U.S. Department of Health and Human Services

 Contact Info

Tel: 301-827-4417
Email: jianxinh@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH1999–Present
  • PostdoctoralUniversity of South Carolina1995–1999
  • Ph.D.Chinese Academy of Sciences, Shanghai Institute of Biochemistry1995

 Related Links


    • Molecular Biology/Biochemistry
    Research Summary/In Plain Language

    Research in Plain Language

    There is a large family of proteins (receptors) on a cell surface that sense signaling molecules outside the cell and transmit the signal inside, leading to chain reactions and cellular responses. These receptors are important drug targets, and therefore, knowledge about the structure and function of these receptors will lead to more informed drug design. Through my research, I try to answer the following main questions:

    • How do receptors pass signals to other proteins inside the cell that they directly contact?
    • Many receptors exist as pairs on the cell surface. Why and how are these pairs formed?

    Biochemical methods are used to identify point-to-point interactions between proteins. The results collected from these studies will teach us more about the structure and function of receptors.