U.S. Department of Health and Human Services
Marvin Gershengorn

 Contact Info

Tel: 301-451-6305
Email: marving@mail.nih.gov

 Select Experience

  • Abby Rockefeller Mauzé Distinguished Professor of Endocrinology in MedicineCornell University Medical College1983–2001
  • Chief of the Division of Endocrinology and MetabolismCornell University Medical College1983–2001
  • Professor of Medicine and Cell Biology and GeneticsCornell University Medical College1983–2001
  • Assistant and Associate ProfessorNew York University School of Medicine1976–1983
  • M.D.New York University School of Medicine1971
  • B.S.City College of the City University of New York1967

 Related Links

  •  Molecular Pharmacology/Toxicology
  • Endocrinology


A selection of recent and significant publications can be viewed below.

Krieger CC, Place RF, Bevilacqua C, Marcus-Samuels B, Abel BS, Skarulis MC, Kahaly GJ, Neumann S, Gershengorn MC. TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis. J Clin Endocrinol Metab. 2016 Apr 4; 101 (6; 2016 Apr 4; 101):2340-7. [Full Text/Abstract]
Boutin A, Neumann S, Gershengorn MC. Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells. Endocrinology. 2016 Mar 7; 157 (157; 2016 Mar 7; 5):2173-2181. [Full Text/Abstract]
Krieger CC, Neumann S, Place RF, Marcus-Samuels B, Gershengorn MC. Bidirectional TSH and IGF-1 Receptor Cross Talk Mediates Stimulation of Hyaluronan Secretion by Graves' Disease Immunoglobins. J Clin Endocrinol Metab. 2014 Dec 8; 100 (100; 2014 Dec 8; 3):1071-7. [Full Text/Abstract]
Boutin A, Eliseeva E, Gershengorn MC, Neumann S. β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. FASEB J. 2014 Aug; 28 (28; 8; 2014 Aug):3446-55. [Full Text/Abstract]
Katz LS, Geras-Raaka E, Gershengorn MC. Heritability of fat accumulation in white adipocytes. Am J Physiol Endocrinol Metab. 2014 Aug 1; 307 (307; 2014 Aug 1; 3):E335-44. [Full Text/Abstract]
Hiram-Bab S, Katz LS, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol. 2014 Jun; 229 (229; 6; 2014 Jun):743-51. [Full Text/Abstract]
Krieger CC, Gershengorn MC. A modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cells. Endocrinology. 2014 Feb; 155 (155; 2; 2014 Feb):627-34. [Full Text/Abstract]
Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan; 155 (155; 2014 Jan; 1):310-4. [Full Text/Abstract]
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. Thyroid. 2012 Aug; 22 (2012 Aug; 8; 22):839-43. [Full Text/Abstract]
Boutin A, Allen MD, Neumann S, Gershengorn MC. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB J. 2012 Aug; 26 (2012 Aug; 8; 26):3473-82. [Full Text/Abstract]
Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence. Thyroid. 2011 Aug; 21 (8; 21; 2011 Aug):907-12. [Full Text/Abstract]
Boutin A, Allen MD, Geras-Raaka E, Huang W, Neumann S, Gershengorn MC. Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. Mol Pharmacol. 2011 Aug; 80 (2; 80; 2011 Aug):240-6. [Full Text/Abstract]
Monga V, Meena CL, Rajput S, Pawar C, Sharma SS, Lu X, Gershengorn MC, Jain R. Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues. ChemMedChem. 2011 Mar 7; 6 (6; 2011 Mar 7; 3):531-43. [Full Text/Abstract]
Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb; 96 (2; 2011 Feb; 96):548-54. [Full Text/Abstract]
Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G. Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. Cell Mol Life Sci. 2011 Jan; 68 (68; 2011 Jan; 1):159-67. [Full Text/Abstract]
Neumann S, Geras-Raaka E, Marcus-Samuels B, Gershengorn MC. Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization. FASEB J. 2010 Oct; 24 (2010 Oct; 10; 24):3992-9. [Full Text/Abstract]
Neumann S, Huang W, Eliseeva E, Titus S, Thomas CJ, Gershengorn MC. A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Endocrinology. 2010 Jul; 151 (7; 2010 Jul; 151):3454-9. [Full Text/Abstract]
Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G. Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. FASEB J. 2010 Jul; 24 (7; 2010 Jul; 24):2347-54. [Full Text/Abstract]
Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28; 106 (106; 2009 Jul 28; 30):12471-6. [Full Text/Abstract]
Sun Y, Zupan B, Raaka BM, Toth M, Gershengorn MC. TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes. Neuropsychopharmacology. 2009 May; 34 (6; 34; 2009 May):1601-8. [Full Text/Abstract]