I joined NIDDK to establish the new Clinical Mass Spectrometry Core (CMSC). The CMSC’s mission is to support all stable isotope applications in NIDDK’s clinical labs and to advise, develop, and validate novel stable isotope-labeled research assays in collaboration with ongoing clinical research projects. Our primary emphasis is on the clinical measurement of total energy expenditure (TEE) by doubly labeled water (DLW). TEE is the total energy a person or animal uses in a day for rest and daily activities. TEE is an important calculation used in determining a person’s or animal’s dietary and exercise needs. It has been used extensively in obesity research.
The core’s secondary emphasis is the measurement of metabolic parameters, for example, using stable isotopes tracers and non-labeled metabolic tracers. The core’s tertiary emphasis is quantitative measurement of various metabolic componds through gas chromatography–mass spectrometry and liquid chromatography–mass spectrometry.