U.S. Department of Health and Human Services
Gregory Germino

 Contact Info

Tel: 301-496-5877
Email: germinogg@mail.nih.gov

 Select Experience

  • Senior InvestigatorKidney Diseases Branch, NIDDK, NIH2009–Present
  • Adjunct Professor of MedicineJohns Hopkins University School of Medicine2009–Present
  • Professor of Medicine Division of Nephrology, Johns Hopkins University School of Medicine2003–2009
  • Affiliate MemberMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine2002–2009
  • Joint AppointmentDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine2001–2009
  • Associate Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1997–2003
  • Assistant Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1992–1997
  • Associate Research ScientistInstructor and Assistant Professor, Yale University School of Medicine1988–1992
  • Research Post-Doctoral FellowNuffield Department of Medicine, Oxford University1987–1988
  • Clinical Post-Doctoral FellowNephrology, Yale University School of Medicine1986–1987
  • Internal Medicine ResidencyYale–New Haven Hospital1983–1986
  • M.D.University of Chicago Pritzker School of Medicine1983
  • B.S.Loyola University of Chicago1979

 Related Links


Gregory G. Germino, M.D.

Deputy Director, Office of the Director​
Section Chief, Polycystic Kidney Disease Laboratory, Kidney Diseases Branch

Specialties: Molecular Biology/Biochemistry, Genetics/Genomics, Nephrology

Gregory G. Germino, M.D.

Section Chief, Polycystic Kidney Disease LaboratoryKidney Diseases Branch
Deputy Director, Office of the Director
Deputy Director, Office of the Deputy Director
  • Cell Biology/Cell Signaling
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Nephrology
  • Systems Biology
Research Summary/In Plain Language

Research in Plain Language

My research is focused on the causes of cysts inside the kidney. This is known as renal cystic disease. Kidney function depends on the tubes inside the kidney having proper structure. If the cysts block the tubes or if the tubes are not well formed, the kidney can underperform or fail. However, scientists do not clearly understand the factors that control the diameter of tubes within the kidney or the creation of cysts. There are hereditary, developmental, and acquired conditions that affect the growth of cysts or the formation of the tubes inside the kidney. Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder and an important cause of kidney failure. Autosomal recessive polycystic kidney disease (ARPKD) is less common but more severe. My group has helped identify PKD1 and PKHD1, the primary genes involved in ADPKD and ARPKD, and we have developed methods that can detect mutations that alter their sequence. A major focus of our group is to determine how these genes function to regulate the size of tubes and how defects in their function cause cysts to form. Our long-term goal is to use this information to guide development of therapies that prevent and treat cystic disease.