U.S. Department of Health and Human Services
Hoi Sung Chung
 

 Contact Info

 
Tel: 301-496-0202
Email: chunghoi@niddk.nih.gov
 

 Select Experience

 
  • Ph.D.Massachusetts Institute of Technology2007
  • M.S.Seoul National University2000
  • B.S.Seoul National University1998
 

 Related Links

 

Hoi Sung Chung, Ph.D.

Investigator, Biophysical Chemistry SectionLaboratory of Chemical Physics
Specialties
  • Biomedical Engineering/Biophysics/Physics
  • Structural Biology

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Chung HS, Gopich IV. Fast single-molecule FRET spectroscopy: theory and experiment. Phys Chem Chem Phys. 2014 Sep 21; 16 (35; 2014 Sep 21; 16):18644-57. [Full Text/Abstract]
Chung HS, Eaton WA. Single-molecule fluorescence probes dynamics of barrier crossing. Nature. 2013 Oct 31; 502 (7473; 2013 Oct 31; 502):685-8. [Full Text/Abstract]
Chung HS, Cellmer T, Louis JM, Eaton WA. Measuring ultrafast protein folding rates from photon-by-photon analysis of single molecule fluorescence trajectories. Chem Phys. 2013 Aug 30; 422 (422; 2013 Aug 30):229-237. [Full Text/Abstract]
Boura E, Różycki B, Chung HS, Herrick DZ, Canagarajah B, Cafiso DS, Eaton WA, Hummer G, Hurley JH. Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure. 2012 May 9; 20 (20; 2012 May 9; 5):874-86. [Full Text/Abstract]
Chung HS, McHale K, Louis JM, Eaton WA. Single-molecule fluorescence experiments determine protein folding transition path times. Science. 2012 Feb 24; 335 (335; 6071; 2012 Feb 24):981-4. [Full Text/Abstract]
Boura E, Rózycki B, Herrick DZ, Chung HS, Vecer J, Eaton WA, Cafiso DS, Hummer G, Hurley JH. Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A. 2011 Jun 7; 108 (108; 23; 2011 Jun 7):9437-42. [Full Text/Abstract]
Chung HS, Gopich IV, McHale K, Cellmer T, Louis JM, Eaton WA. Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein. J Phys Chem A. 2011 Apr 28; 115 (16; 2011 Apr 28; 115):3642-56. [Full Text/Abstract]
Chung HS, Louis JM, Eaton WA. Distinguishing between protein dynamics and dye photophysics in single-molecule FRET experiments. Biophys J. 2010 Feb 17; 98 (98; 2010 Feb 17; 4):696-706. [Full Text/Abstract]
Chung HS, Louis JM, Eaton WA. Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories. Proc Natl Acad Sci U S A. 2009 Jul 21; 106 (106; 2009 Jul 21; 29):11837-44. [Full Text/Abstract]
Chung HS, Shandiz A, Sosnick TR, Tokmakoff A. Probing the folding transition state of ubiquitin mutants by temperature-jump-induced downhill unfolding. Biochemistry. 2008 Dec 30; 47 (2008 Dec 30; 52; 47):13870-7. [Full Text/Abstract]
Chung HS, Tokmakoff A. Temperature-dependent downhill unfolding of ubiquitin. I. Nanosecond-to-millisecond resolved nonlinear infrared spectroscopy. Proteins. 2008 Jul; 72 (72; 2008 Jul; 1):474-87. [Full Text/Abstract]
Chung HS, Tokmakoff A. Temperature-dependent downhill unfolding of ubiquitin. II. Modeling the free energy surface. Proteins. 2008 Jul; 72 (72; 2008 Jul; 1):488-97. [Full Text/Abstract]
Ganim Z, Chung HS, Smith AW, Deflores LP, Jones KC, Tokmakoff A. Amide I two-dimensional infrared spectroscopy of proteins. Acc Chem Res. 2008 Mar; 41 (2008 Mar; 41; 3):432-41. [Full Text/Abstract]
Chung HS, Ganim Z, Jones KC, Tokmakoff A. Transient 2D IR spectroscopy of ubiquitin unfolding dynamics. Proc Natl Acad Sci U S A. 2007 Sep 4; 104 (104; 36; 2007 Sep 4):14237-42. [Full Text/Abstract]
Chung HS, Khalil M, Smith AW, Tokmakoff A. Transient two-dimensional IR spectrometer for probing nanosecond temperature-jump kinetics. Rev Sci Instrum. 2007 Jun; 78 (6; 2007 Jun; 78):063101. [Full Text/Abstract]
DeFlores LP, Ganim Z, Ackley SF, Chung HS, Tokmakoff A. The anharmonic vibrational potential and relaxation pathways of the amide I and II modes of N-methylacetamide. J Phys Chem B. 2006 Sep 28; 110 (38; 110; 2006 Sep 28):18973-80. [Full Text/Abstract]
Chung HS, Tokmakoff A. Visualization and characterization of the infrared active amide I vibrations of proteins. J Phys Chem B. 2006 Feb 16; 110 (6; 110; 2006 Feb 16):2888-98. [Full Text/Abstract]
Smith AW, Chung HS, Ganim Z, Tokmakoff A. Residual native structure in a thermally denatured beta-hairpin. J Phys Chem B. 2005 Sep 15; 109 (109; 2005 Sep 15; 36):17025-7. [Full Text/Abstract]
Chung HS, Khalil M, Smith AW, Ganim Z, Tokmakoff A. Conformational changes during the nanosecond-to-millisecond unfolding of ubiquitin. Proc Natl Acad Sci U S A. 2005 Jan 18; 102 (102; 2005 Jan 18; 3):612-7. [Full Text/Abstract]
Demirdöven N, Cheatum CM, Chung HS, Khalil M, Knoester J, Tokmakoff A. Two-dimensional infrared spectroscopy of antiparallel beta-sheet secondary structure. J Am Chem Soc. 2004 Jun 30; 126 (25; 126; 2004 Jun 30):7981-90. [Full Text/Abstract]