U.S. Department of Health and Human Services
Maria Allende

 Contact Info

Tel: 301-496-8356
Email: mariaa@intra.niddk.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2005–present
  • Research FellowNIDDK, NIH1999–2005
  • Postdoctoral Research AssociateSchool of Dentistry, University of Louisville1996–1999
  • Postdoctoral FellowSchool of Chemical Sciences, National University of Cordoba1995–1996
  • Doctoral FellowSchool of Chemical Sciences, National University of Cordoba1991–1995
  • InstructorSchool of Chemical Sciences, National University of Cordoba1990-1996
  • Ph.D.School of Chemical Sciences, National University of Cordoba, Argentina1995
  • ChemistSchool of Chemical Sciences, National University of Cordoba, Argentina1985-1989

 Related Links

  • Cell Biology/Cell Signaling


A selection of recent and significant publications can be viewed below.

Allende ML, Cook EK, Larman BC, Nugent A, Brady JM, Golebiowski D, Sena-Esteves M, Tifft CJ, Proia RL. Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation. J Lipid Res. 2018 Jan 22; 59 (59; 2018 Jan 22; 3):550-563. [Full Text/Abstract]
Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL. De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem. 2017 Jan 18; 292 (292; 2017 Jan 18; 9):3929-3939. [Full Text/Abstract]
Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL. Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation. J Biol Chem. 2016 Apr 8; 291 (291; 2016 Apr 8; 23):12029-38. [Full Text/Abstract]
Allende ML, Proia RL. Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function. Glycoconj J. 2014 Oct 29; 31 (9; 31; 2014 Oct 29):613-22. [Full Text/Abstract]
Olivera A, Kitamura Y, Wright LD, Allende ML, Chen W, Kaneko-Goto T, Yoshihara Y, Proia RL, Rivera J. Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. J Leukoc Biol. 2013 Nov; 94 (94; 2013 Nov; 5):1013-24. [Full Text/Abstract]
Allende ML, Sipe LM, Tuymetova G, Wilson-Henjum KL, Chen W, Proia RL. Sphingosine-1-phosphate Phosphatase 1 Regulates Keratinocyte Differentiation and Epidermal Homeostasis. J Biol Chem. 2013 Jun 21; 288 (25; 2013 Jun 21; 288):18381-91. [Full Text/Abstract]
Olivera A, Allende ML, Proia RL. Shaping the landscape: metabolic regulation of S1P gradients. Biochim Biophys Acta. 2013 Jan; 1831 (1831; 1; 2013 Jan):193-202. [Full Text/Abstract]
Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem. 2011 Mar 4; 286 (9; 286; 2011 Mar 4):7348-58. [Full Text/Abstract]
Allende ML, Tuymetova G, Lee BG, Bonifacino E, Wu YP, Proia RL. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med. 2010 May 10; 207 (207; 5; 2010 May 10):1113-24. [Full Text/Abstract]
Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem. 2010 Apr 2; 285 (2010 Apr 2; 14; 285):10880-9. [Full Text/Abstract]
Kono M, Allende ML, Proia RL. Sphingosine-1-phosphate regulation of mammalian development. Biochim Biophys Acta. 2008 Sep; 1781 (1781; 9; 2008 Sep):435-41. [Full Text/Abstract]
Allende ML, Dreier JL, Mandala S, Proia RL. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem. 2004 Apr 9; 279 (2004 Apr 9; 15; 279):15396-401. [Full Text/Abstract]
Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22; 427 (6972; 2004 Jan 22; 427):355-60. [Full Text/Abstract]
Allende ML, Yamashita T, Proia RL. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15; 102 (102; 2003 Nov 15; 10):3665-7. [Full Text/Abstract]