The goal is to determine and characterize protein structures that are important for human biology, such as amyloid fibrils, protein folding intermediates, or hormone/receptor complexes.
My research is focused on protein structure determination using solid-state nuclear magnetic resonance (NMR). My current primary project is developing dynamic nuclear polarization (DNP) for solid-state NMR experiments on biomolecules. DNP can increase the NMR signal by 100 times or more, enabling experiments on small samples, or dilute samples, that would not be feasible otherwise. We have developed a custom NMR probe for DNP and magic-angle spinning (MAS) at low temperatures (25 K).
Applying our Research
Need for Further Study
Now that dynamic nuclear polarization (DNP) for solid-state nuclear magnetic resonance (NMR) has been developed, many biomolecules could potentially be studied. In addition, the optimum measurement conditions for biomolecular solid-state NMR with DNP are not well understood.