U.S. Department of Health and Human Services
John Hanover

 Contact Info

Tel: 301-496-0943
Email: jah@helix.nih.gov

 Select Experience

  • Ph.D.Johns Hopkins University School of Medicine1981
  • B.S.University of Tulsa1976

 Related Links

  • Cancer Biology
  • Cell Biology/Cell Signaling
  • Chemistry/Chemical Biology
  • Chromosome Biology/Epigenetics
  • Developmental Biology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Stem Cells/Induced Pluripotent Stem Cells
  • Systems Biology


A selection of recent and significant publications can be viewed below.

Bond MR, Hanover JA. A little sugar goes a long way: the cell biology of O-GlcNAc. J Cell Biol. 2015 Mar 30; 208 (7; 2015 Mar 30; 208):869-80. [Full Text/Abstract]
Keembiyehetty C, Love DC, Harwood KR, Gavrilova O, Comly ME, Hanover JA. Conditional Knock-out Reveals a Requirement for O-Linked N-Acetylglucosaminase (O-GlcNAcase) in Metabolic Homeostasis. J Biol Chem. 2015 Jan 16; 290 (2015 Jan 16; 11; 290):7097-7113. [Full Text/Abstract]
Lewis BA, Hanover JA. O-GlcNAc and the epigenetic regulation of gene expression. J Biol Chem. 2014 Oct 21; 289 (50; 2014 Oct 21; 289):34440-34448. [Full Text/Abstract]
Vigetti D, Deleonibus S, Moretto P, Bowen T, Fischer JW, Grandoch M, Oberhuber A, Love DC, Hanover JA, Cinquetti R, Karousou E, Viola M, D'Angelo ML, Hascall VC, De Luca G, Passi A. Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via Protein O-GlcNAcylation. J Biol Chem. 2014 Sep 2; 289 (2014 Sep 2; 42; 289):28816-26. [Full Text/Abstract]
Abd-Elmoniem KZ, Bakalov VK, Matta JR, Muldoon N, Hanover JA, Bondy CA, Gharib AM. X Chromosome Parental Origin and Aortic Stiffness in Turner Syndrome. Clin Endocrinol (Oxf). 2014 Sep; 81 (81; 3; 2014 Sep):467-70. [Full Text/Abstract]
Kim EJ, Bond MR, Love DC, Hanover JA. Chemical tools to explore nutrient-driven O-GlcNAc cycling. Crit Rev Biochem Mol Biol. 2014 Jul-Aug; 49 (49; 4; 2014 Jul-Aug):327-42. [Full Text/Abstract]
Stichelen SO, Abramowitz LK, Hanover JA. X Marks the Spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?. Biochem Biophys Res Commun. 2014 Jun 21; 453 (453; 2; 2014 Jun 21):201-207. [Full Text/Abstract]
Kim EJ, Abramowitz LK, Bond MR, Love DC, Ahn JS, Kang DW, Leucke HF, Kang DW, Hanover JA. Versatile O-GlcNAc Transferase Assay for High-throughput Identification of Enzyme Variants, Substrates, and Inhibitors. Bioconjug Chem. 2014 Jun 18; 25 (25; 6; 2014 Jun 18):1025-30. [Full Text/Abstract]
Harwood KR, Hanover JA. Nutrient-driven O-GlcNAc cycling - think globally but act locally. J Cell Sci. 2014 May 1; 127 (127; 2014 May 1; Pt 9):1857-67. [Full Text/Abstract]
Sarker MM, Zhou M, Rameshwar P, Hanover JA. Functions and Roles of Proteins: Diabetes as a Paradigm. Prog Biophys Mol Biol. 2014 Jan; 114 (2014 Jan; 114; 1):2-7. [Full Text/Abstract]
Abramowitz LK, Olivier-Van Stichelen S, Hanover JA. Chromosome imbalance as a driver of sex disparity in disease. J Genomics. 2014 Apr 1; 2 (2; 2014 Apr 1):77-88. [Full Text/Abstract]
Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem. 2012 Jul 6; 287 (28; 287; 2012 Jul 6):23549-61. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol. 2012 Apr 23; 13 (2012 Apr 23; 13; 5):312-21. [Full Text/Abstract]
Keembiyehetty CN, Krzeslak A, Love DC, Hanover JA. A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. J Cell Sci. 2011 Aug 15; 124 (124; 2011 Aug 15; Pt 16):2851-60. [Full Text/Abstract]
Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW. O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics. 2011 Jun; 188 (188; 2; 2011 Jun):369-82. [Full Text/Abstract]
Hanover JA. A versatile sugar transferase makes the cut. Cell. 2011 Feb 4; 144 (144; 3; 2011 Feb 4):321-3. [Full Text/Abstract]
Hanover JA. Epigenetics gets sweeter: O-GlcNAc joins the "histone code". Chem Biol. 2010 Dec 22; 17 (17; 12; 2010 Dec 22):1272-4. [Full Text/Abstract]
Sekine O, Love DC, Rubenstein DS, Hanover JA. Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis. J Biol Chem. 2010 Dec 3; 285 (2010 Dec 3; 49; 285):38684-91. [Full Text/Abstract]
Kim EJ, Love DC, Darout E, Abdo M, Rempel B, Withers SG, Rablen PR, Hanover JA, Knapp S. OGA inhibition by GlcNAc-selenazoline. Bioorg Med Chem. 2010 Oct 1; 18 (2010 Oct 1; 19; 18):7058-64. [Full Text/Abstract]
Love DC, Krause MW, Hanover JA. O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol. 2010 Aug; 21 (6; 2010 Aug; 21):646-54. [Full Text/Abstract]
Love DC, Ghosh S, Mondoux MA, Fukushige T, Wang P, Wilson MA, Iser WB, Wolkow CA, Krause MW, Hanover JA. Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A. 2010 Apr 20; 107 (2010 Apr 20; 107; 16):7413-8. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta. 2010 Feb; 1800 (2; 1800; 2010 Feb):80-95. [Full Text/Abstract]
Lazarus BD, Love DC, Hanover JA. O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol. 2009 Nov; 41 (41; 2009 Nov; 11):2134-46. [Full Text/Abstract]
Hanover JA, Love DC, Prinz WA. Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation. J Biol Chem. 2009 May 8; 284 (19; 284; 2009 May 8):12593-7. [Full Text/Abstract]
Chen S, Whetstine JR, Ghosh S, Hanover JA, Gali RR, Grosu P, Shi Y. The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A. 2009 Feb 3; 106 (106; 2009 Feb 3; 5):1496-501. [Full Text/Abstract]
Krawczyk E, Suprynowicz FA, Liu X, Dai Y, Hartmann DP, Hanover J, Schlegel R. Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins. Am J Pathol. 2008 Sep; 173 (173; 3; 2008 Sep):682-8. [Full Text/Abstract]
Krawczyk E, Hanover JA, Schlegel R, Suprynowicz FA. Karyopherin beta3: a new cellular target for the HPV-16 E5 oncoprotein. Biochem Biophys Res Commun. 2008 Jul 11; 371 (4; 2008 Jul 11; 371):684-8. [Full Text/Abstract]
Wesierska-Gadek J, Klima A, Ranftler C, Komina O, Hanover J, Invernizzi P, Penner E. Characterization of the antibodies to p62 nucleoporin in primary biliary cirrhosis using human recombinant antigen. J Cell Biochem. 2008 May 1; 104 (2008 May 1; 104; 1):27-37. [Full Text/Abstract]