U.S. Department of Health and Human Services
Luis Menezes

 Contact Info

Tel: 301-451-9614
Email: menezeslf@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2012–Present
  • Postdoctoral FellowNIDDK, NIH2009–2012
  • Postdoctoral FellowJohns Hopkins School of Medicine2005–2009
  • Human Pathology SpecialistSchool of Medicine, University of São Paulo1999–2001
  • Ph.D.School of Medicine, University of São Paulo2004
  • M.D.School of Medicine, State University of Campinas, Campinas1998

 Related Links


Luis Fernando Menezes, M.D., Ph.D.

Staff Scientist, Polycystic Kidney Disease LaboratoryKidney Diseases Branch
  • Pathophysiology of Kidney Disease


A selection of recent and significant publications can be viewed below.

Menezes LF, Lin CC, Zhou F, Germino GG. Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease. EBioMedicine. 2016 Mar; 5 (2016 Mar; 5):183-92. [Full Text/Abstract]
Menezes LF, Germino GG. Systems biology of polycystic kidney disease: a critical review. Wiley Interdiscip Rev Syst Biol Med. 2015 Feb 2; 7 (7; 2015 Feb 2; 1):39-52. [Full Text/Abstract]
Lee YL, Santé J, Comerci CJ, Cyge B, Menezes LF, Li FQ, Germino GG, Moerner WE, Takemaru K, Stearns T. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. Mol Biol Cell. 2014 Aug 7; 25 (25; 19; 2014 Aug 7):2919-33. [Full Text/Abstract]
Menezes LF, Germino GG. Murine Models of Polycystic Kidney Disease. Drug Discov Today Dis Mech. 2013 Dec 1; 10 (3-4; 2013 Dec 1; 10):e153-e158. [Full Text/Abstract]
Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier. PLoS Genet. 2012; 8 (2012; 8; 11):e1003053. [Full Text/Abstract]
Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T. Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010 Sep 16; 5 (9; 5; 2010 Sep 16). [Full Text/Abstract]
Bastos AP, Piontek K, Silva AM, Martini D, Menezes LF, Fonseca JM, Fonseca II, Germino GG, Onuchic LF. Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion. J Am Soc Nephrol. 2009 Nov; 20 (20; 2009 Nov; 11):2389-402. [Full Text/Abstract]
Menezes LF, Germino GG. Polycystic kidney disease, cilia, and planar polarity. Methods Cell Biol. 2009; 94 (94; 2009):273-97. [Full Text/Abstract]
Gallagher AR, Esquivel EL, Briere TS, Tian X, Mitobe M, Menezes LF, Markowitz GS, Jain D, Onuchic LF, Somlo S. Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1. Am J Pathol. 2008 Feb; 172 (2; 172; 2008 Feb):417-29. [Full Text/Abstract]
Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med. 2007 Dec; 13 (2007 Dec; 12; 13):1490-5. [Full Text/Abstract]
Yu S, Hackmann K, Gao J, He X, Piontek K, García-González MA, Menezes LF, Xu H, Germino GG, Zuo J, Qian F. Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20; 104 (104; 2007 Nov 20; 47):18688-93. [Full Text/Abstract]
Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007 Aug 15; 16 (2007 Aug 15; 16):1940-50. [Full Text/Abstract]
Kaimori JY, Nagasawa Y, Menezes LF, Garcia-Gonzalez MA, Deng J, Imai E, Onuchic LF, Guay-Woodford LM, Germino GG. Polyductin undergoes notch-like processing and regulated release from primary cilia. Hum Mol Genet. 2007 Apr 15; 16 (8; 16; 2007 Apr 15):942-56. [Full Text/Abstract]
Menezes LF, Cai Y, Nagasawa Y, Silva AM, Watkins ML, Da Silva AM, Somlo S, Guay-Woodford LM, Germino GG, Onuchic LF. Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm. Kidney Int. 2004 Oct; 66 (66; 2004 Oct; 4):1345-55. [Full Text/Abstract]