U.S. Department of Health and Human Services
Kristin Tarbell
 

 Contact Info

 
Tel: 301-451-9360
Email: tarbellk@mail.nih.gov
 

 Select Experience

 
  • Postdoctoral Fellow and Research AssociateRockefeller University2002-2007
  • Ph.D.Stanford University2002
  • B.A.Cornell University1995
 

 Related Links

 

Kristin Tarbell, Ph.D.

Acting Section Chief, Immune Tolerance SectionDiabetes, Endocrinology, and Obesity Branch
Specialties
  • Immunology

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Decalf J, Tarbell KV, Casrouge A, Price JD, Linder G, Mottez E, Sultanik P, Mallet V, Pol S, Duffy D, Albert ML. Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies. EMBO Mol Med. 2016 Apr 9; 8 (6; 8; 2016 Apr 9):679-83. [Full Text/Abstract]
Rahman MJ, Rahir G, Dong MB, Zhao Y, Rodrigues KB, Hotta-Iwamura C, Chen Y, Guerrero A, Tarbell KV. Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1. J Immunol. 2016 Jan 29; 196 (196; 2016 Jan 29; 5):2031-40. [Full Text/Abstract]
Hotta-Iwamura C, Tarbell KV. Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment. J Leukoc Biol. 2016 Jan 20; 100 (100; 2016 Jan 20; 1):65-80. [Full Text/Abstract]
Dong MB, Rahman MJ, Tarbell KV. Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation. J Immunol Methods. 2015 Sep 4; 432 (432; 2015 Sep 4):4-12. [Full Text/Abstract]
Zhao Y, Tarbell KV. Comment on Sofi et al. pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence. Diabetes 2014;63:632-644. Diabetes. 2015 Aug; 64 (8; 64; 2015 Aug):e19. [Full Text/Abstract]
Tarbell KV, Rane SG. Saving β cell function in the NIK of time. J Exp Med. 2015 Jul 27; 212 (2015 Jul 27; 212; 8):1140-1. [Full Text/Abstract]
Price JD, Hotta-Iwamura C, Zhao Y, Beauchamp NM, Tarbell KV. DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes. Diabetes. 2015 Jun 12; 64 (64; 2015 Jun 12; 10):3521-31. [Full Text/Abstract]
Price JD, Tarbell KV. The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases. Front Immunol. 2015 Jun 15; 6 (6; 2015 Jun 15):288. [Full Text/Abstract]
Guerrero AD, Dong MB, Zhao Y, Lau-Kilby A, Tarbell KV. Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors. Immunology. 2014 Jun 23; 143 (2014 Jun 23; 4; 143):640-50. [Full Text/Abstract]
Price JD, Beauchamp NM, Rahir G, Zhao Y, Rieger CC, Lau-Kilby AW, Tarbell KV. CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L. J Leukoc Biol. 2014 Feb; 95 (95; 2; 2014 Feb):325-36. [Full Text/Abstract]
Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, Dilorenzo TP. DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1. Int Immunol. 2013 Nov; 25 (25; 2013 Nov; 11):651-60. [Full Text/Abstract]
Price JD, Linder G, Li WP, Zimmermann B, Rother KI, Malek R, Alattar M, Tarbell KV. Effects of Short-Term Sitagliptin Treatment on Immune Parameters in Healthy Individuals, A Randomized Placebo-Controlled Study. Clin Exp Immunol. 2013 Oct; 174 (2013 Oct; 174; 1):120-8. [Full Text/Abstract]
Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-Expressing Cells Are a Distinct Bone Marrow-Derived Population that Induce Functional Inactivation of CD4(+) T Cells. Immunity. 2013 Sep 19; 39 (39; 3; 2013 Sep 19):560-72. [Full Text/Abstract]
Hübner MP, Shi Y, Torrero MN, Mueller E, Larson D, Soloviova K, Gondorf F, Hoerauf A, Killoran KE, Stocker JT, Davies SJ, Tarbell KV, Mitre E. Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β. J Immunol. 2012 Jan 15; 188 (188; 2012 Jan 15; 2):559-68. [Full Text/Abstract]
Lau-Kilby AW, Kretz CC, Pechhold S, Price JD, Dorta S, Ramos H, Trinchieri G, Tarbell KV. Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2011 Feb 8; 108 (2011 Feb 8; 108; 6):2408-13. [Full Text/Abstract]
Belkaid Y, Tarbell KV. Arming Treg cells at the inflammatory site. Immunity. 2009 Mar 20; 30 (2009 Mar 20; 30; 3):322-3. [Full Text/Abstract]
Belkaid Y, Tarbell K. Regulatory T cells in the control of host-microorganism interactions (*). Annu Rev Immunol. 2009; 27 (2009; 27):551-89. [Full Text/Abstract]
Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP. Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proc Natl Acad Sci U S A. 2008 Apr 29; 105 (105; 17; 2008 Apr 29):6374-9. [Full Text/Abstract]
Luo X, Tarbell KV, Yang H, Pothoven K, Bailey SL, Ding R, Steinman RM, Suthanthiran M. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2007 Feb 20; 104 (104; 8; 2007 Feb 20):2821-6. [Full Text/Abstract]
Tarbell KV, Petit L, Zuo X, Toy P, Luo X, Mqadmi A, Yang H, Suthanthiran M, Mojsov S, Steinman RM. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med. 2007 Jan 22; 204 (204; 2007 Jan 22; 1):191-201. [Full Text/Abstract]
Yamazaki S, Inaba K, Tarbell KV, Steinman RM. Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity. Immunol Rev. 2006 Aug; 212 (2006 Aug; 212):314-29. [Full Text/Abstract]
Tarbell KV, Yamazaki S, Steinman RM. The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity. Semin Immunol. 2006 Apr; 18 (2; 2006 Apr; 18):93-102. [Full Text/Abstract]
Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol. 2005 Sep 1; 175 (175; 5; 2005 Sep 1):3053-9. [Full Text/Abstract]
Kim SK, Tarbell KV, Sanna M, Vadeboncoeur M, Warganich T, Lee M, Davis M, McDevitt HO. Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells. Proc Natl Acad Sci U S A. 2004 Sep 28; 101 (101; 39; 2004 Sep 28):14204-9. [Full Text/Abstract]
Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004 Jun 7; 199 (2004 Jun 7; 199; 11):1467-77. [Full Text/Abstract]
Yamazaki S, Iyoda T, Tarbell K, Olson K, Velinzon K, Inaba K, Steinman RM. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med. 2003 Jul 21; 198 (2003 Jul 21; 2; 198):235-47. [Full Text/Abstract]
Tarbell KV, Lee M, Ranheim E, Chao CC, Sanna M, Kim SK, Dickie P, Teyton L, Davis M, McDevitt H. CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer. J Exp Med. 2002 Aug 19; 196 (196; 4; 2002 Aug 19):481-92. [Full Text/Abstract]