U.S. Department of Health and Human Services

 Contact Info

Tel: 301-435-6034
Email: philipa@mail.nih.gov

 Select Experience

  • Senior Biomedical Research ScientistLaboratory of Chemical Physics, NIDDK, NIH1998
  • Visiting ScientistEuropean Synchrotron and Radiation Facility1997
  • Associate Professor of ChemistryHarvard Univeristy1995
  • Assistant Professor of ChemistryHarvard Univeristy1990
  • Ph.D.Iowa State University1987
  • B.S.North Dakota State University1981

 Related Links


    • Biomedical Engineering/Biophysics/Physics
    • Structural Biology


    A selection of recent and significant publications can be viewed below.

    Kaila VR, Schotte F, Cho HS, Hummer G, Anfinrud PA. Contradictions in X-ray structures of intermediates in the photocycle of photoactive yellow protein. Nat Chem. 2014 Apr; 6 (6; 4; 2014 Apr):258-9. [Full Text/Abstract]
    Cho HS, Schotte F, Dashdorj N, Kyndt J, Anfinrud PA. Probing anisotropic structure changes in proteins with picosecond time-resolved small-angle X-ray scattering. J Phys Chem B. 2013 Dec 12; 117 (49; 117; 2013 Dec 12):15825-32. [Full Text/Abstract]
    Schotte F, Cho HS, Soman J, Wulff M, Olson JS, Anfinrud PA. Real-time tracking of CO migration and binding in the α and β subunits of human hemoglobin via 150-ps time-resolved Laue crystallography. Chem Phys. 2013 Aug 30; 422 (422; 2013 Aug 30):98-106. [Full Text/Abstract]
    Schotte F, Cho HS, Kaila VR, Kamikubo H, Dashdorj N, Henry ER, Graber TJ, Henning R, Wulff M, Hummer G, Kataoka M, Anfinrud PA. Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography. Proc Natl Acad Sci U S A. 2012 Nov 20; 109 (109; 2012 Nov 20; 47):19256-61. [Full Text/Abstract]
    Cho HS, Dashdorj N, Schotte F, Graber T, Henning R, Anfinrud P. Protein structural dynamics in solution unveiled via 100-ps time-resolved x-ray scattering. Proc Natl Acad Sci U S A. 2010 Apr 20; 107 (2010 Apr 20; 107; 16):7281-6. [Full Text/Abstract]
    Cammarata M, Eybert L, Ewald F, Reichenbach W, Wulff M, Anfinrud P, Schotte F, Plech A, Kong Q, Lorenc M, Lindenau B, Räbiger J, Polachowski S. Chopper system for time resolved experiments with synchrotron radiation. Rev Sci Instrum. 2009 Jan; 80 (2009 Jan; 80; 1):015101. [Full Text/Abstract]
    Cammarata M, Levantino M, Schotte F, Anfinrud PA, Ewald F, Choi J, Cupane A, Wulff M, Ihee H. Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering. Nat Methods. 2008 Oct; 5 (2008 Oct; 10; 5):881-6. [Full Text/Abstract]
    Aranda R 4th, Levin EJ, Schotte F, Anfinrud PA, Phillips GN Jr. Time-dependent atomic coordinates for the dissociation of carbon monoxide from myoglobin. Acta Crystallogr D Biol Crystallogr. 2006 Jul; 62 (Pt 7; 62; 2006 Jul):776-83. [Full Text/Abstract]
    Bourgeois D, Vallone B, Arcovito A, Sciara G, Schotte F, Anfinrud PA, Brunori M. Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography. Proc Natl Acad Sci U S A. 2006 Mar 28; 103 (2006 Mar 28; 13; 103):4924-9. [Full Text/Abstract]
    Anfinrud P, Schotte F. Chemistry. X-ray fingerprinting of chemical intermediates in solution. Science. 2005 Aug 19; 309 (309; 2005 Aug 19; 5738):1192-3. [Full Text/Abstract]
    Ihee H, Rajagopal S, Srajer V, Pahl R, Anderson S, Schmidt M, Schotte F, Anfinrud PA, Wulff M, Moffat K. Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. Proc Natl Acad Sci U S A. 2005 May 17; 102 (2005 May 17; 20; 102):7145-50. [Full Text/Abstract]
    Lim M, Anfinrud PA. Ultrafast time-resolved IR studies of protein-ligand interactions. Methods Mol Biol. 2005; 305 (2005; 305):243-60. [Full Text/Abstract]
    Hummer G, Schotte F, Anfinrud PA. Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations. Proc Natl Acad Sci U S A. 2004 Oct 26; 101 (2004 Oct 26; 43; 101):15330-4. [Full Text/Abstract]
    Schotte F, Soman J, Olson JS, Wulff M, Anfinrud PA. Picosecond time-resolved X-ray crystallography: probing protein function in real time. J Struct Biol. 2004 Sep; 147 (147; 3; 2004 Sep):235-46. [Full Text/Abstract]
    Lim M, Jackson TA, Anfinrud PA. Orientational distribution of CO before and after photolysis of MbCO and HbCO: a determination using time-resolved polarized Mid-IR spectroscopy. J Am Chem Soc. 2004 Jun 30; 126 (25; 126; 2004 Jun 30):7946-57. [Full Text/Abstract]
    Anderson S, Srajer V, Pahl R, Rajagopal S, Schotte F, Anfinrud P, Wulff M, Moffat K. Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein. Structure. 2004 Jun; 12 (2004 Jun; 6; 12):1039-45. [Full Text/Abstract]
    Plech A, Wulff M, Bratos S, Mirloup F, Vuilleumier R, Schotte F, Anfinrud PA. Visualizing chemical reactions in solution by picosecond x-ray diffraction. Phys Rev Lett. 2004 Mar 26; 92 (2004 Mar 26; 92; 12):125505. [Full Text/Abstract]
    Bourgeois D, Vallone B, Schotte F, Arcovito A, Miele AE, Sciara G, Wulff M, Anfinrud P, Brunori M. Complex landscape of protein structural dynamics unveiled by nanosecond Laue crystallography. Proc Natl Acad Sci U S A. 2003 Jul 22; 100 (100; 15; 2003 Jul 22):8704-9. [Full Text/Abstract]
    Schotte F, Lim M, Jackson TA, Smirnov AV, Soman J, Olson JS, Phillips GN Jr, Wulff M, Anfinrud PA. Watching a protein as it functions with 150-ps time-resolved x-ray crystallography. Science. 2003 Jun 20; 300 (300; 5627; 2003 Jun 20):1944-7. [Full Text/Abstract]
    Wullf M, Plech A, Eybert L, Randler R, Schotte F, Anfinrud P. The realization of sub-nanosecond pump and probe experiments at the ESRF. European Synchrotron Radiation Facility. Faraday Discuss. 2003; 122 (122; 2003):13-26; discussion 79-88. [Full Text/Abstract]