U.S. Department of Health and Human Services
Marius Clore

 Contact Info

Tel: 301-496-0782
Email: mariusc@mail.nih.gov

 Select Experience

  • NIH InvestigatorNIDDK, NIH1988 - present
  • Head, Biological NMR GroupMax Planck Institute for Biochemistry, Martinsried, Germany1984-1988
  • Member of Scientific StaffMRC National Institute for Medical Research, London, U.K.1980-1984
  • House SurgeonSt Charles Hospital (St. Mary's Group)1980
  • House PhysicianUniversity College Hospital1979-1980
  • Ph.D.MRC National Institute for Medical Research, London1982
  • M.D.University College Hospital Medical School, London1979
  • B.Sc. (1st class honors)University College London1976

 Related Links


G. Marius Clore, M.D., Ph.D., NIH Distinguished Investigator

Section Chief, Protein Nuclear Magnetic Resonance SectionLaboratory of Chemical Physics
  • Biomedical Engineering/Biophysics/Physics
  • Structural Biology
Research Summary/In Plain Language

Research Summary

Research Goal

The purpose of my lab’s research is to understand the interrelationship between the structure, dynamics, and function of proteins.    

Current Research

Our lab studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and we develop and apply novel NMR and computational methods to aid in these studies.  We are particularly interested in complexes involved in signal transduction and transcriptional regulation, and on AIDS and AIDS-related proteins.  More recently we have focused on the development of novel NMR methods to detect, visualize, and characterize transient, sparsely populated states of macromolecules.  Such states, which are invisible to conventional biophysical techniques, including crystallography, play a critical role in macromolecular recognition, allostery induced fit, conformational selection, and molecular assembly.​ Dr. Clore is an elected member of the National Academy of Sciences, the American Academy of Arts and Sciences and Academia Europaea.

Applying our Research

This research will facilitate targeted and rational drug design.