U.S. Department of Health and Human Services
Kong Chen

 Contact Info

Tel: 301-451-1636
Email: chenkong@niddk.nih.gov

 Select Experience

  • Assistant Professor of Medicine, Biomedical Engineering, and SurgeryVanderbilt University1997-2006
  • M.S.Vanderbilt University2002
  • Ph.D.Vanderbilt University1997

 Related Links

  • Biomedical Engineering/Biophysics/Physics
  • Clinical Research
  • Epidemiology/Population Sciences
  • Physiology and Energy Metabolism
  • Social and Behavioral Sciences


A selection of recent and significant publications can be viewed below.

Brychta RJ, Arnardottir NY, Johannsson E, Wright EC, Eiriksdottir G, Gudnason V, Marinac CR, Davis M, Koster A, Caserotti P, Sveinsson T, Harris T, Chen KY. Influence of Day Length and Physical Activity on Sleep Patterns in Older Icelandic Men and Women. J Clin Sleep Med. 2015 Sep 14; 12 (2015 Sep 14; 2; 12):203-213. [Full Text/Abstract]
Arnardottir NY, Koster A, Domelen DR, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Sigurdsson S, Johannsson E, Chen KY, Gudnason V, Harris TB, Launer LJ, Sveinsson T. Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Behav Brain Res. 2015 Sep 10; 296 (296; 2015 Sep 10):118-24. [Full Text/Abstract]
Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV 3rd, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metab. 2015 Sep 1; 22 (3; 22; 2015 Sep 1):427-36. [Full Text/Abstract]
Belcher BR, Berrigan D, Papachristopoulou A, Brady SM, Bernstein SB, Brychta RJ, Hattenbach JD, Tigner IL Jr, Courville AB, Drinkard BE, Smith KP, Rosing DR, Wolters PL, Chen KY, Yanovski JA. Effects of Interrupting Children's Sedentary Behaviors With Activity on Metabolic Function: A Randomized Trial. J Clin Endocrinol Metab. 2015 Aug 27; 100 (100; 10; 2015 Aug 27):3735-3743. [Full Text/Abstract]
Sasai H, Brychta RJ, Wood RP, Rothney MP, Zhao X, Skarulis MC, Chen KY. Does Visceral Fat Estimated by Dual-Energy X-ray Absorptiometry Independently Predict Cardiometabolic Risks in Adults?. J Diabetes Sci Technol. 2015 Mar 23; 9 (2015 Mar 23; 4; 9):917-24. [Full Text/Abstract]
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC. RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals. J Clin Endocrinol Metab. 2015 Feb 12; 100 (100; 2015 Feb 12; 4):1639-1645. [Full Text/Abstract]
Martin KR, Koster A, Murphy RA, Van Domelen DR, Hung MY, Brychta RJ, Chen KY, Harris TB. Changes in Daily Activity Patterns with Age in U.S. Men and Women: National Health and Nutrition Examination Survey 2003-04 and 2005-06. J Am Geriatr Soc. 2014 Jul; 62 (7; 62; 2014 Jul):1263-71. [Full Text/Abstract]
Troiano RP, McClain JJ, Brychta RJ, Chen KY. Evolution of accelerometer methods for physical activity research. Br J Sports Med. 2014 Jul; (2014 Jul). [Full Text/Abstract]
Lee P, Smith S, Linderman J, Courville AB, Brychta RJ, Dieckmann W, Werner CD, Chen KY, Celi FS. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes. 2014 Jun 22; 63 (2014 Jun 22; 63; 11):3686-98. [Full Text/Abstract]
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 2014 Feb 4; 19 (19; 2; 2014 Feb 4):302-9. [Full Text/Abstract]
Tracy DJ, Xu Z, Choi L, Acra S, Chen KY, Buchowski MS. Separating bedtime rest from activity using waist or wrist-worn accelerometers in youth. PLoS One. 2014; 9 (2014; 4; 9):e92512. [Full Text/Abstract]
Carnie A, Lin J, Aicher B, Leon B, Courville AB, Sebring NG, de Jesus J, Dellavalle DM, Fitzpatrick BD, Zalos G, Powell-Wiley TM, Chen KY, Cannon RO 3rd. Randomized trial of nutrition education added to internet-based information and exercise at the work place for weight loss in a racially diverse population of overweight women. Nutr Diabetes. 2013 Dec 23; 3 (2013 Dec 23; 3):e98. [Full Text/Abstract]
Lee P, Linderman J, Smith S, Brychta RJ, Perron R, Idelson C, Werner CD, Chen KY, Celi FS. Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?. Osteoporos Int. 2013 Dec; 24 (2013 Dec; 12; 24):3053-7. [Full Text/Abstract]
Leon B, Jenkins S, Pepin K, Chaudhry H, Smith K, Zalos G, Miller BV 3rd, Chen KY, Remaley AT, Waclawiw MA, Sumner AE, Cannon RO 3rd. Insulin and extremity muscle mass in overweight and obese women. Int J Obes (Lond). 2013 Dec; 37 (2013 Dec; 37; 12):1560-4. [Full Text/Abstract]
Muniyappa R, Warren MA, Zhao X, Aney SC, Courville AB, Chen KY, Brychta RJ, Germain-Lee EL, Weinstein LS, Skarulis MC. Reduced Insulin Sensitivity in Adults with Pseudohypoparathyroidism Type 1a. J Clin Endocrinol Metab. 2013 Nov; 98 (98; 2013 Nov; 11):E1796-801. [Full Text/Abstract]
Muniyappa R, Sable S, Ouwerkerk R, Mari A, Gharib AM, Walter M, Courville A, Hall G, Chen KY, Volkow ND, Kunos G, Huestis MA, Skarulis MC. Metabolic effects of chronic cannabis smoking. Diabetes Care. 2013 Aug; 36 (8; 2013 Aug; 36):2415-22. [Full Text/Abstract]
Chen KY, Brychta RJ, Linderman JD, Smith S, Courville A, Dieckmann W, Herscovitch P, Millo CM, Remaley A, Lee P, Celi FS. Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature. J Clin Endocrinol Metab. 2013 Jul; 98 (98; 7; 2013 Jul):E1218-23. [Full Text/Abstract]
Psota T, Chen KY. Measuring energy expenditure in clinical populations: rewards and challenges. Eur J Clin Nutr. 2013 May; 67 (2013 May; 67; 5):436-42. [Full Text/Abstract]
Lee P, Brychta RJ, Collins MT, Linderman J, Smith S, Herscovitch P, Millo C, Chen KY, Celi FS. Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women. Osteoporos Int. 2013 Apr; 24 (4; 24; 2013 Apr):1513-8. [Full Text/Abstract]
Arnardottir NY, Koster A, Van Domelen DR, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Launer LJ, Gudnason V, Johannsson E, Harris TB, Chen KY, Sveinsson T. Objective measurements of daily physical activity patterns and sedentary behaviour in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Age Ageing. 2013 Mar; 42 (2013 Mar; 2; 42):222-9. [Full Text/Abstract]
Chen KY, Janz KF, Zhu W, Brychta RJ. Redefining the roles of sensors in objective physical activity monitoring. Med Sci Sports Exerc. 2012 Jan; 44 (1 Suppl 1; 44; 2012 Jan):S13-23. [Full Text/Abstract]
Celi FS, Brychta RJ, Linderman JD, Butler PW, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Csako G, Remaley A, Pacak K, Chen KY. Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults. Eur J Endocrinol. 2010 Dec; 163 (6; 2010 Dec; 163):863-72. [Full Text/Abstract]
Rothney MP, Brychta RJ, Meade NN, Chen KY, Buchowski MS. Validation of the ActiGraph two-regression model for predicting energy expenditure. Med Sci Sports Exerc. 2010 Sep; 42 (42; 2010 Sep; 9):1785-92. [Full Text/Abstract]
Tamboli RA, Hossain HA, Marks PA, Eckhauser AW, Rathmacher JA, Phillips SE, Buchowski MS, Chen KY, Abumrad NN. Body composition and energy metabolism following Roux-en-Y gastric bypass surgery. Obesity (Silver Spring). 2010 Sep; 18 (2010 Sep; 9; 18):1718-24. [Full Text/Abstract]
Brychta R, Wohlers E, Moon J, Chen K. Energy expenditure: measurement of human metabolism. IEEE Eng Med Biol Mag. 2010 Jan-Feb; 29 (29; 1; 2010 Jan-Feb):42-7. [Full Text/Abstract]
Rothney MP, Brychta RJ, Schaefer EV, Chen KY, Skarulis MC. Body composition measured by dual-energy X-ray absorptiometry half-body scans in obese adults. Obesity (Silver Spring). 2009 Jun; 17 (6; 17; 2009 Jun):1281-6. [Full Text/Abstract]
Brychta RJ, Rothney MP, Skarulis MC, Chen KY. Optimizing energy expenditure detection in human metabolic chambers. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009 (2009):6864-8. [Full Text/Abstract]
Rothney MP, Schaefer EV, Neumann MM, Choi L, Chen KY. Validity of physical activity intensity predictions by ActiGraph, Actical, and RT3 accelerometers. Obesity (Silver Spring). 2008 Aug; 16 (8; 16; 2008 Aug):1946-52. [Full Text/Abstract]
Matthews CE, Chen KY, Freedson PS, Buchowski MS, Beech BM, Pate RR, Troiano RP. Amount of time spent in sedentary behaviors in the United States, 2003-2004. Am J Epidemiol. 2008 Apr 1; 167 (7; 2008 Apr 1; 167):875-81. [Full Text/Abstract]
Rothney MP, Neumann M, Béziat A, Chen KY. An artificial neural network model of energy expenditure using nonintegrated acceleration signals. J Appl Physiol (1985). 2007 Oct; 103 (2007 Oct; 4; 103):1419-27. [Full Text/Abstract]
Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension. 2007 Jan; 49 (49; 2007 Jan; 1):27-33. [Full Text/Abstract]
Chen KY, Bassett DR Jr. The technology of accelerometry-based activity monitors: current and future. Med Sci Sports Exerc. 2005 Nov; 37 (11 Suppl; 2005 Nov; 37):S490-500. [Full Text/Abstract]