U.S. Department of Health and Human Services
Marvin Gershengorn

 Contact Info

Tel: 301-451-6305
Email: marving@mail.nih.gov

 Select Experience

  • Abby Rockefeller Mauzé Distinguished Professor of Endocrinology in MedicineCornell University Medical College1983–2001
  • Chief of the Division of Endocrinology and MetabolismCornell University Medical College1983–2001
  • Professor of Medicine and Cell Biology and GeneticsCornell University Medical College1983–2001
  • Assistant and Associate ProfessorNew York University School of Medicine1976–1983
  • M.D.New York University School of Medicine1971
  • B.S.City College of the City University of New York1967

 Related Links

  •  Molecular Pharmacology/Toxicology
  • Endocrinology

​Research Images

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Ligand binding to thyroid-stimulating hormone (TSH) receptorThe thyroid-stimulating hormone (TSH), autoantibodies (TSAbs), and small molecule drug-like ligands (SMLs) bind to the TSH receptor at different sites. TSH and TSAbs bind primarily to the large ectodomain, whereas SMLs bind to a pocket within the transmembrane domain. Ectodomain is in red while the Transmembrane domain’s individual helices are ribbons in different colors.Ligand binding to thyroid-stimulating hormone (TSH) receptorEnlarge
Internalization of thyroid-stimulating hormone (TSH) receptorsThyroid-stimulating hormone (TSH) receptors (TSHRs) are stimulated to internalize by TSH in a β-arrestin-2-mediated pathway. Internalization of TSHRs (Control cells) are internalized to a greater extent when β-arrestin-2 is co-expressed with TSHRs (β-arrestin-2). The punctate spots are clusters of internalized TSHRs.Internalization of thyroid-stimulating hormone (TSH) receptorsEnlarge