U.S. Department of Health and Human Services
Jurrien Dean

 Contact Info

Tel: 301-496-2738
Email: jurrien.dean@nih.gov

 Select Experience

  • M.D.College of Physicians and Surgeons, Columbia University1973
  • B.A.Columbia College, Columbia University1969

 Related Links

  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Molecular Biology/Biochemistry

​Research Images

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Mouse FertilizationFertilization occurs in the ampulla of the oviduct where the fertilizing sperm encounters an ovulated egg. After initial binding to the zona pellucida, the sperm penetrates through the zona matrix to fuse with the egg plasma membrane. The subsequent cortical granule reaction leads to a potent block to polyspermy.Mouse FertilizationEnlarge
Early Mouse DevelopmentMaternal RNA and proteins accumulate during oocyte growth. The zona pellucida that surrounds ovulated eggs (green) is modified following fertilization (red) to prevent polyspermy. Activation of the embryonic genome occurs in the 2-cell embryo and, following the third cell division, embryos compact to form morulae and then blastocysts that implant on the wall of the uterus.Early Mouse DevelopmentEnlarge