U.S. Department of Health and Human Services
Gregory Germino

 Contact Info

Tel: 301-496-5877
Email: germinogg@mail.nih.gov

 Select Experience

  • Senior InvestigatorKidney Diseases Branch, NIDDK, NIH2009–Present
  • Adjunct Professor of MedicineJohns Hopkins University School of Medicine2009–Present
  • Professor of Medicine Division of Nephrology, Johns Hopkins University School of Medicine2003–2009
  • Affiliate MemberMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine2002–2009
  • Joint AppointmentDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine2001–2009
  • Associate Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1997–2003
  • Assistant Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1992–1997
  • Associate Research ScientistInstructor and Assistant Professor, Yale University School of Medicine1988–1992
  • Research Post-Doctoral FellowNuffield Department of Medicine, Oxford University1987–1988
  • Clinical Post-Doctoral FellowNephrology, Yale University School of Medicine1986–1987
  • Internal Medicine ResidencyYale–New Haven Hospital1983–1986
  • M.D.University of Chicago Pritzker School of Medicine1983
  • B.S.Loyola University of Chicago1979

 Related Links


Gregory G. Germino, M.D.

Deputy Director, Office of the Director​
Section Chief, Polycystic Kidney Disease Laboratory, Kidney Diseases Branch

Specialties: Molecular Biology/Biochemistry, Genetics/Genomics, Nephrology

Gregory G. Germino, M.D.

Section Chief, Polycystic Kidney Disease LaboratoryKidney Diseases Branch
Deputy Director, Office of the Director
Deputy Director, Office of the Deputy Director
  • Cell Biology/Cell Signaling
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Nephrology
  • Systems Biology


A selection of recent and significant publications can be viewed below.

Outeda P, Menezes L, Hartung EA, Bridges S, Zhou F, Zhu X, Xu H, Huang Q, Yao Q, Qian F, Germino GG, Watnick T. A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism. Kidney Int. 2017 Jul 17; (2017 Jul 17). [Full Text/Abstract]
Menezes LF, Lin CC, Zhou F, Germino GG. Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease. EBioMedicine. 2016 Mar; 5 (2016 Mar; 5):183-92. [Full Text/Abstract]
Menezes LF, Germino GG. Systems biology of polycystic kidney disease: a critical review. Wiley Interdiscip Rev Syst Biol Med. 2015 Feb 2; 7 (7; 2015 Feb 2; 1):39-52. [Full Text/Abstract]
Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, Cebotaru V, Chiaravalli M, Boletta A, Piontek K, Germino GG, Weinman EJ, Watnick T, Qian F. Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun. 2014 Nov 18; 5 (2014 Nov 18; 5):5482. [Full Text/Abstract]
Lee YL, Santé J, Comerci CJ, Cyge B, Menezes LF, Li FQ, Germino GG, Moerner WE, Takemaru K, Stearns T. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. Mol Biol Cell. 2014 Aug 7; 25 (25; 19; 2014 Aug 7):2919-33. [Full Text/Abstract]
Boddu R, Yang C, O'Connor AK, Hendrickson RC, Boone B, Cui X, Garcia-Gonzalez M, Igarashi P, Onuchic LF, Germino GG, Guay-Woodford LM. Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1. J Mol Med (Berl). 2014 Jul 3; 92 (92; 10; 2014 Jul 3):1045-56. [Full Text/Abstract]
Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, Germino GG, Watnick T. Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development. Cell Rep. 2014 May 8; 7 (7; 3; 2014 May 8):634-44. [Full Text/Abstract]
Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T. A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2014 Jan; 25 (25; 2014 Jan; 1):81-91. [Full Text/Abstract]
Watnick TJ, Germino GG. Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated. Nat Rev Nephrol. 2013 May; 9 (2013 May; 9; 5):249-50. [Full Text/Abstract]
Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T. A missense mutation in PKD1 attenuates the severity of renal disease. Kidney Int. 2012 Feb; 81 (81; 2012 Feb; 4):412-7. [Full Text/Abstract]
Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier. PLoS Genet. 2012; 8 (2012; 8; 11):e1003053. [Full Text/Abstract]
Miller MM, Iglesias DM, Zhang Z, Corsini R, Chu L, Murawski I, Gupta I, Somlo S, Germino GG, Goodyer PR. T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease. Kidney Int. 2011 Jul; 80 (2; 2011 Jul; 80):146-53. [Full Text/Abstract]
Ferreira FM, Oliveira LC, Germino GG, Onuchic JN, Onuchic LF. Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain. Proc Natl Acad Sci U S A. 2011 Jun 14; 108 (108; 2011 Jun 14; 24):9833-8. [Full Text/Abstract]
Watnick T, Germino GG. mTOR inhibitors in polycystic kidney disease. N Engl J Med. 2010 Aug 26; 363 (2010 Aug 26; 363; 9):879-81. [Full Text/Abstract]
Shillingford JM, Piontek KB, Germino GG, Weimbs T. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J Am Soc Nephrol. 2010 Mar; 21 (21; 3; 2010 Mar):489-97. [Full Text/Abstract]
Menezes LF, Germino GG. Polycystic kidney disease, cilia, and planar polarity. Methods Cell Biol. 2009; 94 (94; 2009):273-97. [Full Text/Abstract]
Raphael KL, Strait KA, Stricklett PK, Baird BC, Piontek K, Germino GG, Kohan DE. Effect of pioglitazone on survival and renal function in a mouse model of polycystic kidney disease. Am J Nephrol. 2009; 30 (30; 2009; 5):468-73. [Full Text/Abstract]
Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med. 2007 Dec; 13 (2007 Dec; 12; 13):1490-5. [Full Text/Abstract]
Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007 Aug 15; 16 (2007 Aug 15; 16):1940-50. [Full Text/Abstract]
Kaimori JY, Nagasawa Y, Menezes LF, Garcia-Gonzalez MA, Deng J, Imai E, Onuchic LF, Guay-Woodford LM, Germino GG. Polyductin undergoes notch-like processing and regulated release from primary cilia. Hum Mol Genet. 2007 Apr 15; 16 (8; 16; 2007 Apr 15):942-56. [Full Text/Abstract]
Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 2006 Apr 4; 103 (2006 Apr 4; 14; 103):5466-71. [Full Text/Abstract]
Germino GG. Linking cilia to Wnts. Nat Genet. 2005 May; 37 (2005 May; 37; 5):455-7. [Full Text/Abstract]
Onuchic LF, Furu L, Nagasawa Y, Hou X, Eggermann T, Ren Z, Bergmann C, Senderek J, Esquivel E, Zeltner R, Rudnik-Schöneborn S, Mrug M, Sweeney W, Avner ED, Zerres K, Guay-Woodford LM, Somlo S, Germino GG. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet. 2002 May; 70 (2002 May; 70; 5):1305-17. [Full Text/Abstract]
Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell. 2002 Apr 19; 109 (109; 2002 Apr 19; 2):157-68. [Full Text/Abstract]
Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000 Dec 21-28; 408 (2000 Dec 21-28; 408; 6815):990-4. [Full Text/Abstract]
Boletta A, Qian F, Onuchic LF, Bhunia AK, Phakdeekitcharoen B, Hanaoka K, Guggino W, Monaco L, Germino GG. Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells. Mol Cell. 2000 Nov; 6 (2000 Nov; 6; 5):1267-73. [Full Text/Abstract]
Watnick T, He N, Wang K, Liang Y, Parfrey P, Hefferton D, St George-Hyslop P, Germino G, Pei Y. Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations. Nat Genet. 2000 Jun; 25 (25; 2000 Jun; 2):143-4. [Full Text/Abstract]
Watnick TJ, Torres VE, Gandolph MA, Qian F, Onuchic LF, Klinger KW, Landes G, Germino GG. Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease. Mol Cell. 1998 Aug; 2 (2; 1998 Aug):247-51. [Full Text/Abstract]
Qian F, Germino FJ, Cai Y, Zhang X, Somlo S, Germino GG. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat Genet. 1997 Jun; 16 (1997 Jun; 16; 2):179-83. [Full Text/Abstract]
Qian F, Watnick TJ, Onuchic LF, Germino GG. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell. 1996 Dec 13; 87 (1996 Dec 13; 6; 87):979-87. [Full Text/Abstract]