U.S. Department of Health and Human Services
Herman Edskes

 Contact Info

Tel: 301-496-1309
Email: edskes@helix.nih.gov

 Select Experience

  • Research FellowNIH2000-2001
  • Postdoctoral FellowNIH1995-1999
  • Ph.D.University of Kentucky1994
  • M.Sc.Wageningen University1990

 Related Links

  • Genetics/Genomics
  • Microbiology/Infectious diseases (non-viral)
  • Molecular Biology/Biochemistry
  • Prions
  • Virology


A selection of recent and significant publications can be viewed below.

Engel A, Shewmaker F, Edskes HK, Dyda F, Wickner RB. Amyloid of the Candida albicans Ure2p prion domain is infectious and has an in-register parallel β-sheet structure. Biochemistry. 2011 Jul 12; 50 (2011 Jul 12; 50; 27):5971-8. [Full Text/Abstract]
Edskes HK, Engel A, McCann LM, Brachmann A, Tsai HF, Wickner RB. Prion-forming ability of Ure2 of yeasts is not evolutionarily conserved. Genetics. 2011 May; 188 (188; 1; 2011 May):81-90. [Full Text/Abstract]
Hall D, Edskes H. A model of amyloid's role in disease based on fibril fracture. Biophys Chem. 2009 Nov; 145 (145; 2009 Nov; 1):17-28. [Full Text/Abstract]
Edskes HK, McCann LM, Hebert AM, Wickner RB. Prion variants and species barriers among Saccharomyces Ure2 proteins. Genetics. 2009 Mar; 181 (181; 3; 2009 Mar):1159-67. [Full Text/Abstract]
Edskes HK, Naglieri BM, Wickner RB. Nitrogen source and the retrograde signalling pathway affect detection, not generation, of the [URE3] prion. Yeast. 2006 Aug; 23 (2006 Aug; 23; 11):833-40. [Full Text/Abstract]
Ross ED, Edskes HK, Terry MJ, Wickner RB. Primary sequence independence for prion formation. Proc Natl Acad Sci U S A. 2005 Sep 6; 102 (102; 36; 2005 Sep 6):12825-30. [Full Text/Abstract]
Nakayashiki T, Kurtzman CP, Edskes HK, Wickner RB. Yeast prions [URE3] and [PSI+] are diseases. Proc Natl Acad Sci U S A. 2005 Jul 26; 102 (30; 102; 2005 Jul 26):10575-80. [Full Text/Abstract]
Hall D, Edskes H. Silent prions lying in wait: a two-hit model of prion/amyloid formation and infection. J Mol Biol. 2004 Feb 20; 336 (2004 Feb 20; 3; 336):775-86. [Full Text/Abstract]
Edskes HK, Wickner RB. Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein. Proc Natl Acad Sci U S A. 2002 Dec 10; 99 Suppl 4 (99 Suppl 4; 2002 Dec 10):16384-91. [Full Text/Abstract]
Bradley ME, Edskes HK, Hong JY, Wickner RB, Liebman SW. Interactions among prions and prion "strains" in yeast. Proc Natl Acad Sci U S A. 2002 Dec 10; 99 Suppl 4 (99 Suppl 4; 2002 Dec 10):16392-9. [Full Text/Abstract]