U.S. Department of Health and Human Services
Leslie Baier

 Contact Info

Tel: 602-440-6589
Email: lbaier@phx.niddk.nih.gov

 Select Experience

  • Ph.D.University of Michigan1990
  • B.A.Lawrence University1982

 Related Links


    • Genetics/Genomics


    A selection of recent and significant publications can be viewed below.

    Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C. Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure. Diabetologia. 2014 Jul; 57 (7; 2014 Jul; 57):1382-90. [Full Text/Abstract]
    Del Rosario MC, Ossowski V, Knowler WC, Bogardus C, Baier LJ, Hanson RL. Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: An analysis of genome-wide DNA methylation. Metabolism. 2014 May; 63 (2014 May; 63; 5):654-60. [Full Text/Abstract]
    Huang K, Nair AK, Muller YL, Piaggi P, Bian L, Del Rosario M, Knowler WC, Kobes S, Hanson RL, Bogardus C, Baier LJ. Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes. Obesity (Silver Spring). 2014 Apr; 22 (4; 2014 Apr; 22):984-8. [Full Text/Abstract]
    Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1 (2014 Feb; 22 Suppl 1):S1-S17. [Full Text/Abstract]
    Hanson RL, Muller YL, Kobes S, Guo T, Bian L, Ossowski V, Wiedrich K, Sutherland J, Wiedrich C, Mahkee D, Huang K, Abdussamad M, Traurig M, Weil EJ, Nelson RG, Bennett PH, Knowler WC, Bogardus C, Baier LJ. A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes. Diabetes. 2014 Jan; 63 (2014 Jan; 63; 1):369-76. [Full Text/Abstract]
    Muller YL, Hanson RL, Knowler WC, Fleming J, Goswami J, Huang K, Traurig M, Sutherland J, Wiedrich C, Wiedrich K, Mahkee D, Ossowski V, Kobes S, Bogardus C, Baier LJ. Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes. Hum Genet. 2013 Jun; 132 (6; 132; 2013 Jun):697-707. [Full Text/Abstract]
    Traurig MT, Perez JM, Ma L, Bian L, Kobes S, Hanson RL, Knowler WC, Krakoff JA, Bogardus C, Baier LJ. Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians. Obesity (Silver Spring). 2012 Dec; 20 (2012 Dec; 20; 12):2426-30. [Full Text/Abstract]
    Thearle MS, Muller YL, Hanson RL, Mullins M, Abdussamad M, Tran J, Knowler WC, Bogardus C, Krakoff J, Baier LJ. Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians. Diabetes. 2012 Jan; 61 (1; 2012 Jan; 61):250-7. [Full Text/Abstract]
    Dong Y, Guo T, Traurig M, Mason CC, Kobes S, Perez J, Knowler WC, Bogardus C, Hanson RL, Baier LJ. SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. Mol Genet Metab. 2011 Dec; 104 (104; 4; 2011 Dec):661-5. [Full Text/Abstract]
    Muller YL, Hanson RL, Bian L, Mack J, Shi X, Pakyz R, Shuldiner AR, Knowler WC, Bogardus C, Baier LJ. Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish. Diabetes. 2010 Aug; 59 (8; 59; 2010 Aug):2080-5. [Full Text/Abstract]
    Acuña-Alonzo V, Flores-Dorantes T, Kruit JK, Villarreal-Molina T, Arellano-Campos O, Hünemeier T, Moreno-Estrada A, Ortiz-López MG, Villamil-Ramírez H, León-Mimila P, Villalobos-Comparan M, Jacobo-Albavera L, Ramírez-Jiménez S, Sikora M, Zhang LH, Pape TD, Granados-Silvestre Mde A, Montufar-Robles I, Tito-Alvarez AM, Zurita-Salinas C, Bustos-Arriaga J, Cedillo-Barrón L, Gómez-Trejo C, Barquera-Lozano R, Vieira-Filho JP, Granados J, Romero-Hidalgo S, Huertas-Vázquez A, González-Martín A, Gorostiza A, Bonatto SL, Rodríguez-Cruz M, Wang L, Tusié-Luna T, Aguilar-Salinas CA, Lisker R, Moises RS, Menjivar M, Salzano FM, Knowler WC, Bortolini MC, Hayden MR, Baier LJ, Canizales-Quinteros S. A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet. 2010 Jul 15; 19 (14; 19; 2010 Jul 15):2877-85. [Full Text/Abstract]
    Bian L, Hanson RL, Ossowski V, Wiedrich K, Mason CC, Traurig M, Muller YL, Kobes S, Knowler WC, Baier LJ, Bogardus C. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. Diabetes. 2010 May; 59 (2010 May; 59; 5):1276-82. [Full Text/Abstract]
    Traurig M, Mack J, Hanson RL, Ghoussaini M, Meyre D, Knowler WC, Kobes S, Froguel P, Bogardus C, Baier LJ. Common variation in SIM1 is reproducibly associated with BMI in Pima Indians. Diabetes. 2009 Jul; 58 (7; 58; 2009 Jul):1682-9. [Full Text/Abstract]
    Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC, Bogardus C, Baier LJ. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes. 2009 Feb; 58 (2009 Feb; 2; 58):478-88. [Full Text/Abstract]
    Hanson RL, Bogardus C, Duggan D, Kobes S, Knowlton M, Infante AM, Marovich L, Benitez D, Baier LJ, Knowler WC. A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes. 2007 Dec; 56 (56; 2007 Dec; 12):3045-52. [Full Text/Abstract]
    Baier LJ, Hanson RL. Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle. Diabetes. 2004 May; 53 (5; 53; 2004 May):1181-6. [Full Text/Abstract]