U.S. Department of Health and Human Services
Nicholas Guydosh

 Contact Info

Tel: 301-827-2051
Email: nicholas.guydosh@nih.gov

 Select Experience

  • Postdoctoral FellowJohns Hopkins University School of Medicine2009-2016
  • Ph.D.Stanford University2009
  • M.PhilUniversity of Cambridge2003
  • A.B.Harvard University2001

 Related Links


Nicholas R. Guydosh, Ph.D., Stadtman Tenure-Track Investigator

Acting Section Chief, Section on mRNA Regulation and TranslationLaboratory of Biochemistry and Genetics
  • Biomedical Engineering/Biophysics/Physics
  • Computational Biology/Bioinformatics/Biostatistics/Mathematics
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Virology


A selection of recent and significant publications can be viewed below.

Guydosh NR, Kimmig P, Walter P, Green R. Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. Elife. 2017 Sep 25; 6 (6; 2017 Sep 25). [Full Text/Abstract]
de Vasconcellos JF, Tumburu L, Byrnes C, Lee YT, Xu PC, Li M, Rabel A, Clarke BA, Guydosh NR, Proia RL, Miller JL. IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts. Proc Natl Acad Sci U S A. 2017 Jun 26; 114 (2017 Jun 26; 28; 114):E5664-E5672. [Full Text/Abstract]
Guydosh NR, Green R. Translation of poly(A) tails leads to precise mRNA cleavage. RNA. 2017 Feb 13; 23 (23; 2017 Feb 13; 5):749-761. [Full Text/Abstract]
Young DJ, Guydosh NR. Silence without stress. Elife. 2016 Nov 11; 5 (2016 Nov 11; 5). [Full Text/Abstract]
Young DJ, Guydosh NR, Zhang F, Hinnebusch AG, Green R. Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo. Cell. 2015 Aug 13; 162 (4; 162; 2015 Aug 13):872-84. [Full Text/Abstract]
Andreasson JO, Milic B, Chen GY, Guydosh NR, Hancock WO, Block SM. Examining kinesin processivity within a general gating framework. Elife. 2015 Apr 22; 4 (2015 Apr 22; 4). [Full Text/Abstract]
Woolstenhulme CJ, Guydosh NR, Green R, Buskirk AR. High-precision analysis of translational pausing by ribosome profiling in bacteria lacking EFP. Cell Rep. 2015 Apr 7; 11 (2015 Apr 7; 11; 1):13-21. [Full Text/Abstract]
Guydosh NR, Green R. Dom34 rescues ribosomes in 3' untranslated regions. Cell. 2014 Feb 27; 156 (156; 2014 Feb 27; 5):950-62. [Full Text/Abstract]
Woolstenhulme CJ, Parajuli S, Healey DW, Valverde DP, Petersen EN, Starosta AL, Guydosh NR, Johnson WE, Wilson DN, Buskirk AR. Nascent peptides that block protein synthesis in bacteria. Proc Natl Acad Sci U S A. 2013 Mar 5; 110 (110; 10; 2013 Mar 5):E878-87. [Full Text/Abstract]
Guydosh NR, Block SM. Direct observation of the binding state of the kinesin head to the microtubule. Nature. 2009 Sep 3; 461 (461; 2009 Sep 3; 7260):125-8. [Full Text/Abstract]
Valentine MT, Guydosh NR, Gutiérrez-Medina B, Fehr AN, Andreasson JO, Block SM. Precision steering of an optical trap by electro-optic deflection. Opt Lett. 2008 Mar 15; 33 (6; 33; 2008 Mar 15):599-601. [Full Text/Abstract]
Guydosh NR, Block SM. Not so lame after all: kinesin still walks with a hobbled head. J Gen Physiol. 2007 Nov; 130 (130; 2007 Nov; 5):441-4. [Full Text/Abstract]
Block SM, Larson MH, Greenleaf WJ, Herbert KM, Guydosh NR, Anthony PC. Molecule by molecule, the physics and chemistry of life: SMB 2007. Nat Chem Biol. 2007 Apr; 3 (2007 Apr; 4; 3):193-7. [Full Text/Abstract]
Guydosh NR, Block SM. Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain. Proc Natl Acad Sci U S A. 2006 May 23; 103 (2006 May 23; 21; 103):8054-9. [Full Text/Abstract]
Gianni S, Guydosh NR, Khan F, Caldas TD, Mayor U, White GW, DeMarco ML, Daggett V, Fersht AR. Unifying features in protein-folding mechanisms. Proc Natl Acad Sci U S A. 2003 Nov 11; 100 (100; 23; 2003 Nov 11):13286-91. [Full Text/Abstract]
Mayor U, Guydosh NR, Johnson CM, Grossmann JG, Sato S, Jas GS, Freund SM, Alonso DO, Daggett V, Fersht AR. The complete folding pathway of a protein from nanoseconds to microseconds. Nature. 2003 Feb 20; 421 (6925; 421; 2003 Feb 20):863-7. [Full Text/Abstract]