U.S. Department of Health and Human Services
Kent Thurber

 Contact Info

Tel: 301-402-4687
Email: thurberk@mail.nih.gov

 Select Experience

  • Staff ScientistLaboratory of Chemical Physics, NIDDK, NIH2005-present
  • Postdoctoral FellowMaterials Magnetic Resonance Group, U.S. Naval Research Laboratory2003-2005
  • Postdoctoral FellowMagnetic Resonance Force Microscopy Group, U.S. Army Research Laboratory1999-2003
  • Ph.D.Massachusetts Institute of Technology1999
  • B.S.Massachusetts Institute of Technology1994

 Related Links

  • Biomedical Engineering/Biophysics/Physics
  • Nuclear Magnetic Resonance


A selection of recent and significant publications can be viewed below.

Thurber K, Tycko R. Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning. J Magn Reson. 2016 Mar; 264 (264; 2016 Mar):99-106. [Full Text/Abstract]
Potapov A, Yau WM, Ghirlando R, Thurber KR, Tycko R. Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization. J Am Chem Soc. 2015 Jun 12; 137 (25; 2015 Jun 12; 137):8294-307. [Full Text/Abstract]
Gorkovskiy A, Thurber KR, Tycko R, Wickner RB. Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid. Proc Natl Acad Sci U S A. 2014 Oct 13; 111 (43; 111; 2014 Oct 13):E4615-22. [Full Text/Abstract]
Yau WM, Thurber KR, Tycko R. Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR. J Magn Reson. 2014 Jul; 244C (2014 Jul; 244C):98-106. [Full Text/Abstract]
Thurber KR, Tycko R. Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves. J Chem Phys. 2014 May 14; 140 (140; 2014 May 14; 18):184201. [Full Text/Abstract]
Thurber KR, Potapov A, Yau WM, Tycko R. Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K. J Magn Reson. 2013 Jan; 226 (226; 2013 Jan):100-6. [Full Text/Abstract]
Thurber KR, Tycko R. Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings. J Chem Phys. 2012 Aug 28; 137 (2012 Aug 28; 8; 137):084508. [Full Text/Abstract]
Potapov A, Thurber KR, Yau WM, Tycko R. Dynamic nuclear polarization-enhanced ¹H-¹³C double resonance NMR in static samples below 20 K. J Magn Reson. 2012 Aug; 221 (2012 Aug; 221):32-40. [Full Text/Abstract]
Parthasarathy S, Long F, Miller Y, Xiao Y, McElheny D, Thurber K, Ma B, Nussinov R, Ishii Y. Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy. J Am Chem Soc. 2011 Mar 16; 133 (133; 2011 Mar 16; 10):3390-400. [Full Text/Abstract]
Thurber KR, Tycko R. Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization. Phys Chem Chem Phys. 2010 Jun 14; 12 (12; 2010 Jun 14; 22):5779-85. [Full Text/Abstract]
Thurber KR, Yau WM, Tycko R. Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source. J Magn Reson. 2010 Jun; 204 (204; 2010 Jun; 2):303-13. [Full Text/Abstract]
Shewmaker F, McGlinchey RP, Thurber KR, McPhie P, Dyda F, Tycko R, Wickner RB. The functional curli amyloid is not based on in-register parallel beta-sheet structure. J Biol Chem. 2009 Sep 11; 284 (284; 2009 Sep 11; 37):25065-76. [Full Text/Abstract]
Chen B, Thurber KR, Shewmaker F, Wickner RB, Tycko R. Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy. Proc Natl Acad Sci U S A. 2009 Aug 25; 106 (106; 2009 Aug 25; 34):14339-44. [Full Text/Abstract]
McGlinchey RP, Shewmaker F, McPhie P, Monterroso B, Thurber K, Wickner RB. The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis. Proc Natl Acad Sci U S A. 2009 Aug 18; 106 (106; 33; 2009 Aug 18):13731-6. [Full Text/Abstract]
Thurber KR, Tycko R. Measurement of sample temperatures under magic-angle spinning from the chemical shift and spin-lattice relaxation rate of 79Br in KBr powder. J Magn Reson. 2009 Jan; 196 (196; 2009 Jan; 1):84-7. [Full Text/Abstract]
Thurber KR, Tycko R. Biomolecular solid state NMR with magic-angle spinning at 25K. J Magn Reson. 2008 Dec; 195 (2008 Dec; 2; 195):179-86. [Full Text/Abstract]
Thurber KR, Sauer KL, Buess ML, Klug CA, Miller JB. Increasing 14N NQR signal by 1H-14N level crossing with small magnetic fields. J Magn Reson. 2005 Nov; 177 (177; 2005 Nov; 1):118-28. [Full Text/Abstract]
Thurber KR, Harrell LE, Smith DD. 170 nm nuclear magnetic resonance imaging using magnetic resonance force microscopy. J Magn Reson. 2003 Jun; 162 (2003 Jun; 2; 162):336-40. [Full Text/Abstract]
Thurber KR, Hunt AW, Imai T, Chou FC. 17O NMR study of q = 0 spin excitations in a nearly ideal S = 1 / 2 1D Heisenberg antiferromagnet, Sr2CuO3, up to 800 K. Phys Rev Lett. 2001 Dec 10; 87 (87; 24; 2001 Dec 10):247202. [Full Text/Abstract]