U.S. Department of Health and Human Services

 Contact Info

Tel: 301-496-9893
Email: jmsayer@niddk.nih.gov

 Select Experience

  • Research ChemistLCP, NIDDK, NIH2007-present
  • Research ChemistLBC, NIDDK, NIH1985-2007
  • Special ExpertLBC, NIDDK, NIH1979-1985
  • Guest WorkerLBC, NIDDK, NIH1979-1983
  • Senior Research AssociateBrandeis University1969- 1974
  • NIH Postdoctoral FellowBrandeis University1967-1969
  • Ph.D.Yale University1967

 Related Links


    Jane M. Sayer, Ph.D.

    Research Chemist, Office of the Chief, Laboratory of Chemical Physics
    • Chemistry/Chemical Biology
    • Molecular Biology/Biochemistry
    Research Summary/In Plain Language

    Research in Plain Language

    We examine how proteins interact with each other and with small molecules such as drugs.  Enzymes are proteins that speed molecular reactions in cells and other biological systems.  Our research focuses on the enzyme, retroviral protease.  Some viruses require this enzyme to grow and reproduce.  These include HIV, the virus that causes AIDS.  The most current HIV treatments include at least one drug that blocks this enzyme’s activity.  Although the treatments are effective, viruses can rapidly develop resistance to these drugs.  Our research may help develop new treatments that fight drug-resistant viruses.

    Prior to 2007, I studied the chemistry of environmental pollutants that cause cancer.  We examined how these chemicals are changed by processes that occur in the body.  The changes enable them to interact with DNA.  These interactions damage DNA and can trigger cancer.