U.S. Department of Health and Human Services
 

 Contact Info

 
Tel: 301-496-9893
Email: jmsayer@niddk.nih.gov
 

 Select Experience

 
  • Research ChemistLCP, NIDDK, NIH2007-present
  • Research ChemistLBC, NIDDK, NIH1985-2007
  • Special ExpertLBC, NIDDK, NIH1979-1985
  • Guest WorkerLBC, NIDDK, NIH1979-1983
  • Senior Research AssociateBrandeis University1969- 1974
  • NIH Postdoctoral FellowBrandeis University1967-1969
  • Ph.D.Yale University1967
 

 Related Links

 

    ​

    Jane M. Sayer, Ph.D.

    Research Chemist, Office of the Chief, Laboratory of Chemical Physics
    Specialties
    • Chemistry/Chemical Biology
    • Molecular Biology/Biochemistry

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Burke L, Sayer J, Morris-Thompson T, Marks-Maran D. Recruiting competent newly qualified nurses in the London region: An exploratory study. Nurse Educ Today. 2014 Oct; 34 (2014 Oct; 10; 34):1283-9. [Full Text/Abstract]
    Newton P, Chandler V, Morris-Thomson T, Sayer J, Burke L. Exploring selection and recruitment processes for newly qualified nurses: a sequential-explanatory mixed-method study. J Adv Nurs. 2014 Jun 24; 71 (71; 2014 Jun 24; 1):54-64. [Full Text/Abstract]
    Laker C, Callard F, Flach C, Williams P, Sayer J, Wykes T. The challenge of change in acute mental health services: measuring staff perceptions of barriers to change and their relationship to job status and satisfaction using a new measure (VOCALISE). Implement Sci. 2014 Feb 20; 9 (2014 Feb 20; 9; 1):23. [Full Text/Abstract]
    Sayer JM, Aniana A, Louis JM. Mechanism of dissociative inhibition of HIV protease and its autoprocessing from a precursor. J Mol Biol. 2012 Sep 14; 422 (2012 Sep 14; 422; 2):230-44. [Full Text/Abstract]
    Agniswamy J, Sayer JM, Weber IT, Louis JM. Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease. Biochemistry. 2012 Feb 7; 51 (2012 Feb 7; 5; 51):1041-50. [Full Text/Abstract]
    Louis JM, Aniana A, Weber IT, Sayer JM. Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors. Proc Natl Acad Sci U S A. 2011 May 31; 108 (108; 22; 2011 May 31):9072-7. [Full Text/Abstract]
    Louis JM, Zhang Y, Sayer JM, Wang YF, Harrison RW, Weber IT. The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts. Biochemistry. 2011 May 31; 50 (50; 21; 2011 May 31):4786-95. [Full Text/Abstract]
    Sayer JM, Agniswamy J, Weber IT, Louis JM. Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance. Protein Sci. 2010 Nov; 19 (2010 Nov; 19; 11):2055-72. [Full Text/Abstract]
    Louis JM, Ishima R, Aniana A, Sayer JM. Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease. Protein Sci. 2009 Dec; 18 (12; 18; 2009 Dec):2442-53. [Full Text/Abstract]
    Sayer JM, Louis JM. Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin. Proteins. 2009 May 15; 75 (2009 May 15; 3; 75):556-68. [Full Text/Abstract]
    Sayer JM, Liu F, Ishima R, Weber IT, Louis JM. Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease. J Biol Chem. 2008 May 9; 283 (2008 May 9; 19; 283):13459-70. [Full Text/Abstract]