There is a large family of proteins (receptors) on a cell surface that sense signaling molecules outside the cell and transmit the signal inside, leading to chain reactions and cellular responses. These receptors are important drug targets, and therefore, knowledge about the structure and function of these receptors will lead to more informed drug design. Through my research, I try to answer the following main questions:
- How do receptors pass signals to other proteins inside the cell that they directly contact?
- Many receptors exist as pairs on the cell surface. Why and how are these pairs formed?
Biochemical methods are used to identify point-to-point interactions between proteins. The results collected from these studies will teach us more about the structure and function of receptors.