Current research is focused on studying the capability of E. coli to respond to stress growth conditions such as glucose concentration, osmolarity, pH, dissolved oxygen and temperature by determining the physiological role of the non-coding small RNAs (sRNAs). The objective is to perform genetic manipulation of sRNAs to increase the bacteria resistance to environmental stress conditions and consequently the efficiency of their growth and production capability.
Current research related to small RNAs is concentrated on the molecular interaction and not on the physiological aspects. The physiological role of these molecules needs further study. Based on this, it will be possible to modify the producing strains.