U.S. Department of Health and Human Services
James Balow

 Contact Info

Tel: 301-496-4181
Email: jimb@mail.nih.gov

 Select Experience

  • Clinical Immunology FellowshipNIAID, NIH1972–1975
  • Internal Medicine and Nephrology FellowshipsGeorgetown University1969–1972
  • M.D.University of Minnesota1968
  • B.S.College of St. Thomas1964

 Related Links


    James E. Balow, M.D.

    Clinical Director, Division of Intramural Research
    Director of Translational Research, Division of Intramural Research​
    Senior Investigator, Kidney Disease Section, Kidney Disease Branch

    Specialties: Clinical Research​​

    James E. Balow, M.D.

    Senior Investigator, Kidney Disease SectionKidney Diseases Branch
    Clinical Director, Division of Intramural Research
    Director of Translational Research, Division of Intramural Research
    Clinical Director, Office of Clinical Director
    • Clinical Research
    Research Summary/In Plain Language

    Research Summary

    Current Research

    The focus of our research is the natural history, pathogenesis, and treatment of immunologically mediated glomerular diseases, particularly lupus nephritis and membranous nephropathy. Previous findings from our research section have demonstrated that intermittent pulse cyclophosphamide therapy has the highest therapeutic index among currently available immunosuppressive drug therapies in the treatment of proliferative forms of lupus nephritis.

    In light of the intrinsic risk of gonadal toxicity of pulse cyclophosphamide therapy, we are conducting studies designed to examine the efficacy and toxicity profile of alternative immunomodulating agents, particularly combinations of rituximab, calcineurin inhibitors, and antimetabolite drugs.

    We are currently conducting pilot studies in membranous nephropathy to evaluate the safety and efficacy of combined rituximab and cyclosporine.