U.S. Department of Health and Human Services
 

 Contact Info

 
Tel: 301-594-3479
Email: ln112e@nih.gov
 

 Select Experience

 
  • Staff ScientistNIDDK, NIH2004–Present
  • Research Assistant ProfessorDepartment of Human Genetics, Mount Sinai School of Medicine1997–2004
  • Ph.D.State University of New York at Stony Brook1991
 

 Related Links

 
Specialties
  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Molecular Biology/Biochemistry

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Russell T, Ng L, Nathan E, Debenham E. Supplementation of standard pre-oxygenation with nasal prong oxygen or machine oxygen flush during a simulated leak scenario. Anaesthesia. 2014 Jun 14; 69 (69; 2014 Jun 14; 10):1133-7. [Full Text/Abstract]
Pun JC, Chan JY, Chun BK, Ng KW, Tsui SY, Wan TM, Lo O, Poon JT, Ng L, Pang R. Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients. Mol Clin Oncol. 2014 Sep; 2 (2; 5; 2014 Sep):817-820. [Full Text/Abstract]
Mantis I, Stack DM, Ng L, Serbin LA, Schwartzman AE. Mutual touch during mother-infant face-to-face still-face interactions: influences of interaction period and infant birth status. Infant Behav Dev. 2014 Aug; 37 (2014 Aug; 37; 3):258-267. [Full Text/Abstract]
Shelley DA, Sih BL, Ng LJ. An integrated physiology model to study regional lung damage effects and the physiologic response. Theor Biol Med Model. 11 (11; 1):32. [Full Text/Abstract]
Jauch SY, Coles LG, Ng LV, Miles AW, Gill HS. Low torque levels can initiate a removal of the passivation layer and cause fretting in modular hip stems. Med Eng Phys. [Full Text/Abstract]
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR. A High-Resolution Spatiotemporal Atlas of Gene Expression of the Developing Mouse Brain. Neuron. 2014 Jul 16; 83 (83; 2; 2014 Jul 16):309-323. [Full Text/Abstract]
Choudhury Y, Wei X, Chu YH, Ng LG, Tan HS, Koh V, Thike AA, Poon E, Ng QS, Toh CK, Kanesvaran R, Tan PH, Tan MH. A Multigene Assay Identifying Distinct Prognostic Subtypes of Clear Cell Renal Cell Carcinoma with Differential Response to Tyrosine Kinase Inhibition. Eur Urol. [Full Text/Abstract]
Volman V, Ng LJ. Primary paranode demyelination modulates slowly developing axonal depolarization in a model of axonal injury. J Comput Neurosci. [Full Text/Abstract]
Howe A, Campbell A, Ng L, Hall T, Hopper D. Effects of two different knee tape procedures on lower-limb kinematics and kinetics in recreational runners. Scand J Med Sci Sports. 2014 Jul 2; 25 (25; 2014 Jul 2; 4):517-24. [Full Text/Abstract]
Hedditch EL, Gao B, Russell AJ, Lu Y, Emmanuel C, Beesley J, Johnatty SE, Chen X, Harnett P, George J, Australian Ovarian Cancer Study Group, Williams RT, Flemming C, Lambrechts D, Despierre E, Lambrechts S, Vergote I, Karlan B, Lester J, Orsulic S, Walsh C, Fasching P, Beckmann MW, Ekici AB, Hein A, Matsuo K, Hosono S, Nakanishi T, Yatabe Y, Pejovic T, Bean Y, Heitz F, Harter P, du Bois A, Schwaab I, Hogdall E, Kjaer SK, Jensen A, Hogdall C, Lundvall L, Engelholm SA, Brown B, Flanagan J, Metcalf MD, Siddiqui N, Sellers T, Fridley B, Cunningham J, Schildkraut J, Iversen E, Weber RP, Berchuck A, Goode E, Bowtell DD, Chenevix-Trench G, deFazio A, Norris MD, MacGregor S, Haber M, Henderson MJ. ABCA transporter gene expression and poor outcome in epithelial ovarian cancer. J Natl Cancer Inst. 106 (106; 7). [Full Text/Abstract]
Ng L, Wang J, Altaweel L, Athar MK. Neurologic aspects of cardiac emergencies. Crit Care Clin. 2014 Jul; 30 (30; 2014 Jul; 3):557-84. [Full Text/Abstract]
Betancourt TS, Ng LC, Kirk CM, Munyanah M, Mushashi C, Ingabire C, Teta S, Beardslee WR, Brennan RT, Zahn I, Stulac S, Cyamatare FR, Sezibera V. Family-based prevention of mental health problems in children affected by HIV and AIDS: an open trial. AIDS. 28 Suppl 3 (28 Suppl 3):S359-S368. [Full Text/Abstract]
Kasai S, Komagata O, Itokawa K, Shono T, Ng LC, Kobayashi M, Tomita T. Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insensitivity, penetration, and metabolism. PLoS Negl Trop Dis. 8 (6; 8):e2948. [Full Text/Abstract]
Oon LL, Ng LC. Chikungunya in Singapore - the Battle Continues. Ann Acad Med Singapore. 43 (6; 43):325-327. [Full Text/Abstract]
Sandhu JK, Auluck J, Ng LL, Jones DJ. Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research. Biomed Chromatogr. 28 (28; 6):913-7. [Full Text/Abstract]
Huy TC, Quinn PA, Sandhu JK, Voors AA, Parry H, Lang CC, Jones DJ, Ng LL. 52 Discovering New Biomarkers for Predicting Treatment Response in Heart Failure Using Plasma Proteomics. Heart. 100 (100; Suppl 3):A30. [Full Text/Abstract]
Narayan H, Ng L, Squire I, Mohammed N, Quinn P. 51 Plasma MMP-3: A Novel Indicator of Left Ventricle Remodelling and Adverse Outcomes in Patients with Acute Heart Failure. Heart. 2014 Jun; 100 (100; Suppl 3; 2014 Jun):A29-A30. [Full Text/Abstract]
Kumar P, Pok KY, Tan LK, Angela C, Leo YS, Ng LC. Development and Evaluation of Baculovirus-expressed Chikungunya Virus E1 Envelope Proteins for Serodiagnosis of Chikungunya Infection. J Virol Methods. [Full Text/Abstract]
Low JG, Sung C, Wijaya L, Wei Y, Rathore AP, Watanabe S, Tan BH, Toh L, Chua LT, Hou Y, Chow A, Howe S, Chan WK, Tan KH, Chung JS, Cherng BP, Lye DC, Tambayah PA, Ng LC, Connolly J, Hibberd ML, Leo YS, Cheung YB, Ooi EE, Vasudevan SG. Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet Infect Dis. 14 (14; 8):706-15. [Full Text/Abstract]
Tse HN, Raiteri L, Wong KY, Ng LY, Yee KS, Tseng CZ. Benefits of high dose N-acetylcysteine to exacerbation-prone COPD patients. Chest. [Full Text/Abstract]
Gao B, Russell A, Beesley J, Chen XQ, Healey S, Henderson M, Wong M, Emmanuel C, Galletta L, Johnatty SE, Bowtell D, Australian Ovarian Cancer Study Group, Haber M, Norris M, Harnett P, Chenevix-Trench G, Balleine RL, Defazio A. Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer. Sci Rep. 4 (4):4669. [Full Text/Abstract]
Siow MY, Ng LP, Chong VK, Jamaludin M, Abraham MT, Abdul Rahman ZA, Kallarakkal TG, Yang YH, Cheong SC, Zain RB. Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma. Oral Dis. 20 (20; 4):345-51. [Full Text/Abstract]
Xu HY, Fu X, Lee LK, Ma S, Goh KT, Wong J, Habibullah MS, Lee GK, Lim TK, Tambyah PA, Lim CL, Ng LC. Statistical Modeling Reveals the Effect of Absolute Humidity on Dengue in Singapore. PLoS Negl Trop Dis. 8 (8; 5):e2805. [Full Text/Abstract]
Ng LM, Melcher K, Teh BT, Xu HE. Abscisic acid perception and signaling: structural mechanisms and applications. Acta Pharmacol Sin. 35 (35; 5):567-584. [Full Text/Abstract]
Kuhmann C, Li C, Kloor M, Salou M, Weigel C, Schmidt CR, Ng LW, Tsui WW, Leung SY, Yuen ST, Becker N, Weichenhan D, Plass C, Schmezer P, Chan TL, Popanda O. Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer. Hum Mol Genet. 23 (8; 23):2043-54. [Full Text/Abstract]
Pua U, Quek LH, Ng LC. Central Stentoplasty: Technique for Unipedicular Single Midline Vertebral Body Stent Implantation. Cardiovasc Intervent Radiol. [Full Text/Abstract]
Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Ebbert A, Riley ZL, Royall JJ, Aiona K, Arnold JM, Bennet C, Bertagnolli D, Brouner K, Butler S, Caldejon S, Carey A, Cuhaciyan C, Dalley RA, Dee N, Dolbeare TA, Facer BA, Feng D, Fliss TP, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Howard RE, Jochim JM, Kuan CL, Lau C, Lee CK, Lee F, Lemon TA, Lesnar P, McMurray B, Mastan N, Mosqueda N, Naluai-Cecchini T, Ngo NK, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry SE, Stevens A, Pletikos M, Reding M, Roll K, Sandman D, Sarreal M, Shapouri S, Shapovalova NV, Shen EH, Sjoquist N, Slaughterbeck CR, Smith M, Sodt AJ, Williams D, Zöllei L, Fischl B, Gerstein MB, Geschwind DH, Glass IA, Hawrylycz MJ, Hevner RF, Huang H, Jones AR, Knowles JA, Levitt P, Phillips JW, Sestan N, Wohnoutka P, Dang C, Bernard A, Hohmann JG, Lein ES. Transcriptional landscape of the prenatal human brain. Nature. 2014 Apr 10; 508 (7495; 2014 Apr 10; 508):199-206. [Full Text/Abstract]
Oh SW, Harris JA, Ng L, Winslow B, Cain N, Mihalas S, Wang Q, Lau C, Kuan L, Henry AM, Mortrud MT, Ouellette B, Nguyen TN, Sorensen SA, Slaughterbeck CR, Wakeman W, Li Y, Feng D, Ho A, Nicholas E, Hirokawa KE, Bohn P, Joines KM, Peng H, Hawrylycz MJ, Phillips JW, Hohmann JG, Wohnoutka P, Gerfen CR, Koch C, Bernard A, Dang C, Jones AR, Zeng H. A mesoscale connectome of the mouse brain. Nature. 2014 Apr 10; 508 (7495; 2014 Apr 10; 508):207-14. [Full Text/Abstract]
Grange P, Bohland JW, Okaty BW, Sugino K, Bokil H, Nelson SB, Ng L, Hawrylycz M, Mitra PP. Cell-type-based model explaining coexpression patterns of genes in the brain. Proc Natl Acad Sci U S A. 2014 Apr 8; 111 (14; 111; 2014 Apr 8):5397-402. [Full Text/Abstract]
Tan TY, Ng LS, Sim DM, Cheng Y, Min MO. Evaluation of bacterial recovery and viability from three different swab transport systems. Pathology. 2014 Apr; 46 (46; 3; 2014 Apr):230-3. [Full Text/Abstract]
Wang XN, McGovern N, Gunawan M, Richardson C, Windebank M, Siah TW, Lim HY, Fink K, Li JL, Ng LG, Ginhoux F, Angeli V, Collin M, Haniffa M. A three-dimensional atlas of human dermal leukocytes, lymphatics, and blood vessels. J Invest Dermatol. 134 (134; 4):965-74. [Full Text/Abstract]
Ng LT, Lin LT, Chen CL, Chen HW, Wu SJ, Lin CC. Anti-melanogenic effects of δ-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells. Phytomedicine. [Full Text/Abstract]
Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR, Halliwell B. The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease. Free Radic Biol Med. 71C (71C):390-401. [Full Text/Abstract]
Peck Y, Ng LY, Goh JY, Gao C, Wang DA. A Three-Dimensionally Engineered Biomimetic Cartilaginous Tissue Model for Osteoarthritic Drug Evaluation. Mol Pharm. [Full Text/Abstract]
Bakocevic N, Claser C, Yoshikawa S, Jones LA, Chew S, Goh CC, Malleret B, Larbi A, Ginhoux F, de Lafaille MC, Karasuyama H, Renia L, Ng LG. CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections. Eur J Immunol. [Full Text/Abstract]
Chong SZ, Tan KW, Wong FH, Chua YL, Tang Y, Ng LG, Angeli V, Kemeny DM. CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells. J Invest Dermatol. 134 (134; 3):666-76. [Full Text/Abstract]
Chen AW, Koh YT, Leong SW, Ng LW, Lee PS, Koh GCh. Post Community Hospital Discharge Rehabilitation Attendance: Self-Perceived Barriers and Participation over Time. Ann Acad Med Singapore. 43 (43; 3):136-44. [Full Text/Abstract]
Gerstein M, Sukhdeo S, Levy DM, Feldman BM, Benseler SM, Ng LW, Abdelhaleem M, Silverman ED, Hiraki L. A15: predicting macrophage activation syndrome in pediatric systemic lupus erythematosus patients at diagnosis. Arthritis Rheumatol. 66 Suppl 11 (66 Suppl 11):S25. [Full Text/Abstract]
Ng LP, Goh P. Incidence of discontinuation of angiotensin-converting enzyme inhibitors due to cough, in a primary healthcare centre in Singapore. Singapore Med J. 55 (55; 3):146-9. [Full Text/Abstract]
Mountford SJ, Albiston AL, Charman WN, Ng L, Holien JK, Parker MW, Nicolazzo JA, Thompson PE, Chai SY. Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase. J Med Chem. 2014 Feb 27; 57 (4; 2014 Feb 27; 57):1368-77. [Full Text/Abstract]
Dames EL, Ng LG, Tay KH. Congenital renal arteriovenous malformation presenting with gross hematuria after a routine jog: a case report. J Med Case Rep. 8 (8; 1):65. [Full Text/Abstract]
Daly CE, Ng LL, Hakimi A, Willingale R, Jones DJ. Qualitative and quantitative characterization of plasma proteins when incorporating traveling wave ion mobility into a liquid chromatography-mass spectrometry workflow for biomarker discovery: use of product ion quantitation as an alternative data analysis tool for label free quantitation. Anal Chem. 86 (86; 4):1972-9. [Full Text/Abstract]
Wu TH, Cheng YY, Chen CJ, Ng LT, Chou LC, Huang LJ, Chen YH, Kuo SC, El-Shazly M, Wu YC, Chang FR, Liaw CC. Three new clerodane diterpenes from Polyalthia longifolia var. pendula. Molecules. 19 (19; 2):2049-60. [Full Text/Abstract]
Claser C, Malleret B, Peng K, Bakocevic N, Gun SY, Russell B, Ng LG, Rénia L. Rodent Plasmodium-infected red blood cells: imaging their fates and interactions within their hosts. Parasitol Int. 63 (63; 1):187-94. [Full Text/Abstract]
Tan TY, Cheng Y, Ong M, Ng LS. Performance characteristics and clinical predictive value of the string test for detection of hepato-virulent Klebsiella pneumoniae isolated from blood cultures. Diagn Microbiol Infect Dis. 2014 Feb; 78 (2; 2014 Feb; 78):127-8. [Full Text/Abstract]
Bhandari SS, Davies JE, Struck J, Ng LL. Plasma C-terminal proEndothelin-1 (CTproET-1) is affected by age, renal function, left atrial size and diastolic blood pressure in healthy subjects. Peptides. 52 (52):53-7. [Full Text/Abstract]
Chan MF, Tan HY, Lian X, Ng LY, Ang LL, Lim LH, Ng WM, Tan MC, Taylor BJ. A randomized controlled study to compare the 2% lignocaine and aqueous lubricating gels for female urethral catheterization. Pain Pract. 14 (14; 2):140-5. [Full Text/Abstract]
Ng LL, Sandhu JK, Narayan H, Quinn PA, Squire IB, Davies JE, Bergmann A, Maisel A, Jones DJ. Proenkephalin and prognosis after acute myocardial infarction. J Am Coll Cardiol. 63 (63; 3):280-9. [Full Text/Abstract]
Tam ZY, Gruber J, Ng LF, Halliwell B, Gunawan R. Effects of Lithium on Age-related Decline in Mitochondrial Turnover and Function in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. [Full Text/Abstract]
Robinson BM, Zhang J, Morgenstern H, Bradbury BD, Ng LJ, McCullough KP, Gillespie BW, Hakim R, Rayner H, Fort J, Akizawa T, Tentori F, Pisoni RL. Worldwide, mortality risk is high soon after initiation of hemodialysis. Kidney Int. 85 (85; 1):158-65. [Full Text/Abstract]