U.S. Department of Health and Human Services

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Schematic of HBV replication and drug targetsThe virus enters the hepatocyte using the sodium taurocholate cotransporting polypeptide as a receptor. cccDNA is generated by repairing the partially double stranded genome in the nucleus, whereupon viral transcription occurs. Encapsidation of the pregenomic RNA occurs in the cytoplasm via a complex interaction of viral and host proteins. Reverse transcription leading to negative and then positive strand synthesis occurs within the viral nucleocapsid. Viral assembly takes place in the ER. “Mature” nucleocapsids undergo assembly and coating with envelope proteins followed by budding and virion secretion into the blood. Potential targets for drug development are highlighted.Schematic of HBV replication and drug targetsEnlarge