U.S. Department of Health and Human Services
Min Chen

 Contact Info

Tel: 301-496-0790
Email: minc@intra.niddk.nih.gov

 Select Experience

  • Staff ScientistMetabolic Diseases Branch, NIDDK, NIH2000–present
  • Senior Staff FellowNIDDK, NIH1998–2000
  • Postdoctoral FellowNational Human Genome Research Institute (NHGRI), NIH1994–1998
  • Senior ScientistDepartment of Preclinic Pharmacology, Gene Medicine, Inc.1993–1994
  • Clinical Research FellowUniversity of Michigan Medical School1986–1988
  • Ph.D.University of Michigan1993
  • M.D.Fourth Military Medical University 1983

 Related Links


Min Chen, M.D., Ph.D.

Staff Scientist, Signal Transduction SectionMetabolic Diseases Branch
  • Cell Biology/Cell Signaling
  • Metabolism
  • Obesity


A selection of recent and significant publications can be viewed below.

Chen M, Berger A, Kablan A, Zhang J, Gavrilova O, Weinstein LS. Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations. Endocrinology. 2012 Sep; 153 (153; 2012 Sep; 9):4256-65. [Full Text/Abstract]
Chen M, Mema E, Kelleher J, Nemechek N, Berger A, Wang J, Xie T, Gavrilova O, Drucker DJ, Weinstein LS. Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency. Endocrinology. 2011 Sep; 152 (2011 Sep; 152; 9):3343-50. [Full Text/Abstract]
Chen M, Nemechek NM, Mema E, Wang J, Weinstein LS. Effects of deficiency of the G protein Gsα on energy and glucose homeostasis. Eur J Pharmacol. 2011 Jun 11; 660 (660; 2011 Jun 11; 1):119-24. [Full Text/Abstract]
Xie T, Chen M, Weinstein LS. Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation. J Endocrinol. 2010 Sep; 206 (206; 2010 Sep; 3):261-9. [Full Text/Abstract]
Chen M, Chen H, Nguyen A, Gupta D, Wang J, Lai EW, Pacak K, Gavrilova O, Quon MJ, Weinstein LS. G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. Cell Metab. 2010 Apr 7; 11 (2010 Apr 7; 4; 11):320-30. [Full Text/Abstract]
Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS. Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab. 2009 Jun; 9 (6; 9; 2009 Jun):548-55. [Full Text/Abstract]
Chen M, Feng HZ, Gupta D, Kelleher J, Dickerson KE, Wang J, Hunt D, Jou W, Gavrilova O, Jin JP, Weinstein LS. G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. Am J Physiol Cell Physiol. 2009 Apr; 296 (2009 Apr; 296; 4):C930-40. [Full Text/Abstract]
Feng HZ, Chen M, Weinstein LS, Jin JP. Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling. J Biol Chem. 2008 Nov 28; 283 (48; 283; 2008 Nov 28):33384-93. [Full Text/Abstract]
Xie T, Chen M, Zhang QH, Ma Z, Weinstein LS. Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes. Proc Natl Acad Sci U S A. 2007 Dec 4; 104 (104; 49; 2007 Dec 4):19601-6. [Full Text/Abstract]
Weinstein LS, Xie T, Zhang QH, Chen M. Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology. Pharmacol Ther. 2007 Aug; 115 (2007 Aug; 2; 115):271-91. [Full Text/Abstract]
Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest. 2005 Nov; 115 (2005 Nov; 115; 11):3217-27. [Full Text/Abstract]
Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT, Nackers LM, Lorenzo J, Shen L, Weinstein LS. Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A. 2005 May 17; 102 (2005 May 17; 20; 102):7386-91. [Full Text/Abstract]
Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS. Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. Proc Natl Acad Sci U S A. 2005 Apr 12; 102 (102; 2005 Apr 12; 15):5513-8. [Full Text/Abstract]
Chen M, Haluzik M, Wolf NJ, Lorenzo J, Dietz KR, Reitman ML, Weinstein LS. Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance. Endocrinology. 2004 Sep; 145 (145; 9; 2004 Sep):4094-102. [Full Text/Abstract]
Chen L, Faulhaber-Walter R, Wen Y, Huang Y, Mizel D, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J. Renal failure in mice with Gsalpha deletion in juxtaglomerular cells. Am J Nephrol. 2010; 32 (32; 2010; 1):83-94. [Full Text/Abstract]