U.S. Department of Health and Human Services
Luis Menezes

 Contact Info

Tel: 301-451-9614
Email: menezeslf@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2012–Present
  • Postdoctoral FellowNIDDK, NIH2009–2012
  • Postdoctoral FellowJohns Hopkins School of Medicine2005–2009
  • Human Pathology SpecialistSchool of Medicine, University of São Paulo1999–2001
  • Ph.D.School of Medicine, University of São Paulo2004
  • M.D.School of Medicine, State University of Campinas, Campinas1998

 Related Links


Luis Fernando Menezes, M.D., Ph.D.

Staff Scientist, Polycystic Kidney Disease LaboratoryKidney Diseases Branch
  • Pathophysiology of Kidney Disease
Research Summary/In Plain Language

Research in Plain Language

An important component of the kidney are the tubes that make urine. These tubes, as the name implies, are usually long channels through which the urine flows. In polycystic kidney disease (PKD), these tubes start to dilate and can become large balls (cysts) filled with fluid. Sometimes they are disconnected from the other tubes and are no longer capable of making urine. This results in the kidney not working properly. We study the mechanisms responsible for the tubes becoming cystic using genetically engineered mice that have a form of and cell lines that mimic some of the characteristics of PKD.