U.S. Department of Health and Human Services

 Contact Info

Tel: 301-451-1850
Email: zhangjh@helix.nih.gov

 Select Experience

  • Staff ScientistMDB, NIDDK, NIH2002-present
  • Research FellowMDB, NIDDK, NIH2000-2002
  • Visiting AssociateMDB, NIDDK, NIH1998-2000
  • Postdoctoral AssociateThe Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology/WSU1996-1998
  • Ph.D.Washington State University (WSU)1996
  • M.S.Nanjing Agricultural University1986

 Related Links

    • Cancer Biology
    • Molecular Biology/Biochemistry
    • Neuroscience/Neurophysiology/Neurodevelopment


    A selection of recent and significant publications can be viewed below.

    Xu J, Chen YQ, Zhang HJ, Tang L, Wang K, Zhang JH, Chen XS, Mao ZG. Production of citric acid using its extraction wastewater treated by anaerobic digestion and ion exchange in an integrated citric acid-methane fermentation process. Bioprocess Biosyst Eng. 2014 Aug; 37 (8; 2014 Aug; 37):1659-68. [Full Text/Abstract]
    Ma L, Xue HB, Guan XH, Shu CM, Wang F, Zhang JH, An RZ. The Imbalance of Th17 cells and CD4(+) CD25(high) Foxp3(+) Treg cells in patients with atopic dermatitis. J Eur Acad Dermatol Venereol. 2014 Aug; 28 (28; 8; 2014 Aug):1079-86. [Full Text/Abstract]
    Liao Q, Li NN, Mao XY, Chang XL, Zhao DM, Zhang JH, Yu WJ, Tan EK, Peng R. MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese. Acta Neurol Scand. 2014 Jul; 130 (130; 2014 Jul; 1):e30-4. [Full Text/Abstract]
    Chen L, Guo S, Xu M, Wu LX, Zhang JH. Effect of Diclofenac on the Pharmacokinetics of Moxifloxacin in Rats. Drug Res (Stuttg). 2014 Jul; 64 (7; 64; 2014 Jul):343-7. [Full Text/Abstract]
    Ma HJ, Zhang JH, Xia XD, Xu MH, Ning J, Li JH. Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives as potential pigment biosynthesis inhibitors. Pest Manag Sci. 2014 Jun; 70 (6; 70; 2014 Jun):946-52. [Full Text/Abstract]
    Ju XD, Guo Y, Wang NN, Huang Y, Lai MM, Zhai YH, Guo YG, Zhang JH, Cao RJ, Yu HL, Cui L, Li YT, Wang XZ, Ding YQ, Zhu XJ. Both Myosin-10 Isoforms Are Required for Radial Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2014 May; 24 (2014 May; 24; 5):1259-68. [Full Text/Abstract]
    Chen S, Feng H, Sherchan P, Klebe D, Zhao G, Sun X, Zhang J, Tang J, Zhang JH. Controversies and evolving new mechanisms in subarachnoid hemorrhage. Prog Neurobiol. 2014 Apr; 115 (115; 2014 Apr):64-91. [Full Text/Abstract]
    Wang P, Li H, Wang Y, Zhang JH, Dai X, Chang J, Hu BW, Cai WZ. The mitochondrial genome of the plant bug Apolygus lucorum (Hemiptera: Miridae): Presently known as the smallest in Heteroptera. Insect Sci. 2014 Apr; 21 (2; 21; 2014 Apr):159-73. [Full Text/Abstract]
    Wang L, Zhu SJ, Wang HY, Qu SN, Zhang YL, Zhang JH, Chen QD, Xu HL, Han W, Yang B, Sun HB. Common origin of green luminescence in carbon nanodots and graphene quantum dots. ACS Nano. 2014 Mar 25; 8 (8; 2014 Mar 25; 3):2541-7. [Full Text/Abstract]
    Xu J, Zhu MD, Zhang X, Tian H, Zhang JH, Wu XB, Gao YJ. NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice. J Neuroinflammation. 2014 Mar 1; 11 (2014 Mar 1; 11):38. [Full Text/Abstract]
    Zhang JH, Chou SY, Deily ME, Lien HM. Hospital ownership and drug utilization under a global budget: a quantile regression analysis. Int Health. 2014 Mar; 6 (2014 Mar; 6; 1):62-9. [Full Text/Abstract]
    Manaenko A, Lekic T, Barnhart M, Hartman R, Zhang JH. Inhibition of transforming growth factor-β attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage. Stroke. 2014 Mar; 45 (2014 Mar; 3; 45):828-34. [Full Text/Abstract]
    Li MS, Sun Y, Chen YH, Zhang JH. [Establishment and application of pollutant discharge-environment quality model]. Huan Jing Ke Xue. 2014 Mar; 35 (2014 Mar; 35; 3):1198-204. [Full Text/Abstract]
    Ma XY, Liu SB, Lu L, Li SF, Xie JJ, Zhang LY, Zhang JH, Luo XG. Relative bioavailability of iron proteinate for broilers fed a casein-dextrose diet. Poult Sci. 2014 Mar; 93 (2014 Mar; 93; 3):556-63. [Full Text/Abstract]
    Zhang H, Yang Q, Qin QL, Zhu W, Zhang ZF, Li YN, Zhang N, Zhang JH. Genomic sequence analysis of Helicoverpa armigera nucleopolyhedrovirus isolated from Australia. Arch Virol. 2014 Mar; 159 (2014 Mar; 3; 159):595-601. [Full Text/Abstract]
    Zhang H, Yang Q, Qin QL, Zhu W, Zhang ZF, Li YN, Zhang N, Zhang JH. Genomic sequence analysis of Helicoverpa armigera nucleopolyhedrovirus isolated from Australia. Arch Virol. 2014 Mar; 159 (2014 Mar; 3; 159):595-601. [Full Text/Abstract]
    Shao JH, Cui Y, Zhao MY, Wu CF, Liu YF, Zhang JH. Purification, characterization, and bioactivity of a new analgesic-antitumor peptide from Chinese scorpion Buthus martensii Karsch. Peptides. 2014 Mar; 53 (2014 Mar; 53):89-96. [Full Text/Abstract]
    Fried LF, Emanuele N, Zhang JH. Combined angiotensin inhibition in diabetic nephropathy. N Engl J Med. 2014 Feb 20; 370 (2014 Feb 20; 8; 370):779. [Full Text/Abstract]
    Nowrangi DS, Tang J, Zhang JH. Argon gas: a potential neuroprotectant and promising medical therapy. Med Gas Res. 2014 Feb 17; 4 (4; 2014 Feb 17; 1):3. [Full Text/Abstract]
    Wang M, Zhang JH, Applegate RL 2nd. Adverse effect of inhalational anesthetics on the developing brain. Med Gas Res. 2014 Feb 14; 4 (2014 Feb 14; 4; 1):2. [Full Text/Abstract]
    Jiang Q, Mei J, Gong XD, Xu JL, Zhang JH, Teng S, Lin DZ, Dong YJ. Importance of the rice TCD9 encoding α subunit of chaperonin protein 60 (Cpn60α) for the chloroplast development during the early leaf stage. Plant Sci. 2014 Feb; 215-216 (215-216; 2014 Feb):172-9. [Full Text/Abstract]
    Zhang JH, Yu LX, Yao QZ, Tian L. [Mixing behavior of nutrients in different seasons at Liaohe Estuary]. Huan Jing Ke Xue. 2014 Feb; 35 (35; 2; 2014 Feb):569-76. [Full Text/Abstract]
    Zhang JH, Li FC, Wang Y, Xiong DH. Soil Organic Carbon Stock and Distribution in Cultivated Land Converted to Grassland in a Subtropical Region of China. Environ Manage. 2014 Feb; 53 (2; 2014 Feb; 53):274-83. [Full Text/Abstract]
    Liu Q, Jin Y, Wang K, Meng XX, Yang Y, Yang Z, Zhao YS, Zhao MY, Zhang JH. Study of the residues involved in the binding of β1 to β3 subunits in the sodium channel. C R Biol. 2014 Feb; 337 (337; 2; 2014 Feb):73-7. [Full Text/Abstract]
    Kong B, Yang T, Chen L, Kuang YQ, Gu JW, Xia X, Cheng L, Zhang JH. Protein-protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer. J Clin Neurosci. 2014 Feb; 21 (2; 2014 Feb; 21):316-9. [Full Text/Abstract]
    Altay O, Suzuki H, Hasegawa Y, Ostrowski RP, Tang J, Zhang JH. Isoflurane on brain inflammation. Neurobiol Dis. 2014 Feb; 62C (62C; 2014 Feb):365-371. [Full Text/Abstract]
    Ma Q, Chen S, Hu Q, Feng H, Zhang JH, Tang J. NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol. 2014 Feb; 75 (2; 2014 Feb; 75):209-19. [Full Text/Abstract]
    Xu JB, Qi FZ, Xu G, Chen GF, Huang MD, Zhang JH. Adjuvant interferon therapy after surgical treatment for hepatitis B/C virus-related hepatocellular carcinoma: A meta-analysis. Hepatol Res. 2014 Feb; 44 (2; 2014 Feb; 44):209-17. [Full Text/Abstract]
    Hou YF, Liu SJ, Zhang JH, Cheng X, Wang Y. Facile hydrothermal synthesis of TiO2-Bi2WO6 hollow superstructures with excellent photocatalysis and recycle properties. Dalton Trans. 2014 Jan 21; 43 (2014 Jan 21; 43; 3):1025-31. [Full Text/Abstract]
    Zhang M, Zhang JH, Zhang Y, Wang BJ, Xie SM, Yuan LM. Chromatographic study on the high performance separation ability of a homochiral [Cu2(d-Cam)2(4,4'-bpy)]n based-column by using racemates and positional isomers as test probes. J Chromatogr A. 2014 Jan 17; 1325 (2014 Jan 17; 1325):163-70. [Full Text/Abstract]
    Li PS, Fu ZY, Zhang YY, Zhang JH, Xu CQ, Ma YT, Li BL, Song BL. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nat Med. 2014 Jan; 20 (20; 2014 Jan; 1):80-6. [Full Text/Abstract]
    Zhang JH, Zeng WJ, Xu PR, Zhang WP. [Leptin gene C2549A polymorphism in minority Hui and Uygur children with obesity]. Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jan; 16 (16; 2014 Jan; 1):20-4. [Full Text/Abstract]
    Ma L, Xue HB, Guan XH, Shu CM, Zhang JH, Yu J. Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clin Exp Immunol. 2014 Jan; 175 (175; 2014 Jan; 1):25-31. [Full Text/Abstract]
    Yang T, Kong B, Kuang YQ, Cheng L, Gu JW, Zhang JH, Shu HF, Yu SX, He WQ, Xing XM, Huang HD. Overexpression of MACC1 protein and its clinical implications in patients with glioma. Tumour Biol. 2014 Jan; 35 (35; 2014 Jan; 1):815-9. [Full Text/Abstract]
    Wang L, Wang HY, Wang Y, Zhu SJ, Zhang YL, Zhang JH, Chen QD, Han W, Xu HL, Yang B, Sun HB. Direct observation of quantum-confined graphene-like States and novel hybrid States in graphene oxide by transient spectroscopy. Adv Mater. 2013 Dec 3; 25 (2013 Dec 3; 25; 45):6539-45. [Full Text/Abstract]
    Zhang JH, Huo YZ, Zhang ZL, Yu KF, He Q, Zhang LH, Yang LL, Xu R, He PM. Variations of morphology and photosynthetic performances of Ulva prolifera during the whole green tide blooming process in the Yellow Sea. Mar Environ Res. 2013 Dec; 92 (92; 2013 Dec):35-42. [Full Text/Abstract]
    Yang Y, Liu YJ, Tang ST, Yang L, Yang J, Cao GQ, Zhang JH, Wang XX, Mao YZ. Elevated Th17 cells accompanied by decreased regulatory T cells and cytokine environment in infants with biliary atresia. Pediatr Surg Int. 2013 Dec; 29 (2013 Dec; 12; 29):1249-60. [Full Text/Abstract]
    Zhang YL, Liang W, Chen ZM, Zhang HM, Zhang JH, Weng XQ, Yang SC, Zhang L, Shen LJ, Zhang YL. Validity and reliability of Patient Health Questionnaire-9 and Patient Health Questionnaire-2 to screen for depression among college students in China. Asia Pac Psychiatry. 2013 Dec; 5 (2013 Dec; 4; 5):268-75. [Full Text/Abstract]
    Chen S, Ma Q, Krafft PR, Chen Y, Tang J, Zhang J, Zhang JH. P2X7 Receptor Antagonism Inhibits p38 Mitogen-Activated Protein Kinase Activation and Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. Crit Care Med. 2013 Dec; 41 (2013 Dec; 41; 12):e466-74. [Full Text/Abstract]
    Chen XS, Ren XD, Zeng X, Zhao FL, Tang L, Zhang HJ, Zhang JH, Mao ZG. Enhancement of ε-poly-L-lysine production coupled with precursor L-lysine feeding in glucose-glycerol co-fermentation by Streptomyces sp. M-Z18. Bioprocess Biosyst Eng. 2013 Dec; 36 (2013 Dec; 36; 12):1843-9. [Full Text/Abstract]
    Huang JS, Zhao MD, Shi JM, Zhang JH, Li B, Fan W, Zhou YL. Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene. Genet Mol Res. 2013 Nov 22; 12 (4; 12; 2013 Nov 22):5842-50. [Full Text/Abstract]
    Zhang JH, Kang ZB, Ardayfio O, Ho PI, Smith T, Wallace I, Bowes S, Hill WA, Auld DS. Application of Titration-Based Screening for the Rapid Pilot Testing of High-Throughput Assays. J Biomol Screen. 2013 Nov 18; 19 (19; 2013 Nov 18; 5):651-60. [Full Text/Abstract]
    Zhou GX, Chen X, Zhang JH, Zhu JQ, Wang YB, Wang ZQ. MR lymphangiography at 3.0 Tesla to assess the function of inguinal lymph node in low extremity lymphedema. J Magn Reson Imaging. 2013 Nov 15; 40 (2013 Nov 15; 40; 6):1430-6. [Full Text/Abstract]
    Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W, Leehey DJ, McCullough PA, O'Connor T, Palevsky PM, Reilly RF, Seliger SL, Warren SR, Watnick S, Peduzzi P, Guarino P, VA NEPHRON-D Investigators. Combined Angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med. 2013 Nov 14; 369 (20; 369; 2013 Nov 14):1892-903. [Full Text/Abstract]
    Zhang YC, Liu ZC, Yang R, Zhang JH, Yan SJ, Lin J. Regioselective construction of 1,3-diazaheterocycle fused [1,2-a][1,8]naphthyridine derivatives via cascade reaction of quinolines with heterocyclic ketene aminals: a joint experimental-computational approach. Org Biomol Chem. 2013 Nov 14; 11 (42; 2013 Nov 14; 11):7276-88. [Full Text/Abstract]
    Zhou Y, Li YS, Meng XY, Zhang YY, Yang L, Li ZH, Zhang JH, Wang XR, Liu JQ, Lu SY, Ren HL, Hu P, Liu ZS. Production of a monoclonal antibody and development of an immunoassay for detection of Cr(III) in water samples. Chemosphere. 2013 Nov; 93 (93; 10; 2013 Nov):2467-72. [Full Text/Abstract]
    Topkoru BC, Altay O, Duris K, Krafft PR, Yan J, Zhang JH. Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage. Stroke. 2013 Nov; 44 (44; 2013 Nov; 11):3189-94. [Full Text/Abstract]
    Xi YL, Dai WY, Xu R, Zhang JH, Chen KQ, Jiang M, Wei P, Ouyang PK. Ultrasonic pretreatment and acid hydrolysis of sugarcane bagasse for succinic acid production using Actinobacillus succinogenes. Bioprocess Biosyst Eng. 2013 Nov; 36 (36; 2013 Nov; 11):1779-85. [Full Text/Abstract]
    Zhou Y, Song F, Li YS, Liu JQ, Lu SY, Ren HL, Liu ZS, Zhang YY, Yang L, Li ZH, Zhang JH, Wang XR. Double-antibody based immunoassay for the detection of β-casein in bovine milk samples. Food Chem. 2013 Nov 1; 141 (2013 Nov 1; 141; 1):167-73. [Full Text/Abstract]
    Tan CM, Chen RJ, Zhang JH, Gao XL, Li LH, Wang PR, Deng XJ, Xu ZJ. OsPOP5, a prolyl oligopeptidase family gene from rice confers abiotic stress tolerance in Escherichia coli. Int J Mol Sci. 2013 Oct 10; 14 (14; 2013 Oct 10; 10):20204-19. [Full Text/Abstract]