U.S. Department of Health and Human Services
Istvan Botos

 Contact Info

Tel: 301-443-3595
Email: botosi@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2005–Present
  • Postdoctoral FellowFrederick Cancer Research and Development Center, NCI, NIH1999–2005
  • Research FellowHungarian Academy of Sciences, Institute of Biophysics1990–1992
  • Ph.D.Texas A&M University1999
  • M.Sc.University of Bucharest, Department of Biology1990

 Related Links


Istvan Botos, Ph.D.

Staff Scientist, Office of the Chief, Laboratory of Molecular Biology
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Botos I, Segal DM, Davies DR. The structural biology of Toll-like receptors. Structure. 2011 Apr 13; 19 (19; 4; 2011 Apr 13):447-59. [Full Text/Abstract]
Botos I, Liu L, Wang Y, Segal DM, Davies DR. The toll-like receptor 3:dsRNA signaling complex. Biochim Biophys Acta. 2009 Sep-Oct; 1789 (2009 Sep-Oct; 9-10; 1789):667-74. [Full Text/Abstract]
Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science. 2008 Apr 18; 320 (2008 Apr 18; 5874; 320):379-81. [Full Text/Abstract]
Moulaei T, Botos I, Ziółkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A. Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci. 2007 Dec; 16 (16; 2007 Dec; 12):2756-60. [Full Text/Abstract]