied by paramagnetic and diamagnetic NMR. J Biol Chem. 2012 Apr 27; 287 (287; 2012 Apr 27; 18):14349-63. [Full Text/Abstract]
Anthis NJ, Doucleff M, Clore GM. Transient, sparsely populated compact states of apo and calcium-loaded calmodulin probed by paramagnetic relaxation enhancement: interplay of conformational selection and induced fit. J Am Chem Soc. 2011 Nov 23; 133 (2011 Nov 23; 46; 133):18966-74. [Full Text/Abstract]
Clore GM. Exploring translocation of proteins on DNA by NMR. J Biomol NMR. 2011 Nov; 51 (2011 Nov; 3; 51):209-19. [Full Text/Abstract]
Fawzi NL, Ying J, Ghirlando R, Torchia DA, Clore GM. Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature. 2011 Oct 30; 480 (480; 2011 Oct 30; 7376):268-72. [Full Text/Abstract]
Takayama Y, Clore GM. Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR. Proc Natl Acad Sci U S A. 2011 May 31; 108 (108; 22; 2011 May 31):E169-76. [Full Text/Abstract]
Takayama Y, Schwieters CD, Grishaev A, Ghirlando R, Clore GM. Combined use of residual dipolar couplings and solution X-ray scattering to rapidly probe rigid-body conformational transitions in a non-phosphorylatable active-site mutant of the 128 kDa enzyme I dimer. J Am Chem Soc. 2011 Jan 26; 133 (133; 2011 Jan 26; 3):424-7. [Full Text/Abstract]
Schwieters CD, Suh JY, Grishaev A, Ghirlando R, Takayama Y, Clore GM. Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc. 2010 Sep 22; 132 (2010 Sep 22; 37; 132):13026-45. [Full Text/Abstract]
Fawzi NL, Doucleff M, Suh JY, Clore GM. Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 (107; 2010 Jan 26; 4):1379-84. [Full Text/Abstract]
Clore GM, Iwahara J. Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes. Chem Rev. 2009 Sep; 109 (109; 9; 2009 Sep):4108-39. [Full Text/Abstract]
Doucleff M, Clore GM. Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1. Proc Natl Acad Sci U S A. 2008 Sep 16; 105 (105; 2008 Sep 16; 37):13871-6. [Full Text/Abstract]
Tang C, Schwieters CD, Clore GM. Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature. 2007 Oct 25; 449 (449; 7165; 2007 Oct 25):1078-82. [Full Text/Abstract]
Tang C, Iwahara J, Clore GM. Visualization of transient encounter complexes in protein-protein association. Nature. 2006 Nov 16; 444 (2006 Nov 16; 7117; 444):383-6. [Full Text/Abstract]
Iwahara J, Zweckstetter M, Clore GM. NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A. 2006 Oct 10; 103 (41; 2006 Oct 10; 103):15062-7. [Full Text/Abstract]
Iwahara J, Clore GM. Detecting transient intermediates in macromolecular binding by paramagnetic NMR. Nature. 2006 Apr 27; 440 (7088; 440; 2006 Apr 27):1227-30. [Full Text/Abstract]