U.S. Department of Health and Human Services
Gary Felsenfeld

 Contact Info

Tel: 301-496-4173
Email: garyf@intra.niddk.nih.gov

 Select Experience

  • Ph.D.California Institute of Technology1955
  • B.A.Harvard University1951

 Related Links


Gary Felsenfeld, Ph.D., NIH Distinguished Investigator

Section Chief, Physical Chemistry SectionLaboratory of Molecular Biology
  • Chemistry/Chemical Biology
  • Chromosome Biology/Epigenetics


A selection of recent and significant publications can be viewed below.

Atwood BL, Woolnough JL, Lefevre GM, Saint Just Ribeiro M, Felsenfeld G, Giles KE. Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions. J Biol Chem. 2016 Jun 10; 291 (291; 2016 Jun 10; 34):17919-28. [Full Text/Abstract]
Ghirlando R, Felsenfeld G. CTCF: making the right connections. Genes Dev. 2016 Apr 15; 30 (2016 Apr 15; 30; 8):881-91. [Full Text/Abstract]
Wongtrakoongate P, Riddick G, Fucharoen S, Felsenfeld G. Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes. PLoS Genet. 2015 Oct; 11 (2015 Oct; 10; 11):e1005615. [Full Text/Abstract]
Xiao T, Wongtrakoongate P, Trainor C, Felsenfeld G. CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites. Cell Rep. 2015 Sep 8; 12 (2015 Sep 8; 12; 10):1704-14. [Full Text/Abstract]
Xu Z, Lefevre GM, Gavrilova O, Foster St Claire MB, Riddick G, Felsenfeld G. Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion. Proc Natl Acad Sci U S A. 2014 Nov 10; 111 (2014 Nov 10; 111; 47):16760-5. [Full Text/Abstract]
Felsenfeld G. The evolution of epigenetics. Perspect Biol Med. 2014 Winter; 57 (1; 2014 Winter; 57):132-48. [Full Text/Abstract]
Felsenfeld G. A brief history of epigenetics. Cold Spring Harb Perspect Biol. 2014 Jan 1; 6 (6; 2014 Jan 1; 1). [Full Text/Abstract]
Ghirlando R, Felsenfeld G. Physical chemistry of nucleic acids and their complexes. Biopolymers. 2013 Dec; 99 (2013 Dec; 12; 99):910-5. [Full Text/Abstract]
Ghirlando R, Felsenfeld G. Chromatin structure outside and inside the nucleus. Biopolymers. 2013 Apr; 99 (4; 99; 2013 Apr):225-32. [Full Text/Abstract]
Xu Z, Felsenfeld G. Order from chaos in the nucleus. Mol Cell. 2012 Nov 9; 48 (48; 2012 Nov 9; 3):327-8. [Full Text/Abstract]
Xu Z, Lefevre GM, Felsenfeld G. Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus. Diabetes Obes Metab. 2012 Oct; 14 Suppl 3 (2012 Oct; 14 Suppl 3):1-11. [Full Text/Abstract]
Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G. Chromatin domains, insulators, and the regulation of gene expression. Biochim Biophys Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819):644-51. [Full Text/Abstract]
Felsenfeld G, Dekker J. Genome architecture and expression. Curr Opin Genet Dev. 2012 Apr; 22 (2; 2012 Apr; 22):59-61. [Full Text/Abstract]
Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G. Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Feb 14; 109 (109; 7; 2012 Feb 14):2370-5. [Full Text/Abstract]
Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S. Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Blood. 2011 Aug 4; 118 (118; 2011 Aug 4; 5):1386-94. [Full Text/Abstract]
Xiao T, Wallace J, Felsenfeld G. Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol. 2011 Jun; 31 (2011 Jun; 11; 31):2174-83. [Full Text/Abstract]
Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G. Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. Nat Struct Mol Biol. 2011 Mar; 18 (2011 Mar; 3; 18):372-8. [Full Text/Abstract]
Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G. Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev. 2010 Nov 15; 24 (2010 Nov 15; 24; 22):2543-55. [Full Text/Abstract]
Dickson J, Gowher H, Strogantsev R, Gaszner M, Hair A, Felsenfeld G, West AG. VEZF1 elements mediate protection from DNA methylation. PLoS Genet. 2010 Jan; 6 (6; 2010 Jan; 1):e1000804. [Full Text/Abstract]
Giles KE, Ghirlando R, Felsenfeld G. Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism. Nat Cell Biol. 2010 Jan; 12 (2010 Jan; 12; 1):94-9; sup pp 1-6. [Full Text/Abstract]
Giles KE, Gowher H, Ghirlando R, Jin C, Felsenfeld G. Chromatin boundaries, insulators, and long-range interactions in the nucleus. Cold Spring Harb Symp Quant Biol. 2010; 75 (2010; 75):79-85. [Full Text/Abstract]
Mutskov V, Felsenfeld G. The human insulin gene is part of a large open chromatin domain specific for human islets. Proc Natl Acad Sci U S A. 2009 Oct 13; 106 (106; 2009 Oct 13; 41):17419-24. [Full Text/Abstract]
Jin C, Zang C, Wei G, Cui K, Peng W, Zhao K, Felsenfeld G. H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet. 2009 Aug; 41 (2009 Aug; 8; 41):941-5. [Full Text/Abstract]
Gowher H, Stuhlmann H, Felsenfeld G. Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b. Genes Dev. 2008 Aug 1; 22 (2008 Aug 1; 15; 22):2075-84. [Full Text/Abstract]
Ghirlando R, Felsenfeld G. Hydrodynamic studies on defined heterochromatin fragments support a 30-nm fiber having six nucleosomes per turn. J Mol Biol. 2008 Mar 7; 376 (376; 2008 Mar 7; 5):1417-25. [Full Text/Abstract]
Jin C, Felsenfeld G. Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev. 2007 Jun 15; 21 (12; 21; 2007 Jun 15):1519-29. [Full Text/Abstract]
Jin C, Felsenfeld G. Distribution of histone H3.3 in hematopoietic cell lineages. Proc Natl Acad Sci U S A. 2006 Jan 17; 103 (2006 Jan 17; 3; 103):574-9. [Full Text/Abstract]
Huang S, Litt M, Felsenfeld G. Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev. 2005 Aug 15; 19 (19; 16; 2005 Aug 15):1885-93. [Full Text/Abstract]
West AG, Huang S, Gaszner M, Litt MD, Felsenfeld G. Recruitment of histone modifications by USF proteins at a vertebrate barrier element. Mol Cell. 2004 Nov 5; 16 (2004 Nov 5; 16; 3):453-63. [Full Text/Abstract]
Studitsky VM, Walter W, Kireeva M, Kashlev M, Felsenfeld G. Chromatin remodeling by RNA polymerases. Trends Biochem Sci. 2004 Mar; 29 (2004 Mar; 3; 29):127-35. [Full Text/Abstract]
Ghirlando R, Litt MD, Prioleau MN, Recillas-Targa F, Felsenfeld G. Physical properties of a genomic condensed chromatin fragment. J Mol Biol. 2004 Feb 20; 336 (2004 Feb 20; 3; 336):597-605. [Full Text/Abstract]
Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell. 2004 Jan 30; 13 (2; 13; 2004 Jan 30):291-8. [Full Text/Abstract]
Mutskov V, Felsenfeld G. Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J. 2004 Jan 14; 23 (2004 Jan 14; 23; 1):138-49. [Full Text/Abstract]
Felsenfeld G, Groudine M. Controlling the double helix. Nature. 2003 Jan 23; 421 (421; 2003 Jan 23; 6921):448-53. [Full Text/Abstract]
West AG, Gaszner M, Felsenfeld G. Insulators: many functions, many mechanisms. Genes Dev. 2002 Feb 1; 16 (2002 Feb 1; 16; 3):271-88. [Full Text/Abstract]