U.S. Department of Health and Human Services
Michael Krause

 Contact Info

Tel: 301-402-4633
Email: michaelkr@niddk.nih.gov

 Select Experience

  • Laboratory of Molecular BiologyNIDDK, NIH1993–Present
  • Postdoctoral FellowFred Hutchinson Cancer Research Center1986–1992
  • Ph.D.University of Colorado1986
  • B.A.University of Colorado1978

 Related Links


Michael W. Krause, Ph.D.

Scientific Director, Division of Intramural Research
Section Chief, Develop​mental Biology SectionLaboratory of Molecular Biology

Specialties: Developmental Biology

Michael W. Krause, Ph.D.

Section Chief, Developmental Biology SectionLaboratory of Molecular Biology
Scientific Director, Division of Intramural Research
Scientific Director, Office of Scientific Director
  • Developmental Biology


A selection of recent and significant publications can be viewed below.

Kersey RK, Brodigan TM, Fukushige T, Krause MW. Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans. Dev Biol. 2016 Jun 21; 416 (2; 2016 Jun 21; 416):300-11. [Full Text/Abstract]
Thompson KW, Joshi P, Dymond JS, Gorrepati L, Smith HE, Krause MW, Eisenmann DM. The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans. Dev Biol. 2016 Mar 4; 412 (2016 Mar 4; 412; 2):191-207. [Full Text/Abstract]
Gorrepati L, Krause MW, Chen W, Brodigan TM, Correa-Mendez M, Eisenmann DM. Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans. G3 (Bethesda). 2015 Jun 5; 5 (2015 Jun 5; 8; 5):1551-66. [Full Text/Abstract]
Liu Z, Shi H, Szymczak LC, Aydin T, Yun S, Constas K, Schaeffer A, Ranjan S, Kubba S, Alam E, McMahon DE, He J, Shwartz N, Tian C, Plavskin Y, Lindy A, Dad NA, Sheth S, Amin NM, Zimmerman S, Liu D, Schwarz EM, Smith H, Krause MW, Liu J. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genet. 2015 May; 11 (2015 May; 5; 11):e1005221. [Full Text/Abstract]
Paix A, Wang Y, Smith HE, Lee CY, Calidas D, Lu T, Smith J, Schmidt H, Krause MW, Seydoux G. Scalable and Versatile Genome Editing Using Linear DNAs with Micro-Homology to Cas9 Sites in Caenorhabditis elegans. Genetics. 2014 Sep 23; 198 (2014 Sep 23; 4; 198):1347-56. [Full Text/Abstract]
Jackson BM, Abete-Luzi P, Krause MW, Eisenmann DM. Use of an Activated Beta-Catenin to Identify Wnt Pathway Target Genes in Caenorhabditis elegans, Including a Subset of Collagen Genes Expressed in Late Larval Development. G3 (Bethesda). 2014 Apr 16; 4 (2014 Apr 16; 4):733-47. [Full Text/Abstract]
Ghosh SK, Bond MR, Love DC, Ashwell GG, Krause MW, Hanover JA. Disruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans. Front Endocrinol (Lausanne). 2014 Nov 24; 5 (2014 Nov 24; 5):197. [Full Text/Abstract]
Reinke V, Krause M, Okkema P. Transcriptional regulation of gene expression in C. elegans. WormBook. 2013 Jun 4; (2013 Jun 4):1-31. [Full Text/Abstract]
Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW. O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics. 2011 Jun; 188 (188; 2; 2011 Jun):369-82. [Full Text/Abstract]
Lei H, Fukushige T, Niu W, Sarov M, Reinke V, Krause M. A widespread distribution of genomic CeMyoD binding sites revealed and cross validated by ChIP-Chip and ChIP-Seq techniques. PLoS One. 2010 Dec 29; 5 (2010 Dec 29; 12; 5):e15898. [Full Text/Abstract]
Love DC, Krause MW, Hanover JA. O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol. 2010 Aug; 21 (6; 2010 Aug; 21):646-54. [Full Text/Abstract]
Severance S, Rajagopal A, Rao AU, Cerqueira GC, Mitreva M, El-Sayed NM, Krause M, Hamza I. Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genet. 2010 Jul 29; 6 (2010 Jul 29; 6; 7):e1001044. [Full Text/Abstract]
Love DC, Ghosh S, Mondoux MA, Fukushige T, Wang P, Wilson MA, Iser WB, Wolkow CA, Krause MW, Hanover JA. Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A. 2010 Apr 20; 107 (2010 Apr 20; 107; 16):7413-8. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta. 2010 Feb; 1800 (2; 1800; 2010 Feb):80-95. [Full Text/Abstract]
Lei H, Liu J, Fukushige T, Fire A, Krause M. Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network. Development. 2009 Apr; 136 (2009 Apr; 8; 136):1241-9. [Full Text/Abstract]
McGhee JD, Fukushige T, Krause MW, Minnema SE, Goszczynski B, Gaudet J, Kohara Y, Bossinger O, Zhao Y, Khattra J, Hirst M, Jones SJ, Marra MA, Ruzanov P, Warner A, Zapf R, Moerman DG, Kalb JM. ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult. Dev Biol. 2009 Mar 15; 327 (327; 2; 2009 Mar 15):551-65. [Full Text/Abstract]
Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M, Hamza I. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature. 2008 Jun 19; 453 (453; 7198; 2008 Jun 19):1127-31. [Full Text/Abstract]
Fukushige T, Brodigan TM, Schriefer LA, Waterston RH, Krause M. Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development. Genes Dev. 2006 Dec 15; 20 (20; 24; 2006 Dec 15):3395-406. [Full Text/Abstract]