U.S. Department of Health and Human Services
Paolo Piaggi

 Contact Info

Tel: 602-440-6584
Email: paolo.piaggi@nih.gov

 Select Experience

  • Visiting FellowNIDDK2012-2016
  • Special VolunteerNIDDK2011-2012
  • Ph.D. in Automation, Robotics and BioengineeringUniversity of Pisa2012
  • M.S. in Biomedical EngineeringUniversity of Pisa2008
  • B.S. in Biomedical EngineeringUniversity of Pisa2006

 Related Links

  • Biomedical Engineering/Biophysics/Physics
  • Clinical Research
  • Computational Biology/Bioinformatics/Biostatistics/Mathematics
  • Epidemiology/Population Sciences
  • Genetics/Genomics


A selection of recent and significant publications can be viewed below.

Heinitz S, Reinhardt M, Piaggi P, Weise CM, Diaz E, Stinson EJ, Venti C, Votruba SB, Wassermann EM, Alonso-Alonso M, Krakoff J, Gluck ME. Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial. Am J Clin Nutr. 2017 Oct 18; 106 (106; 6; 2017 Oct 18):1347-1357. [Full Text/Abstract]
Denaro M, Ugolini C, Poma AM, Borrelli N, Materazzi G, Piaggi P, Chiarugi M, Miccoli P, Vitti P, Basolo F. Differences in miRNA expression profiles between wild-type and mutated NIFTPs. Endocr Relat Cancer. 2017 Oct; 24 (2017 Oct; 10; 24):543-553. [Full Text/Abstract]
Heinitz S, Piaggi P, Bogardus C, Krakoff J. Decline in the acute insulin response in relationship to plasma glucose concentrations. Diabetes Metab Res Rev. 2017 Sep 25; (2017 Sep 25). [Full Text/Abstract]
Di Bella G, Camastra G, Monti L, Dellegrottaglie S, Piaggi P, Moro C, Pepe A, Lanzillo C, Pontone G, Perazzolo Marra M, Di Roma M, Scatteia A, Aquaro GD, working group ‘Cardiac Magnetic Resonance’ of the Italian Society of Cardiology. Left and right ventricular morphology, function and late gadolinium enhancement extent and localization change with different clinical presentation of acute myocarditis Data from the ITAlian multicenter study on MYocarditis (ITAMY). J Cardiovasc Med (Hagerstown). 2017 Sep 14; 18 (2017 Sep 14; 11; 18):881-887. [Full Text/Abstract]
Piaggi P, Vinales KL, Basolo A, Santini F, Krakoff J. Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms. J Endocrinol Invest. 2017 Jul 24; (2017 Jul 24). [Full Text/Abstract]
Chang DC, Piaggi P, Hanson RL, Knowler WC, Bogardus C, Krakoff J. Autoantibodies against PFDN2 are associated with an increased risk of type 2 diabetes: A case-control study. Diabetes Metab Res Rev. 2017 Jul 21; 33 (8; 33; 2017 Jul 21). [Full Text/Abstract]
Di Bella G, Pizzino F, Aquaro GD, Piaggi P, Venuti G, Carerj S, Pingitore A. High-risk patients with mild-moderate left ventricular dysfunction after a previous myocardial infarction. A long-term prognostic data by cardiac magnetic resonance. Int J Cardiol. 2017 Jul 20; 245 (245; 2017 Jul 20):13-19. [Full Text/Abstract]
Paddock E, Hohenadel MG, Piaggi P, Vijayakumar P, Hanson RL, Knowler WC, Krakoff J, Chang DC. One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in Southwestern Native Americans. Diabetologia. 2017 Jun 29; 60 (60; 2017 Jun 29; 9):1704-1711. [Full Text/Abstract]
Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R. Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage. Int J Obes (Lond). 2017 Jun 13; 41 (2017 Jun 13; 41; 10):1585-1593. [Full Text/Abstract]
Chang DC, Piaggi P, Krakoff J. A Novel Approach to Predict 24-Hour Energy Expenditure Based on Hematologic Volumes: Development and Validation of Models Comparable to Mifflin-St Jeor and Body Composition Models. J Acad Nutr Diet. 2017 May 29; 117 (2017 May 29; 8; 117):1177-1187. [Full Text/Abstract]
Marabotti C, Piaggi P, Scarsi P, Venturini E, Cecchi R, Pingitore A. Mortality for chronic-degenerative diseases in Tuscany: Ecological study comparing neighboring areas with substantial differences in environmental pollution. Int J Occup Med Environ Health. 2017 May 24; 30 (30; 4; 2017 May 24):641-653. [Full Text/Abstract]
Piaggi P, Masindova I, Muller YL, Mercader J, Wiessner GB, Chen P, SIGMA Type 2 Diabetes Consortium., Kobes S, Hsueh WC, Mongalo M, Knowler WC, Krakoff J, Hanson RL, Bogardus C, Baier LJ. A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians. Diabetes. 2017 May 5; 66 (2017 May 5; 66; 8):2284-2295. [Full Text/Abstract]
Guidi G, Casini G, Ripandelli G, Piaggi P, Dalle Lucche F, Sartini M, Loiudice P, Nasini F, Stirpe M, Lazzeri S. RESIDUAL INTRARETINAL EDEMA AFTER 25-GAUGE VITRECTOMY AND MACULAR PUCKER REMOVAL: Is Intraoperative Sustained-release Dexamethasone a Real Treatment Option?. Retina. 2017 Apr 3; (2017 Apr 3). [Full Text/Abstract]
Chen P, Piaggi P, Traurig M, Bogardus C, Knowler WC, Baier LJ, Hanson RL. Differential methylation of genes in individuals exposed to maternal diabetes in utero. Diabetologia. 2017 Jan 26; 60 (2017 Jan 26; 4; 60):645-655. [Full Text/Abstract]
Reinhardt M, Piaggi P, DeMers B, Trinidad C, Krakoff J. Cross calibration of two dual-energy X-ray densitometers and comparison of visceral adipose tissue measurements by iDXA and MRI. Obesity (Silver Spring). 2016 Dec 21; 25 (25; 2016 Dec 21; 2):332-337. [Full Text/Abstract]
Matrone A, Gambale C, Piaggi P, Viola D, Giani C, Agate L, Bottici V, Bianchi F, Materazzi G, Vitti P, Molinaro E, Elisei R. Postoperative Thyroglobulin and Neck Ultrasound in the Risk Restratification and Decision to Perform 131I Ablation. J Clin Endocrinol Metab. 2016 Dec 8; 102 (2016 Dec 8; 102; 3):893-902. [Full Text/Abstract]
Weise CM, Piaggi P, Reinhardt M, Chen K, Savage CR, Krakoff J, Pleger B. The obese brain as a heritable phenotype: a combined morphometry and twin study. Int J Obes (Lond). 2016 Dec 5; 41 (2016 Dec 5; 41; 3):458-466. [Full Text/Abstract]
Frankl J, Piaggi P, Foley JE, Krakoff J, Votruba SB. In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans. Obesity (Silver Spring). 2016 Nov 21; 25 (25; 2016 Nov 21; 1):207-214. [Full Text/Abstract]
Muller YL, Piaggi P, Chen P, Wiessner G, Okani C, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ. Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3. Diabetes Metab Res Rev. 2016 Nov 8; 33 (33; 2016 Nov 8; 4). [Full Text/Abstract]
Vinales KL, Schlögl M, Piaggi P, Hohenadel M, Graham A, Bonfiglio S, Krakoff J, Thearle MS. The Consistency in Macronutrient Oxidation and the Role for Epinephrine in the Response to Fasting and Overfeeding. J Clin Endocrinol Metab. 2016 Nov 7; 102 (2016 Nov 7; 102; 1):279-289. [Full Text/Abstract]
Rago T, Scutari M, Loiacono V, Santini F, Tonacchera M, Torregrossa L, Giannini R, Borrelli N, Proietti A, Basolo F, Miccoli P, Piaggi P, Latrofa F, Vitti P. Low Elasticity of Thyroid Nodules on Ultrasound Elastography Is Correlated with Malignancy, Degree of Fibrosis, and High Expression of Galectin-3 and Fibronectin-1. Thyroid. 2016 Nov 3; 27 (27; 2016 Nov 3; 1):103-110. [Full Text/Abstract]
Chang DC, Piaggi P, Burkholder JE, Votruba SB, Krakoff J, Gluck ME. Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task. Physiol Behav. 2016 Oct 13; 167 (2016 Oct 13; 167):392-398. [Full Text/Abstract]
Di Bella G, Pingitore A, Piaggi P, Pizzino F, Barison A, Terrizzi A, d'angelo M, Todiere G, Quattrocchi S, Carerj S, Emdin M, Aquaro GD. Usefulness of late gadolinium enhancement MRI combined with stress imaging in predictive significant coronary stenosis in new-diagnosed left ventricular dysfunction. Int J Cardiol. 2016 Sep 19; 224 (2016 Sep 19; 224):337-342. [Full Text/Abstract]
Torregrossa L, Viola D, Sensi E, Giordano M, Piaggi P, Romei C, Materazzi G, Miccoli P, Elisei R, Basolo F. Papillary Thyroid Carcinoma With Rare Exon 15 BRAF Mutation Has Indolent Behavior: A Single-Institution Experience. J Clin Endocrinol Metab. 2016 Aug 29; 101 (101; 2016 Aug 29; 11):4413-4420. [Full Text/Abstract]
Hohenadel MG, Baier LJ, Piaggi P, Muller YL, Hanson RL, Krakoff J, Thearle MS. The impact of genetic variants on BMI increase during childhood versus adulthood. Int J Obes (Lond). 2016 Aug; 40 (2016 Aug; 40; 8):1301-9. [Full Text/Abstract]
Di Bella G, Minutoli F, Piaggi P, Casale M, Mazzeo A, Zito C, Oreto G, Baldari S, Vita G, Pingitore A, Khandheria BK, Carerj S. Quantitative Comparison Between Amyloid Deposition Detected by (99m)Tc-Diphosphonate Imaging and Myocardial Deformation Evaluated by Strain Echocardiography in Transthyretin-Related Cardiac Amyloidosis. Circ J. 2016 Aug 1; 80 (80; 2016 Aug 1; 9):1998-2003. [Full Text/Abstract]
Romei C, Casella F, Tacito A, Bottici V, Valerio L, Viola D, Cappagli V, Matrone A, Ciampi R, Piaggi P, Ugolini C, Torregrossa L, Basolo F, Materazzi G, Vitti P, Elisei R. New insights in the molecular signature of advanced medullary thyroid cancer: evidence of a bad outcome of cases with double RET mutations. J Med Genet. 2016 Jul 28; (2016 Jul 28). [Full Text/Abstract]
Salvetti G, Di Salvo C, Ceccarini G, Abramo A, Fierabracci P, Magno S, Piaggi P, Vitti P, Santini F. Chronic Renin-Angiotensin System (RAS) Blockade May Not Induce Hypotension During Anaesthesia for Bariatric Surgery. Obes Surg. 2016 Jun; 26 (6; 2016 Jun; 26):1303-7. [Full Text/Abstract]
Latrofa F, Ricci D, Sisti E, Piaggi P, Nencetti C, Marinò M, Vitti P. Significance of Low Levels of Thyroglobulin Autoantibodies Associated with Undetectable Thyroglobulin After Thyroidectomy for Differentiated Thyroid Carcinoma. Thyroid. 2016 Jun; 26 (6; 2016 Jun; 26):798-806. [Full Text/Abstract]
Ripandelli G, Rossi T, Cacciamani A, Scarinci F, Piaggi P, Stirpe M. LASER PROPHYLACTIC TREATMENT OF THE FELLOW EYE IN GIANT RETINAL TEARS: Long-Term Follow-up. Retina. 2016 May; 36 (2016 May; 36; 5):962-6. [Full Text/Abstract]
Fierabracci P, Martinelli S, Tamberi A, Piaggi P, Basolo A, Pelosini C, Ricco I, Magno S, Querci G, Ceccarini G, Scartabelli G, Salvetti G, Vitti P, Santini F. Weight Loss and Variation of Levothyroxine Requirements in Hypothyroid Obese Patients After Bariatric Surgery. Thyroid. 2016 Apr; 26 (2016 Apr; 4; 26):499-503. [Full Text/Abstract]
Nair AK, Piaggi P, McLean NA, Kaur M, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ. Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians. Diabetologia. 2016 Mar; 59 (2016 Mar; 59; 3):481-91. [Full Text/Abstract]
Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. Diabetes. 2016 Feb; 65 (2; 2016 Feb; 65):510-9. [Full Text/Abstract]
Lazzeri S, Orlandi P, Piaggi P, Sartini MS, Casini G, Guidi G, Figus M, Fioravanti A, Di Desidero T, Ripandelli G, Parravano M, Varano M, Nardi M, Bocci G. IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration. Pharmacogenomics. 2016; 17 (2016; 17; 1):35-9. [Full Text/Abstract]
de Bortoli N, Martinucci I, Savarino EV, Frazzoni M, Tutuian R, Tolone S, Piaggi P, Furnari M, Russo S, Bertani L, Macchia L, Savarino V, Marchi S. Manually calculated oesophageal bolus clearance time increases in parallel with reflux severity at impedance-pH monitoring. Dig Liver Dis. 2015 Dec; 47 (12; 2015 Dec; 47):1027-32. [Full Text/Abstract]
Schlögl M, Piaggi P, Pannacciuli N, Bonfiglio SM, Krakoff J, Thearle MS. Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change. Diabetes. 2015 Nov; 64 (64; 2015 Nov; 11):3680-9. [Full Text/Abstract]
Gluck ME, Alonso-Alonso M, Piaggi P, Weise CM, Jumpertz-von Schwartzenberg R, Reinhardt M, Wassermann EM, Venti CA, Votruba SB, Krakoff J. Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and weight loss in obesity. Obesity (Silver Spring). 2015 Nov; 23 (23; 2015 Nov; 11):2149-56. [Full Text/Abstract]
Piaggi P, Thearle MS, Krakoff J, Votruba SB. Higher Daily Energy Expenditure and Respiratory Quotient, Rather Than Fat-Free Mass, Independently Determine Greater ad Libitum Overeating. J Clin Endocrinol Metab. 2015 Aug; 100 (100; 8; 2015 Aug):3011-20. [Full Text/Abstract]
Piaggi P, Thearle MS, Bogardus C, Krakoff J. Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate. J Clin Endocrinol Metab. 2015 Mar; 100 (100; 3; 2015 Mar):1078-87. [Full Text/Abstract]
Votruba SB, Thearle MS, Piaggi P, Knowler WC, Hanson RL, Krakoff J. Weight maintenance from young adult weight predicts better health outcomes. Obesity (Silver Spring). 2014 Nov; 22 (2014 Nov; 22; 11):2361-9. [Full Text/Abstract]
Muller YL, Thearle MS, Piaggi P, Hanson RL, Hoffman D, Gene B, Mahkee D, Huang K, Kobes S, Votruba S, Knowler WC, Bogardus C, Baier LJ. Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children. Hum Genet. 2014 Nov; 133 (133; 2014 Nov; 11):1431-41. [Full Text/Abstract]
Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C. Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure. Diabetologia. 2014 Jul; 57 (7; 2014 Jul; 57):1382-90. [Full Text/Abstract]
Schlögl M, Piaggi P, Thiyyagura P, Reiman EM, Chen K, Lutrin C, Krakoff J, Thearle MS. Overfeeding over 24 hours does not activate brown adipose tissue in humans. J Clin Endocrinol Metab. 2013 Dec; 98 (2013 Dec; 98; 12):E1956-60. [Full Text/Abstract]
Piaggi P, Krakoff J, Bogardus C, Thearle MS. Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity. Diabetes. 2013 Dec; 62 (2013 Dec; 12; 62):4043-51. [Full Text/Abstract]