U.S. Department of Health and Human Services
Istvan Botos

 Contact Info

Tel: 301-443-3595
Email: botosi@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2005–Present
  • Postdoctoral FellowFrederick Cancer Research and Development Center, NCI, NIH1999–2005
  • Research FellowHungarian Academy of Sciences, Institute of Biophysics1990–1992
  • Ph.D.Texas A&M University1999
  • M.Sc.University of Bucharest, Department of Biology1990

 Related Links


Istvan Botos, Ph.D.

Staff Scientist, Office of the Chief, Laboratory of Molecular Biology
  • Structural Biology

​Research Images

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Structure of the TLR3/dsRNA complexThis image depicts the structure of the TLR3/dsRNA complex.  (A) The molecular surface of TLR3 dimer is shown (green) with bound dsRNA (Liu et al., 2008)(3CIY).  The interaction of the C-terminal capping motifs stabilizes the TLR3 dimer.  (B) The top view is shown.  Figure 5 Structure, 2011.Structure of the TLR3/dsRNA complexEnlarge
Model of the full-length dsRNA:TLR3 signaling complexThis image depicts a model of the full-length dsRNA:TLR3 signaling complex.  The proximity of the two C-termini permits association of the trans-membrane helices and the dimerization of the cytoplasmic TIR domains. Figure 4 Science, 2008.Model of the full-length dsRNA:TLR3 signaling complexEnlarge
Structure of the TLR3-ECDThis image depicts the structure of the TLR3-ECD.  The TLR3-ECD consists of 23 LRRs that form a horseshoe-like solenoid with two capping motifs.  The molecule has a surprisingly flat profile. There are 11 visible glycosylation sites.  Figure 1 BBA, 2009.Structure of the TLR3-ECDEnlarge