U.S. Department of Health and Human Services
Mark Levine

 Contact Info

Tel: 301-402-5588
Email: markl@mail.nih.gov

 Select Experience

  • NIH Fellowship in Endocrinology and MetabolismInterinstitute Endocrinology Training Program1980-1983
  • Internship and ResidencyOsler Medical Service, Johns Hopkins Hospital1977-1980
  • M.D.Harvard Medical School1977
  • B.A.Brandeis University1973

 Related Links

  • Clinical Research
  • Molecular Biology/Biochemistry
  • Molecular Pharmacology/Toxicology
  • Nutrition Sciences


A selection of recent and significant publications can be viewed below.

Padayatty SJ, Levine M. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer. Ann Intern Med. 2014 May 6; 160 (2014 May 6; 160; 9):654. [Full Text/Abstract]
Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med. 2014 Feb 5; 6 (222; 6; 2014 Feb 5):222ra18. [Full Text/Abstract]
Parrow NL, Leshin JA, Levine M. Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics. Antioxid Redox Signal. 2013 Dec 10; 19 (2013 Dec 10; 19; 17):2141-56. [Full Text/Abstract]
Eck P, Kwon O, Chen S, Mian O, Levine M. The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell. Physiol Rep. 2013 Nov; 1 (6; 2013 Nov; 1):e00136. [Full Text/Abstract]
Shatzer AN, Espey MG, Chavez M, Tu H, Levine M, Cohen JI. Ascorbic acid kills Epstein-Barr virus positive Burkitt lymphoma cells and Epstein-Barr virus transformed B-cells in vitro, but not in vivo. Leuk Lymphoma. 2013 May; 54 (2013 May; 5; 54):1069-78. [Full Text/Abstract]
Corpe CP, Eck P, Wang J, Al-Hasani H, Levine M. Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. J Biol Chem. 2013 Mar 29; 288 (288; 13; 2013 Mar 29):9092-101. [Full Text/Abstract]
Welsh JL, Wagner BA, van't Erve TJ, Zehr PS, Berg DJ, Halfdanarson TR, Yee NS, Bodeker KL, Du J, Roberts LJ 2nd, Drisko J, Levine M, Buettner GR, Cullen JJ. Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemother Pharmacol. 2013 Mar; 71 (2013 Mar; 71; 3):765-75. [Full Text/Abstract]
Padayatty SJ, Levine M. Standard-dose vs high-dose multivitamin supplements for HIV. JAMA. 2013 Feb 13; 309 (309; 2013 Feb 13; 6):545-6. [Full Text/Abstract]
Li H, Tu H, Wang Y, Levine M. Vitamin C in mouse and human red blood cells: an HPLC assay. Anal Biochem. 2012 Jul 15; 426 (2; 2012 Jul 15; 426):109-17. [Full Text/Abstract]
Eisner C, Ow H, Yang T, Jia Z, Dimitriadis E, Li L, Wang K, Briggs J, Levine M, Schnermann J, Espey MG. Measurement of plasma volume using fluorescent silica-based nanoparticles. J Appl Physiol (1985). 2012 Feb; 112 (2012 Feb; 4; 112):681-7. [Full Text/Abstract]
Monti DA, Mitchell E, Bazzan AJ, Littman S, Zabrecky G, Yeo CJ, Pillai MV, Newberg AB, Deshmukh S, Levine M. Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS One. 2012; 7 (2012; 7; 1):e29794. [Full Text/Abstract]
Dusing RW, Drisko JA, Grado GG, Levine M, Holzbeierlein JM, Van Veldhuizen P. Prostate imaging modalities that can be used for complementary and alternative medicine clinical studies. Urol Clin North Am. 2011 Aug; 38 (38; 3; 2011 Aug):343-57. [Full Text/Abstract]
Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, Levine M, Chen Q. Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med. 2011 Jun 1; 50 (2011 Jun 1; 50; 11):1610-9. [Full Text/Abstract]
Levine M, Padayatty SJ, Espey MG. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv Nutr. 2011 Mar; 2 (2; 2011 Mar):78-88. [Full Text/Abstract]
Finkelstein FO, Juergensen P, Wang S, Santacroce S, Levine M, Kotanko P, Levin NW, Handelman GJ. Hemoglobin and plasma vitamin C levels in patients on peritoneal dialysis. Perit Dial Int. 2011 Jan-Feb; 31 (2011 Jan-Feb; 1; 31):74-9. [Full Text/Abstract]
Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 7; 5 (2010 Jul 7; 7; 5):e11414. [Full Text/Abstract]
Pollard HB, Levine MA, Eidelman O, Pollard M. Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer. In Vivo. 2010 May-Jun; 24 (3; 24; 2010 May-Jun):249-55. [Full Text/Abstract]
Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest. 2010 Apr; 120 (120; 4; 2010 Apr):1069-83. [Full Text/Abstract]
Eisner C, Faulhaber-Walter R, Wang Y, Leelahavanichkul A, Yuen PS, Mizel D, Star RA, Briggs JP, Levine M, Schnermann J. Major contribution of tubular secretion to creatinine clearance in mice. Kidney Int. 2010 Mar; 77 (77; 6; 2010 Mar):519-26. [Full Text/Abstract]
Du J, Martin SM, Levine M, Wagner BA, Buettner GR, Wang SH, Taghiyev AF, Du C, Knudson CM, Cullen JJ. Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res. 2010 Jan 15; 16 (2010 Jan 15; 16; 2):509-20. [Full Text/Abstract]
Espey MG, Chen Q, Levine M. Comment re: Vitamin C antagonizes the cytotoxic effects of chemotherapy. Cancer Res. 2009 Nov 15; 69 (69; 2009 Nov 15; 22):8830; author reply 8830-1. [Full Text/Abstract]
Levine M, Eck P. Vitamin C: working on the x-axis. Am J Clin Nutr. 2009 Nov; 90 (5; 2009 Nov; 90):1121-3. [Full Text/Abstract]
Levine M, Espey MG, Chen Q. Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic Biol Med. 2009 Jul 1; 47 (2009 Jul 1; 1; 47):27-9. [Full Text/Abstract]
Padayatty SJ, Levine M. Antioxidant supplements and cardiovascular disease in men. JAMA. 2009 Apr 1; 301 (2009 Apr 1; 13; 301):1336; author reply 1336-7. [Full Text/Abstract]
Robitaille L, Mamer OA, Miller WH Jr, Levine M, Assouline S, Melnychuk D, Rousseau C, Hoffer LJ. Oxalic acid excretion after intravenous ascorbic acid administration. Metabolism. 2009 Feb; 58 (2009 Feb; 2; 58):263-9. [Full Text/Abstract]
Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, Rousseau C, Robitaille L, Miller WH Jr. Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol. 2008 Nov; 19 (19; 2008 Nov; 11):1969-74. [Full Text/Abstract]
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008 Aug 12; 105 (105; 32; 2008 Aug 12):11105-9. [Full Text/Abstract]
Horemans N, Szarka A, De Bock M, Raeymaekers T, Potters G, Levine M, Banhégyi G, Guisez Y. Dehydroascorbate and glucose are taken up into Arabidopsis thaliana cell cultures by two distinct mechanisms. FEBS Lett. 2008 Aug 6; 582 (582; 2008 Aug 6; 18):2714-8. [Full Text/Abstract]
Padayatty SJ, Levine M. Fruit and vegetables: think variety, go ahead, eat!. Am J Clin Nutr. 2008 Jan; 87 (87; 2008 Jan; 1):5-7. [Full Text/Abstract]
Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell. 2008 Jan; 19 (19; 2008 Jan; 1):86-94. [Full Text/Abstract]
Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, Hayes RB, Chanock S. Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer. 2008; 60 (60; 2008; 5):652-9. [Full Text/Abstract]
Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M. Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone. Am J Clin Nutr. 2007 Jul; 86 (86; 2007 Jul; 1):145-9. [Full Text/Abstract]
Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104 (104; 21; 2007 May 22):8749-54. [Full Text/Abstract]
Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M, Levine M. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J. 2007 Feb; 21 (2; 21; 2007 Feb):366-77. [Full Text/Abstract]