U.S. Department of Health and Human Services
Kevin O'Connell

 Contact Info

Tel: 301-451-4557
Email: kevino@mail.nih.gov

 Select Experience

  • Senior InvestigatorNIDDK, NIH2010-present
  • InvestigatorNIDDK, NIH2002-2010
  • Assistant ScientistUniversity of Wisconsin1998-2002
  • NRSA FellowUniversity of Wisconsin1995-1998
  • Ph.D.University of Massachusetts Medical School1994
  • B.A.University of New Hampshire1986

 Related Links

  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Peel N, Iyer J, Naik A, Dougherty MP, Decker M, O'Connell KF. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. PLoS Genet. 2017 Jan 19; 13 (13; 2017 Jan 19; 1):e1006543. [Full Text/Abstract]
Miller JG, Liu Y, Williams CW, Smith HE, O'Connell KF. The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans. G3 (Bethesda). 2016 Jan 15; 6 (6; 2016 Jan 15; 3):709-20. [Full Text/Abstract]
O'Connell KF, Golden A. Confocal imaging of the microtubule cytoskeleton in C. elegans embryos and germ cells. Methods Mol Biol. 2014; 1075 (2014; 1075):257-72. [Full Text/Abstract]
Peel N, Dougherty M, Goeres J, Liu Y, O'Connell KF. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci. 2012 Aug 1; 125 (2012 Aug 1; Pt 15; 125):3535-44. [Full Text/Abstract]
Boyd L, Hajjar C, O'Connell K. Time-lapse microscopy of early embryogenesis in Caenorhabditis elegans. J Vis Exp. 2011 Aug 25; (54; 2011 Aug 25). [Full Text/Abstract]
Song MH, Liu Y, Anderson DE, Jahng WJ, O'Connell KF. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011 Apr 19; 20 (20; 4; 2011 Apr 19):563-71. [Full Text/Abstract]
Peters N, Perez DE, Song MH, Liu Y, Müller-Reichert T, Caron C, Kemphues KJ, O'Connell KF. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. J Cell Sci. 2010 Mar 1; 123 (2010 Mar 1; 123; Pt 5):795-805. [Full Text/Abstract]
Kumfer KT, Cook SJ, Squirrell JM, Eliceiri KW, Peel N, O'Connell KF, White JG. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo. Mol Biol Cell. 2010 Jan 15; 21 (2010 Jan 15; 2; 21):266-77. [Full Text/Abstract]
Song MH, Aravind L, Müller-Reichert T, O'Connell KF. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell. 2008 Dec; 15 (2008 Dec; 6; 15):901-12. [Full Text/Abstract]
Song MH, Miliaras NB, Peel N, O'Connell KF. Centrioles: some self-assembly required. Curr Opin Cell Biol. 2008 Dec; 20 (20; 2008 Dec; 6):688-93. [Full Text/Abstract]
Kemp CA, Song MH, Addepalli MK, Hunter G, O'Connell K. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Genetics. 2007 May; 176 (2007 May; 176; 1):95-113. [Full Text/Abstract]
Golden A, O'Connell KF. Silence is golden: combining RNAi and live cell imaging to study cell cycle regulatory genes during Caenorhabditis elegans development. Methods. 2007 Feb; 41 (2; 41; 2007 Feb):190-7. [Full Text/Abstract]
Kemp CA, Kopish KR, Zipperlen P, Ahringer J, O'Connell KF. Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell. 2004 Apr; 6 (6; 2004 Apr; 4):511-23. [Full Text/Abstract]
O'Connell KF. The ZYG-1 kinase, a mitotic and meiotic regulator of centriole replication. Oncogene. 2002 Sep 9; 21 (40; 2002 Sep 9; 21):6201-8. [Full Text/Abstract]
O'Connell KF, Caron C, Kopish KR, Hurd DD, Kemphues KJ, Li Y, White JG. The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell. 2001 May 18; 105 (105; 2001 May 18; 4):547-58. [Full Text/Abstract]
O'Connell KF, Maxwell KN, White JG. The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote. Dev Biol. 2000 Jun 1; 222 (222; 2000 Jun 1; 1):55-70. [Full Text/Abstract]
O'Connell KF. The centrosome of the early C. elegans embryo: inheritance, assembly, replication, and developmental roles. Curr Top Dev Biol. 2000; 49 (49; 2000):365-84. [Full Text/Abstract]
O'Connell KF, Leys CM, White JG. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. Genetics. 1998 Jul; 149 (149; 3; 1998 Jul):1303-21. [Full Text/Abstract]