U.S. Department of Health and Human Services
Marius Clore

 Contact Info

Tel: 301-496-0782
Email: mariusc@mail.nih.gov

 Select Experience

  • Ph.D.MRC National Institute for Medical Research, London1982
  • M.D.University College Hospital Medical School, London1979
  • B.Sc.University College London1976

 Related Links


G. Marius Clore, M.D., Ph.D., NIH Distinguished Investigator

Section Chief, Protein Nuclear Magnetic Resonance SectionLaboratory of Chemical Physics
  • Biomedical Engineering/Biophysics/Physics
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Venditti V, Schwieters CD, Grishaev A, Clore GM. Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering. Proc Natl Acad Sci U S A. 2015 Sep 15; 112 (2015 Sep 15; 37; 112):11565-70. [Full Text/Abstract]
Tugarinov V, Libich DS, Meyer V, Roche J, Clore GM. The energetics of a three-state protein folding system probed by high-pressure relaxation dispersion NMR spectroscopy. Angew Chem Int Ed Engl. 2015 Sep 14; 54 (38; 2015 Sep 14; 54):11157-61. [Full Text/Abstract]
Louis JM, Deshmukh L, Sayer JM, Aniana A, Clore GM. Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease. Biochemistry. 2015 Sep 8; 54 (2015 Sep 8; 35; 54):5414-24. [Full Text/Abstract]
Libich DS, Tugarinov V, Clore GM. Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR. Proc Natl Acad Sci U S A. 2015 Jun 29; 112 (2015 Jun 29; 29; 112):8817-23. [Full Text/Abstract]
Baber JL, Louis JM, Clore GM. Dependence of distance distributions derived from double electron-electron resonance pulsed EPR spectroscopy on pulse-sequence time. Angew Chem Int Ed Engl. 2015 Mar 10; 54 (2015 Mar 10; 54; 18):5336-9. [Full Text/Abstract]
Deshmukh L, Ghirlando R, Clore GM. Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy. Proc Natl Acad Sci U S A. 2015 Feb 23; 112 (2015 Feb 23; 112; 11):3374-9. [Full Text/Abstract]
Anthis NJ, Clore GM. Visualizing transient dark states by NMR spectroscopy. Q Rev Biophys. 2015 Feb; 48 (2015 Feb; 48; 1):35-116. [Full Text/Abstract]
Venditti V, Tugarinov V, Schwieters CD, Grishaev A, Clore GM. Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I. Nat Commun. 2015 Jan 12; 6 (6; 2015 Jan 12):5960. [Full Text/Abstract]
Ryu KS, Tugarinov V, Clore GM. Probing the Rate-Limiting Step for Intramolecular Transfer of a Transcription Factor between Specific Sites on the Same DNA Molecule by 15Nz-Exchange NMR Spectroscopy. J Am Chem Soc. 2014 Sep 25; 136 (2014 Sep 25; 41; 136):14369-14372. [Full Text/Abstract]
Fawzi NL, Libich DS, Ying J, Tugarinov V, Clore GM. Characterizing Methyl-Bearing Side Chain Contacts and Dynamics Mediating Amyloid β Protofibril Interactions Using (13) Cmethyl -DEST and Lifetime Line Broadening. Angew Chem Int Ed Engl. 2014 Aug 11; 53 (39; 53; 2014 Aug 11):10345-10349. [Full Text/Abstract]
Schwieters CD, Clore GM. Using small angle solution scattering data in Xplor-NIH structure calculations. Prog Nucl Magn Reson Spectrosc. 2014 Jul; 80C (80C; 2014 Jul):1-11. [Full Text/Abstract]
Kozakov D, Li K, Hall DR, Beglov D, Zheng J, Vakili P, Schueler-Furman O, Paschalidis ICh, Clore GM, Vajda S. Encounter complexes and dimensionality reduction in protein-protein association. Elife. 2014 Apr 8; 3 (3; 2014 Apr 8):e01370. [Full Text/Abstract]
Clore GM. Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement. Biophys Chem. 2014 Feb; 186 (186; 2014 Feb):3-12. [Full Text/Abstract]
Deshmukh L, Ghirlando R, Clore GM. Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopy. Angew Chem Int Ed Engl. 2014 Jan 20; 53 (4; 53; 2014 Jan 20):1025-8. [Full Text/Abstract]
Clore GM. Seeing the invisible by paramagnetic and diamagnetic NMR. Biochem Soc Trans. 2013 Dec; 41 (6; 2013 Dec; 41):1343-54. [Full Text/Abstract]
Deshmukh L, Schwieters CD, Grishaev A, Ghirlando R, Baber JL, Clore GM. Structure and dynamics of full-length HIV-1 capsid protein in solution. J Am Chem Soc. 2013 Oct 30; 135 (2013 Oct 30; 43; 135):16133-47. [Full Text/Abstract]
Clore GM, Venditti V. Structure, dynamics and biophysics of the cytoplasmic protein-protein complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Trends Biochem Sci. 2013 Oct; 38 (38; 2013 Oct; 10):515-30. [Full Text/Abstract]
Libich DS, Fawzi NL, Ying J, Clore GM. Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR. Proc Natl Acad Sci U S A. 2013 Jul 9; 110 (28; 110; 2013 Jul 9):11361-6. [Full Text/Abstract]
Anthis NJ, Clore GM. The length of the calmodulin linker determines the extent of transient interdomain association and target affinity. J Am Chem Soc. 2013 Jul 3; 135 (2013 Jul 3; 135; 26):9648-51. [Full Text/Abstract]
Venditti V, Ghirlando R, Clore GM. Structural basis for enzyme I inhibition by α-ketoglutarate. ACS Chem Biol. 2013; 8 (6; 8; 2013):1232-40. [Full Text/Abstract]
Grishaev A, Anthis NJ, Clore GM. Contrast-matched small-angle X-ray scattering from a heavy-atom-labeled protein in structure determination: application to a lead-substituted calmodulin-peptide complex. J Am Chem Soc. 2012 Sep 12; 134 (134; 36; 2012 Sep 12):14686-9. [Full Text/Abstract]
Venditti V, Clore GM. Conformational selection and substrate binding regulate the monomer/dimer equilibrium of the C-terminal domain of Escherichia coli enzyme I. J Biol Chem. 2012 Aug 3; 287 (32; 2012 Aug 3; 287):26989-98. [Full Text/Abstract]
Takayama Y, Clore GM. Interplay between minor and major groove-binding transcription factors Sox2 and Oct1 in translocation on DNA studied by paramagnetic and diamagnetic NMR. J Biol Chem. 2012 Apr 27; 287 (287; 2012 Apr 27; 18):14349-63. [Full Text/Abstract]
Anthis NJ, Doucleff M, Clore GM. Transient, sparsely populated compact states of apo and calcium-loaded calmodulin probed by paramagnetic relaxation enhancement: interplay of conformational selection and induced fit. J Am Chem Soc. 2011 Nov 23; 133 (2011 Nov 23; 46; 133):18966-74. [Full Text/Abstract]
Clore GM. Exploring translocation of proteins on DNA by NMR. J Biomol NMR. 2011 Nov; 51 (2011 Nov; 3; 51):209-19. [Full Text/Abstract]
Fawzi NL, Ying J, Ghirlando R, Torchia DA, Clore GM. Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature. 2011 Oct 30; 480 (480; 2011 Oct 30; 7376):268-72. [Full Text/Abstract]
Takayama Y, Clore GM. Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR. Proc Natl Acad Sci U S A. 2011 May 31; 108 (108; 22; 2011 May 31):E169-76. [Full Text/Abstract]
Takayama Y, Schwieters CD, Grishaev A, Ghirlando R, Clore GM. Combined use of residual dipolar couplings and solution X-ray scattering to rapidly probe rigid-body conformational transitions in a non-phosphorylatable active-site mutant of the 128 kDa enzyme I dimer. J Am Chem Soc. 2011 Jan 26; 133 (133; 2011 Jan 26; 3):424-7. [Full Text/Abstract]
Schwieters CD, Suh JY, Grishaev A, Ghirlando R, Takayama Y, Clore GM. Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc. 2010 Sep 22; 132 (2010 Sep 22; 37; 132):13026-45. [Full Text/Abstract]
Fawzi NL, Doucleff M, Suh JY, Clore GM. Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 (107; 2010 Jan 26; 4):1379-84. [Full Text/Abstract]
Clore GM, Iwahara J. Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes. Chem Rev. 2009 Sep; 109 (109; 9; 2009 Sep):4108-39. [Full Text/Abstract]
Doucleff M, Clore GM. Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1. Proc Natl Acad Sci U S A. 2008 Sep 16; 105 (105; 2008 Sep 16; 37):13871-6. [Full Text/Abstract]
Tang C, Schwieters CD, Clore GM. Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature. 2007 Oct 25; 449 (449; 7165; 2007 Oct 25):1078-82. [Full Text/Abstract]
Tang C, Iwahara J, Clore GM. Visualization of transient encounter complexes in protein-protein association. Nature. 2006 Nov 16; 444 (2006 Nov 16; 7117; 444):383-6. [Full Text/Abstract]
Iwahara J, Zweckstetter M, Clore GM. NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A. 2006 Oct 10; 103 (41; 2006 Oct 10; 103):15062-7. [Full Text/Abstract]
Iwahara J, Clore GM. Detecting transient intermediates in macromolecular binding by paramagnetic NMR. Nature. 2006 Apr 27; 440 (7088; 440; 2006 Apr 27):1227-30. [Full Text/Abstract]