U.S. Department of Health and Human Services
Alejandro Negrete

 Contact Info

Tel: 301-402-2325
Email: negretea@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2008–Present
  • Postdoctoral ResearcherNHLBI, NIH2003–2008
  • Ph.D. in Chemical EngineeringUniversity of Birmingham, UK2003
  • M.S. in BiotechnologyMonterrey Tech (ITESM), Mexico1998

 Related Links


Juan Alejandro Negrete Virgen, Ph.D.

Staff Scientist, Biotechnology Core
  • Biotechnology
Research Summary/In Plain Language

Research Summary

Research Goal

To improve the bacterial response to environmental changes by better understanding the physiological role of non-coding small RNAs

Current Research

​Current research is focused on studying the capability of E. coli to respond to stress growth conditions such as glucose concentration, osmolarity, pH, dissolved oxygen and temperature by determining the physiological role of the non-coding small RNAs (sRNAs). The objective is to perform genetic manipulation of sRNAs to increase the bacteria resistance to environmental stress conditions and consequently the efficiency of their growth and production capability.

Applying our Research

Providing large amounts of bioproducts will increase availability and lower costs.

Need for Further Study

Current research related to small RNAs is concentrated on the molecular interaction and not on the physiological aspects. The physiological role of these molecules needs further study. Based on this, it will be possible to modify the producing strains.