U.S. Department of Health and Human Services
Peggy Hsieh

 Contact Info

Tel: +1-301-496-0306
Email: peggyh@niddk.nih.gov

 Select Experience

  • Ph.D.Massachusetts Institute of Technology1983
  • B.A.Princeton University1979

 Related Links


Peggy Hsieh, Ph.D.

Section Chief, Genome Dynamics SectionGenetics and Biochemistry Branch
  • Cancer Biology
  • Chromosome Biology/Epigenetics
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Geng H, Hsieh P. Molecular Mechanisms and Functions of DNA Mismatch Repair. 2013; (2013). [Full Text/Abstract]
Hsieh P. DNA Mismatch Repair in Disease and Ageing. 2013; 2 (2; 2013):60-65. [Full Text/Abstract]
Hsieh, P. DNA Mismatch Repair: Dr. Jekyll and Mr. Hyde?. Molecular Cell. 9/14/2012; 47 (9/14/2012; 5; 47):665-666. [Full Text/Abstract]
Geng H, Sakato M, DeRocco V, Yamane K, Du C, Erie DA, Hingorani M, Hsieh P. Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D). J Biol Chem. 2012 Mar 23; 287 (287; 13; 2012 Mar 23):9777-91. [Full Text/Abstract]
Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med. 2011 Sep 25; 17 (17; 2011 Sep 25; 10):1298-303. [Full Text/Abstract]
Geng H, Du C, Chen S, Salerno V, Manfredi C, Hsieh P. In vitro studies of DNA mismatch repair proteins. Anal Biochem. 2011 Jun 15; 413 (2; 413; 2011 Jun 15):179-84. [Full Text/Abstract]
Tessmer I, Yang Y, Zhai J, Du C, Hsieh P, Hingorani MM, Erie DA. Mechanism of MutS searching for DNA mismatches and signaling repair. J Biol Chem. 2008 Dec 26; 283 (2008 Dec 26; 283; 52):36646-54. [Full Text/Abstract]
Liu A, Yoshioka K, Salerno V, Hsieh P. The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine. J Cell Biochem. 2008 Sep 1; 105 (105; 1; 2008 Sep 1):245-54. [Full Text/Abstract]
Hsieh P, Yamane K. DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev. 2008 Jul-Aug; 129 (2008 Jul-Aug; 129; 7-8):391-407. [Full Text/Abstract]
Yoshioka K, Yoshioka Y, Hsieh P. ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell. 2006 May 19; 22 (2006 May 19; 4; 22):501-10. [Full Text/Abstract]
Wang H, Yang Y, Schofield MJ, Du C, Fridman Y, Lee SD, Larson ED, Drummond JT, Alani E, Hsieh P, Erie DA. DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc Natl Acad Sci U S A. 2003 Dec 9; 100 (25; 2003 Dec 9; 100):14822-7. [Full Text/Abstract]
Obmolova G, Ban C, Hsieh P, Yang W. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature. 2000 Oct 12; 407 (6805; 2000 Oct 12; 407):703-10. [Full Text/Abstract]
Grigoriev M, Hsieh P. Migration of a Holliday junction through a nucleosome directed by the E. coli RuvAB motor protein. Mol Cell. 1998 Sep; 2 (2; 3; 1998 Sep):373-81. [Full Text/Abstract]
Panyutin IG, Hsieh P. The kinetics of spontaneous DNA branch migration. Proc Natl Acad Sci U S A. 1994 Mar 15; 91 (1994 Mar 15; 6; 91):2021-5. [Full Text/Abstract]