U.S. Department of Health and Human Services
Harold Smith

 Contact Info

Tel: 301-594-6554
Email: harold.smith@nih.gov

 Select Experience

  • Ph.D.Columbia University1995
  • M.Phil.Columbia University1994
  • M.A.Columbia University1990

 Related Links


Harold Smith, Ph.D.

Head, Genomics Core
  • Cell Biology/Cell Signaling
  • Chromosome Biology/Epigenetics
  • Computational Biology/Bioinformatics/Biostatistics/Mathematics
  • Developmental Biology
  • Genetics/Genomics
  • Systems Biology


A selection of recent and significant publications can be viewed below.

Fukushige T, Smith HE, Miwa J, Krause MW, Hanover JA. A Genetic Analysis of the Caenorhabditis elegans Detoxification Response. Genetics. 2017 Apr 19; 206 (206; 2017 Apr 19; 2):939-952. [Full Text/Abstract]
Davison JR, Lohith KM, Wang X, Bobyk K, Mandadapu SR, Lee SL, Cencic R, Nelson J, Simpkins S, Frank KM, Pelletier J, Myers CL, Piotrowski J, Smith HE, Bewley CA. A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter. Antimicrob Agents Chemother. 2017 Apr 3; 61 (6; 2017 Apr 3; 61). [Full Text/Abstract]
Smith HE, Yun S. Evaluating alignment and variant-calling software for mutation identification in C. elegans by whole-genome sequencing. PLoS One. 2017; 12 (2017; 12; 3):e0174446. [Full Text/Abstract]
Lee HK, Willi M, Wang C, Yang CM, Smith HE, Liu C, Hennighausen L. Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice. Nucleic Acids Res. 2017 Mar 16; 45 (8; 2017 Mar 16; 45):4606-4618. [Full Text/Abstract]
Jaramillo-Lambert A, Fabritius AS, Hansen TJ, Smith HE, Golden A. The Identification of a Novel Mutant Allele of topoisomerase II in Caenorhabditis elegans Reveals a Unique Role in Chromosome Segregation During Spermatogenesis. Genetics. 2016 Oct 5; 204 (2016 Oct 5; 204; 4):1407-1422. [Full Text/Abstract]
Smith HE, Fabritius AS, Jaramillo-Lambert A, Golden A. Mapping Challenging Mutations by Whole-Genome Sequencing. G3 (Bethesda). 2016 Mar 4; 6 (2016 Mar 4; 6; 5):1297-304. [Full Text/Abstract]
Thompson KW, Joshi P, Dymond JS, Gorrepati L, Smith HE, Krause MW, Eisenmann DM. The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans. Dev Biol. 2016 Mar 4; 412 (2016 Mar 4; 412; 2):191-207. [Full Text/Abstract]
Miller JG, Liu Y, Williams CW, Smith HE, O'Connell KF. The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans. G3 (Bethesda). 2016 Jan 15; 6 (6; 2016 Jan 15; 3):709-20. [Full Text/Abstract]
Singaravelu G, Rahimi S, Krauchunas A, Rizvi A, Dharia S, Shakes D, Smith H, Golden A, Singson A. Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization. Curr Biol. 2015 Dec 6; 25 (25; 2015 Dec 6; 24):3220-4. [Full Text/Abstract]
Liu Z, Shi H, Szymczak LC, Aydin T, Yun S, Constas K, Schaeffer A, Ranjan S, Kubba S, Alam E, McMahon DE, He J, Shwartz N, Tian C, Plavskin Y, Lindy A, Dad NA, Sheth S, Amin NM, Zimmerman S, Liu D, Schwarz EM, Smith H, Krause MW, Liu J. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genet. 2015 May; 11 (2015 May; 5; 11):e1005221. [Full Text/Abstract]
Jaramillo-Lambert A, Fuchsman AS, Fabritius AS, Smith HE, Golden A. Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing. G3 (Bethesda). 2015 Mar 4; 5 (5; 2015 Mar 4):1007-19. [Full Text/Abstract]
Smith HE. Library Construction for Mutation Identification by Whole-Genome Sequencing. Methods Mol Biol. 2015; 1327 (2015; 1327):1-9. [Full Text/Abstract]
Clough E, Jimenez E, Kim YA, Whitworth C, Neville MC, Hempel LU, Pavlou HJ, Chen ZX, Sturgill D, Dale RK, Smith HE, Przytycka TM, Goodwin SF, Van Doren M, Oliver B. Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes. Dev Cell. 2014 Dec 22; 31 (2014 Dec 22; 6; 31):761-73. [Full Text/Abstract]
Paix A, Wang Y, Smith HE, Lee CY, Calidas D, Lu T, Smith J, Schmidt H, Krause MW, Seydoux G. Scalable and Versatile Genome Editing Using Linear DNAs with Micro-Homology to Cas9 Sites in Caenorhabditis elegans. Genetics. 2014 Sep 23; 198 (2014 Sep 23; 4; 198):1347-56. [Full Text/Abstract]
Chen ZX, Sturgill D, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B, Richards S. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Genome Res. 2014 Jul; 24 (7; 2014 Jul; 24):1209-23. [Full Text/Abstract]
Smith HE. Nematode sperm motility. WormBook. 2014 Apr 4; (2014 Apr 4):1-15. [Full Text/Abstract]
Wang Y, Wang JT, Rasoloson D, Stitzel ML, O' Connell KF, Smith HE, Seydoux G. Identification of suppressors of mbk-2/DYRK by whole-genome sequencing. G3 (Bethesda). 2014 Feb 19; 4 (2014 Feb 19; 2; 4):231-41. [Full Text/Abstract]