U.S. Department of Health and Human Services
Kevin O'Connell

 Contact Info

Tel: 301-451-4557
Email: kevino@mail.nih.gov

 Select Experience

  • Senior InvestigatorNIDDK, NIH2010-present
  • InvestigatorNIDDK, NIH2002-2010
  • Assistant ScientistUniversity of Wisconsin1998-2002
  • NRSA FellowUniversity of Wisconsin1995-1998
  • Ph.D.University of Massachusetts Medical School1994
  • B.A.University of New Hampshire1986

 Related Links

  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Peel N, Iyer J, Naik A, Dougherty MP, Decker M, O'Connell KF. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. PLoS Genet. 2017 Jan 19; 13 (13; 2017 Jan 19; 1):e1006543. [Full Text/Abstract]
Miller JG, Liu Y, Williams CW, Smith HE, O'Connell KF. The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans. G3 (Bethesda). 2016 Jan 15; 6 (6; 2016 Jan 15; 3):709-20. [Full Text/Abstract]
O'Connell KF, Golden A. Confocal imaging of the microtubule cytoskeleton in C. elegans embryos and germ cells. Methods Mol Biol. 2014; 1075 (2014; 1075):257-72. [Full Text/Abstract]
Peel N, Dougherty M, Goeres J, Liu Y, O'Connell KF. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci. 2012 Aug 1; 125 (2012 Aug 1; Pt 15; 125):3535-44. [Full Text/Abstract]
Boyd L, Hajjar C, O'Connell K. Time-lapse microscopy of early embryogenesis in Caenorhabditis elegans. J Vis Exp. 2011 Aug 25; (54; 2011 Aug 25). [Full Text/Abstract]
Decker M, Jaensch S, Pozniakovsky A, Zinke A, O'Connell KF, Zachariae W, Myers E, Hyman AA. Limiting amounts of centrosome material set centrosome size in C. elegans embryos. Curr Biol. 2011 Aug 9; 21 (2011 Aug 9; 15; 21):1259-67. [Full Text/Abstract]
Song MH, Liu Y, Anderson DE, Jahng WJ, O'Connell KF. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011 Apr 19; 20 (20; 4; 2011 Apr 19):563-71. [Full Text/Abstract]
Peters N, Perez DE, Song MH, Liu Y, Müller-Reichert T, Caron C, Kemphues KJ, O'Connell KF. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. J Cell Sci. 2010 Mar 1; 123 (2010 Mar 1; 123; Pt 5):795-805. [Full Text/Abstract]
Kumfer KT, Cook SJ, Squirrell JM, Eliceiri KW, Peel N, O'Connell KF, White JG. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo. Mol Biol Cell. 2010 Jan 15; 21 (2010 Jan 15; 2; 21):266-77. [Full Text/Abstract]
Song MH, Aravind L, Müller-Reichert T, O'Connell KF. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell. 2008 Dec; 15 (2008 Dec; 6; 15):901-12. [Full Text/Abstract]
Song MH, Miliaras NB, Peel N, O'Connell KF. Centrioles: some self-assembly required. Curr Opin Cell Biol. 2008 Dec; 20 (20; 2008 Dec; 6):688-93. [Full Text/Abstract]
Kemp CA, Song MH, Addepalli MK, Hunter G, O'Connell K. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Genetics. 2007 May; 176 (2007 May; 176; 1):95-113. [Full Text/Abstract]
Golden A, O'Connell KF. Silence is golden: combining RNAi and live cell imaging to study cell cycle regulatory genes during Caenorhabditis elegans development. Methods. 2007 Feb; 41 (2; 41; 2007 Feb):190-7. [Full Text/Abstract]
Kemp CA, Kopish KR, Zipperlen P, Ahringer J, O'Connell KF. Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell. 2004 Apr; 6 (6; 2004 Apr; 4):511-23. [Full Text/Abstract]
O'Connell KF. The ZYG-1 kinase, a mitotic and meiotic regulator of centriole replication. Oncogene. 2002 Sep 9; 21 (40; 2002 Sep 9; 21):6201-8. [Full Text/Abstract]
O'Connell KF, Caron C, Kopish KR, Hurd DD, Kemphues KJ, Li Y, White JG. The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell. 2001 May 18; 105 (105; 2001 May 18; 4):547-58. [Full Text/Abstract]
O'Connell KF, Maxwell KN, White JG. The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote. Dev Biol. 2000 Jun 1; 222 (222; 2000 Jun 1; 1):55-70. [Full Text/Abstract]
O'Connell KF. The centrosome of the early C. elegans embryo: inheritance, assembly, replication, and developmental roles. Curr Top Dev Biol. 2000; 49 (49; 2000):365-84. [Full Text/Abstract]
O'Connell KF, Leys CM, White JG. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. Genetics. 1998 Jul; 149 (149; 3; 1998 Jul):1303-21. [Full Text/Abstract]