U.S. Department of Health and Human Services
Martin Gellert

 Contact Info

Tel: 301-451-8168
Email: gellert@helix.nih.gov

 Select Experience

  • Ph.D.Columbia University1956
  • B.A.Harvard University1950

 Related Links


Martin Gellert, Ph.D., NIH Distinguished Investigator

Section Chief, Molecular Genetics SectionLaboratory of Molecular Biology
  • Chromosome Biology/Epigenetics
  • Immunology
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Singh SK, Gellert M. Role of RAG1 autoubiquitination in V(D)J recombination. Proc Natl Acad Sci U S A. 2015 Jun 29; 112 (2015 Jun 29; 28; 112):8579-8583. [Full Text/Abstract]
Lapkouski M, Chuenchor W, Kim MS, Gellert M, Yang W. Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end Complexes. J Biol Chem. 2015 Apr 22; 290 (23; 2015 Apr 22; 290):14618-25. [Full Text/Abstract]
Kim MS, Lapkouski M, Yang W, Gellert M. Crystal structure of the V(D)J recombinase RAG1-RAG2. Nature. 2015 Feb 18; 518 (7540; 518; 2015 Feb 18):507-511. [Full Text/Abstract]
Um JH, Brown AL, Singh SK, Chen Y, Gucek M, Lee BS, Luckey MA, Kim MK, Park JH, Sleckman BP, Gellert M, Chung JH. Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination. Proc Natl Acad Sci U S A. 2013 Jun 11; 110 (110; 24; 2013 Jun 11):9873-8. [Full Text/Abstract]
Gupta S, Gellert M, Yang W. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops. Nat Struct Mol Biol. 2011 Dec 18; 19 (2011 Dec 18; 19; 1):72-8. [Full Text/Abstract]
Dayal S, Nedbal J, Hobson P, Cooper AM, Gould HJ, Gellert M, Felsenfeld G, Fear DJ. High resolution analysis of the chromatin landscape of the IgE switch region in human B cells. PLoS One. 2011; 6 (2011; 6; 9):e24571. [Full Text/Abstract]
Grundy GJ, Yang W, Gellert M. Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination. Proc Natl Acad Sci U S A. 2010 Dec 28; 107 (107; 2010 Dec 28; 52):22487-92. [Full Text/Abstract]
Grundy GJ, Ramón-Maiques S, Dimitriadis EK, Kotova S, Biertümpfel C, Heymann JB, Steven AC, Gellert M, Yang W. Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex. Mol Cell. 2009 Jul 31; 35 (2009 Jul 31; 35; 2):217-27. [Full Text/Abstract]
Grundy GJ, Hesse JE, Gellert M. Requirements for DNA hairpin formation by RAG1/2. Proc Natl Acad Sci U S A. 2007 Feb 27; 104 (104; 2007 Feb 27; 9):3078-83. [Full Text/Abstract]
Jones JM, Gellert M. Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc Natl Acad Sci U S A. 2003 Dec 23; 100 (2003 Dec 23; 100; 26):15446-51. [Full Text/Abstract]