U.S. Department of Health and Human Services
Kai Ge

 Contact Info

Tel: 301-451-1998
Email: kai.ge@nih.gov

 Select Experience

  • Postdoctoral FellowThe Rockefeller University2000–2003
  • Postdoctoral FellowThe Wistar Institute1997–2000
  • Ph.D.Shanghai Institute of Biochemistry, Chinese Academy of Sciences1997
  • B.S.Fudan University1992

 Related Links

  • Cell Biology/Cell Signaling
  • Chromosome Biology/Epigenetics
  • Computational Biology/Bioinformatics/Biostatistics/Mathematics
  • Developmental Biology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Stem Cells/Induced Pluripotent Stem Cells


A selection of recent and significant publications can be viewed below.

Placek K, Hu G, Cui K, Zhang D, Ding Y, Lee JE, Jang Y, Wang C, Konkel JE, Song J, Liu C, Ge K, Chen W, Zhao K. MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping. Nat Immunol. 2017 Jul 31; (2017 Jul 31). [Full Text/Abstract]
Froimchuk E, Jang Y, Ge K. Histone H3 lysine 4 methyltransferase KMT2D. Gene. 2017 Jun 29; 627 (627; 2017 Jun 29):337-342. [Full Text/Abstract]
Northrup D, Yagi R, Cui K, Proctor WR, Wang C, Placek K, Pohl LR, Wang R, Ge K, Zhu J, Zhao K. Histone demethylases UTX and JMJD3 are required for NKT cell development in mice. Cell Biosci. 2017; 7 (2017; 7):25. [Full Text/Abstract]
Lai B, Lee JE, Jang Y, Wang L, Peng W, Ge K. MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis. Nucleic Acids Res. 2017 Apr 8; (2017 Apr 8). [Full Text/Abstract]
Jang Y, Wang C, Zhuang L, Liu C, Ge K. H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability. J Mol Biol. 2016 Dec 21; 429 (2016 Dec 21; 13; 429):2046-2054. [Full Text/Abstract]
Park YK, Ge K. Glucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis. Mol Cell Biol. 2016 Oct 24; 37 (2; 37; 2016 Oct 24). [Full Text/Abstract]
Park YK, Wang L, Giampietro A, Lai B, Lee JE, Ge K. Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis. Mol Cell Biol. 2016 Oct 24; 37 (2; 37; 2016 Oct 24). [Full Text/Abstract]
Wang C, Lee JE, Lai B, Macfarlan TS, Xu S, Zhuang L, Liu C, Peng W, Ge K. Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition. Proc Natl Acad Sci U S A. 2016 Oct 3; 113 (113; 42; 2016 Oct 3):11871-11876. [Full Text/Abstract]
Zhang Z, Christin JR, Wang C, Ge K, Oktay MH, Guo W. Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation. Cell Rep. 2016 Sep 20; 16 (2016 Sep 20; 16; 12):3146-56. [Full Text/Abstract]
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 2016 Jul 20; 535 (2016 Jul 20; 7612; 535):382-7. [Full Text/Abstract]
Yoo KH, Oh S, Kang K, Wang C, Robinson GW, Ge K, Hennighausen L. Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms. Mol Cell Biol. 2016 May 23; 36 (16; 36; 2016 May 23):2108-20. [Full Text/Abstract]
Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L, Chu A, Palii CG, Liu C, Camellato B, Brand M, Ge K, Dilworth FJ. UTX demethylase activity is required for satellite cell-mediated muscle regeneration. J Clin Invest. 2016 Mar 21; 126 (126; 4; 2016 Mar 21):1555-1565. [Full Text/Abstract]
Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, Pflumio F, Hébert J, Couture JF, Perkins TJ, Ge K, Dilworth FJ, Brand M. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. Genes Dev. 2016 Mar 1; 30 (30; 5; 2016 Mar 1):508-21. [Full Text/Abstract]
Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG. KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1; 143 (5; 143; 2016 Mar 1):810-21. [Full Text/Abstract]
Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, Yuan J, Ge K, Montoya G, Nussenzweig A, Choudhary C, Daniel JA. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev. 2016 Jan 7; 30 (2016 Jan 7; 30; 2):149-163. [Full Text/Abstract]
Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L. Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nat Med. 2015 Sep 14; 21 (2015 Sep 14; 21; 10):1190-8. [Full Text/Abstract]
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nat Med. 2015 Sep 14; 21 (2015 Sep 14; 21; 10):1199-208. [Full Text/Abstract]
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014 Nov 5; 5 (2014 Nov 5; 5):5425. [Full Text/Abstract]
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 2014 Jul 27; 514 (514; 7520; 2014 Jul 27):107-111. [Full Text/Abstract]
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY. Gcn5 and PCAF Regulate PPARγ and Prdm16 Expression To Facilitate Brown Adipogenesis. Mol Cell Biol. 2014 Jul 28; 34 (19; 2014 Jul 28; 34):3746-53. [Full Text/Abstract]
Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K. Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1. EMBO Rep. 2014 Sep 30; 15 (2014 Sep 30; 15; 11):1192-201. [Full Text/Abstract]
Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul; 243 (243; 7; 2014 Jul):937-47. [Full Text/Abstract]
Lee JE, Ge K. Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis. Cell Biosci. 2014 May 29; 4 (4; 2014 May 29):29. [Full Text/Abstract]
Xu S, Grullon S, Ge K, Peng W. Spatial Clustering for Identification of ChIP-Enriched Regions (SICER) to Map Regions of Histone Methylation Patterns in Embryonic Stem Cells. Methods Mol Biol. 2014; 1150 (1150; 2014):97-111. [Full Text/Abstract]
Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013 Dec 24; 2 (0; 2; 2013 Dec 24):e01503. [Full Text/Abstract]
Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB. A Multifunctional Protein, EWS, Is Essential for Early Brown Fat Lineage Determination. Dev Cell. 2013 Aug 26; 26 (4; 2013 Aug 26; 26):393-404. [Full Text/Abstract]
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 6; 153 (153; 6; 2013 Jun 6):1266-80. [Full Text/Abstract]
Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V. The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. EMBO J. 2013 Apr 17; 32 (2013 Apr 17; 32; 8):1075-86. [Full Text/Abstract]
Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K. H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2013 Feb 7; 12 (2013 Feb 7; 2; 12):180-92. [Full Text/Abstract]
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis. EMBO J. 2013 Jan 9; 32 (32; 2013 Jan 9; 1):45-59. [Full Text/Abstract]
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. Immunity. 2012 Dec 14; 37 (6; 37; 2012 Dec 14):971-85. [Full Text/Abstract]
Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109 (109; 43; 2012 Oct 23):17603-8. [Full Text/Abstract]
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18; 109 (38; 109; 2012 Sep 18):15324-9. [Full Text/Abstract]
Ge K. Epigenetic regulation of adipogenesis by histone methylation. Biochim Biophys Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819):727-32. [Full Text/Abstract]
Cho YW, Hong S, Ge K. Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex. Methods Mol Biol. 2012; 809 (2012; 809):465-72. [Full Text/Abstract]
Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res. 2012 Jan 1; 72 (72; 1; 2012 Jan 1):315-24. [Full Text/Abstract]
Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011 Jan 19; 30 (30; 2; 2011 Jan 19):249-62. [Full Text/Abstract]
Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science. 2010 Aug 20; 329 (329; 2010 Aug 20; 5994):917-23. [Full Text/Abstract]
Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, Hong S, Blais A, Brand M, Ge K, Dilworth FJ. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J. 2010 Apr 21; 29 (8; 29; 2010 Apr 21):1401-11. [Full Text/Abstract]
Wang L, Jin Q, Lee JE, Su IH, Ge K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107 (2010 Apr 20; 107; 16):7317-22. [Full Text/Abstract]
Mishra A, Zhu XG, Ge K, Cheng SY. Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms. J Mol Endocrinol. 2010 Apr; 44 (4; 44; 2010 Apr):247-55. [Full Text/Abstract]
Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab. 2009 Jul; 10 (2009 Jul; 10; 1):27-39. [Full Text/Abstract]
Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem. 2009 Mar 13; 284 (284; 2009 Mar 13; 11):7284-93. [Full Text/Abstract]
Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol. 2008 Feb; 28 (28; 3; 2008 Feb):1081-91. [Full Text/Abstract]
Rampalli S, Li L, Mak E, Ge K, Brand M, Tapscott SJ, Dilworth FJ. p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nat Struct Mol Biol. 2007 Dec; 14 (14; 2007 Dec; 12):1150-6. [Full Text/Abstract]
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A. 2007 Nov 20; 104 (104; 2007 Nov 20; 47):18439-44. [Full Text/Abstract]
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007 Jul 13; 282 (2007 Jul 13; 28; 282):20395-406. [Full Text/Abstract]
Guermah M, Ge K, Chiang CM, Roeder RG. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol Cell. 2003 Oct; 12 (4; 12; 2003 Oct):991-1001. [Full Text/Abstract]
Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature. 2002 May 30; 417 (417; 2002 May 30; 6888):563-7. [Full Text/Abstract]