U.S. Department of Health and Human Services
Harris Bernstein

 Contact Info

Tel: 301-402-4770
Email: harris_bernstein@nih.gov

 Select Experience

  • Ph.D.Massachusetts Institute of Technology1987
  • B.A.Harvard University1980

 Related Links


Harris D. Bernstein, Ph.D.

Section Chief, Protein Biogenesis SectionGenetics and Biochemistry Branch
  • Microbiology/Infectious diseases (non-viral)
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Hussain S, Bernstein HD. The Bam complex catalyzes efficient insertion of bacterial outer membrane proteins into membrane vesicles of variable lipid composition. J Biol Chem. 2018 Jan 8; 293 (8; 293; 2018 Jan 8):2959-2973. [Full Text/Abstract]
Sikdar R, Peterson JH, Anderson DE, Bernstein HD. Folding of a bacterial integral outer membrane protein is initiated in the periplasm. Nat Commun. 2017 Nov 3; 8 (2017 Nov 3; 8; 1):1309. [Full Text/Abstract]
Bernstein HD. Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway. Mol Microbiol. 2015 Apr 17; 97 (2015 Apr 17; 2; 97):205-15. [Full Text/Abstract]
Wilson MM, Anderson DE, Bernstein HD. Analysis of the outer membrane proteome and secretome of Bacteroides fragilis reveals a multiplicity of secretion mechanisms. PLoS One. 2015 Feb 6; 10 (2; 10; 2015 Feb 6):e0117732. [Full Text/Abstract]
Roman-Hernandez G, Peterson JH, Bernstein HD. Reconstitution of bacterial autotransporter assembly using purified components. Elife. 2014 Sep 2; 3 (2014 Sep 2; 3). [Full Text/Abstract]
Kang'ethe W, Bernstein HD. Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway. Proc Natl Acad Sci U S A. 2013 Nov 5; 110 (110; 2013 Nov 5; 45):E4246-55. [Full Text/Abstract]
Pavlova O, Peterson JH, Ieva R, Bernstein HD. Mechanistic link between β barrel assembly and the initiation of autotransporter secretion. Proc Natl Acad Sci U S A. 2013 Mar 5; 110 (110; 10; 2013 Mar 5):E938-47. [Full Text/Abstract]
Bernstein HD. Cell biology: All clear for ribosome landing. Nature. 2012 Dec 13; 492 (492; 2012 Dec 13; 7428):189-91. [Full Text/Abstract]
Ieva R, Tian P, Peterson JH, Bernstein HD. Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain. Proc Natl Acad Sci U S A. 2011 Aug 2; 108 (108; 2011 Aug 2; 31):E383-91. [Full Text/Abstract]
Peterson JH, Tian P, Ieva R, Dautin N, Bernstein HD. Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment. Proc Natl Acad Sci U S A. 2010 Oct 12; 107 (107; 2010 Oct 12; 41):17739-44. [Full Text/Abstract]
Ieva R, Bernstein HD. Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane. Proc Natl Acad Sci U S A. 2009 Nov 10; 106 (106; 2009 Nov 10; 45):19120-5. [Full Text/Abstract]
Yap MN, Bernstein HD. The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel. Mol Cell. 2009 Apr 24; 34 (2; 2009 Apr 24; 34):201-11. [Full Text/Abstract]