U.S. Department of Health and Human Services
Reed Wickner

 Contact Info

Tel: 301-496-3452
Email: wickner@helix.nih.gov

 Select Experience

  • M.D.Georgetown University1966
  • B.A.Cornell University1962

 Related Links


Reed B. Wickner, M.D., NIH Distinguished Investigator

Chief, Laboratory of Biochemistry and Genetics
Section Chief, Genetics of Simple Eukaryotes SectionLaboratory of Biochemistry and Genetics
  • Biophysics
  • Genetics/Genomics
  • Microbiology/Infectious diseases (non-viral)
  • Molecular Biology/Biochemistry
  • Prions
  • Virology


A selection of recent and significant publications can be viewed below.

Wickner RB, Kelly AC. Prions are affected by evolution at two levels. Cell Mol Life Sci. 2015 Dec 28; 73 (6; 2015 Dec 28; 73):1131-1144. [Full Text/Abstract]
Wickner RB, Shewmaker FP, Bateman DA, Edskes HK, Gorkovskiy A, Dayani Y, Bezsonov EE. Yeast prions: structure, biology, and prion-handling systems. Microbiol Mol Biol Rev. 2015 Mar; 79 (79; 1; 2015 Mar):1-17. [Full Text/Abstract]
Gorkovskiy A, Thurber KR, Tycko R, Wickner RB. Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid. Proc Natl Acad Sci U S A. 2014 Oct 13; 111 (43; 111; 2014 Oct 13):E4615-22. [Full Text/Abstract]
Groveman BR, Dolan MA, Taubner LM, Kraus A, Wickner RB, Caughey B. Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids. J Biol Chem. 2014 Jul 15; 289 (2014 Jul 15; 35; 289):24129-42. [Full Text/Abstract]
Edskes HK, Khamar HJ, Winchester CL, Greenler AJ, Zhou A, McGlinchey RP, Gorkovskiy A, Wickner RB. Sporadic distribution of prion-forming ability of sup35p from yeasts and fungi. Genetics. 2014 Jul 31; 198 (2; 198; 2014 Jul 31):605-16. [Full Text/Abstract]
Wickner RB, Bezsonov E, Bateman DA. Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants. Proc Natl Acad Sci U S A. 2014 Jul 1; 111 (2014 Jul 1; 111; 26):E2711-20. [Full Text/Abstract]
Kelly AC, Busby B, Wickner RB. Effect of domestication on the spread of the [PIN+] prion in Saccharomyces cerevisiae. Genetics. 2014 May 8; 197 (197; 3; 2014 May 8):1007-24. [Full Text/Abstract]
Wickner RB, Fujimura T, Esteban R. Viruses and prions of Saccharomyces cerevisiae. Adv Virus Res. 2013; 86 (86; 2013):1-36. [Full Text/Abstract]
Kelly AC, Shewmaker FP, Kryndushkin D, Wickner RB. Sex, prions, and plasmids in yeast. Proc Natl Acad Sci U S A. 2012 Oct 2; 109 (109; 40; 2012 Oct 2):E2683-90. [Full Text/Abstract]
Bateman DA, Wickner RB. [PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'. Genetics. 2012 Feb; 190 (2012 Feb; 190; 2):569-79. [Full Text/Abstract]
McGlinchey RP, Kryndushkin D, Wickner RB. Suicidal [PSI+] is a lethal yeast prion. Proc Natl Acad Sci U S A. 2011 Mar 29; 108 (108; 13; 2011 Mar 29):5337-41. [Full Text/Abstract]
Edskes HK, McCann LM, Hebert AM, Wickner RB. Prion variants and species barriers among Saccharomyces Ure2 proteins. Genetics. 2009 Mar; 181 (181; 3; 2009 Mar):1159-67. [Full Text/Abstract]
Kryndushkin DS, Shewmaker F, Wickner RB. Curing of the [URE3] prion by Btn2p, a Batten disease-related protein. EMBO J. 2008 Oct 22; 27 (20; 2008 Oct 22; 27):2725-35. [Full Text/Abstract]
Wickner RB, Shewmaker F, Kryndushkin D, Edskes HK. Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures. Bioessays. 2008 Oct; 30 (30; 2008 Oct; 10):955-64. [Full Text/Abstract]
Shewmaker F, Ross ED, Tycko R, Wickner RB. Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure. Biochemistry. 2008 Apr 1; 47 (2008 Apr 1; 13; 47):4000-7. [Full Text/Abstract]
Wickner RB, Dyda F, Tycko R. Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc Natl Acad Sci U S A. 2008 Feb 19; 105 (105; 2008 Feb 19; 7):2403-8. [Full Text/Abstract]
Baxa U, Wickner RB, Steven AC, Anderson DE, Marekov LN, Yau WM, Tycko R. Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance. Biochemistry. 2007 Nov 13; 46 (46; 2007 Nov 13; 45):13149-62. [Full Text/Abstract]
Ross ED, Minton A, Wickner RB. Prion domains: sequences, structures and interactions. Nat Cell Biol. 2005 Nov; 7 (7; 2005 Nov; 11):1039-44. [Full Text/Abstract]
Brachmann A, Baxa U, Wickner RB. Prion generation in vitro: amyloid of Ure2p is infectious. EMBO J. 2005 Sep 7; 24 (2005 Sep 7; 17; 24):3082-92. [Full Text/Abstract]
Ross ED, Edskes HK, Terry MJ, Wickner RB. Primary sequence independence for prion formation. Proc Natl Acad Sci U S A. 2005 Sep 6; 102 (102; 36; 2005 Sep 6):12825-30. [Full Text/Abstract]
Nakayashiki T, Kurtzman CP, Edskes HK, Wickner RB. Yeast prions [URE3] and [PSI+] are diseases. Proc Natl Acad Sci U S A. 2005 Jul 26; 102 (30; 102; 2005 Jul 26):10575-80. [Full Text/Abstract]
Pierce MM, Baxa U, Steven AC, Bax A, Wickner RB. Is the prion domain of soluble Ure2p unstructured?. Biochemistry. 2005 Jan 11; 44 (2005 Jan 11; 44; 1):321-8. [Full Text/Abstract]
Wickner RB, Edskes HK, Ross ED, Pierce MM, Baxa U, Brachmann A, Shewmaker F. Prion genetics: new rules for a new kind of gene. Annu Rev Genet. 2004; 38 (38; 2004):681-707. [Full Text/Abstract]
Baxa U, Taylor KL, Steven AC, Wickner RB. Prions of Saccharomyces and Podospora. Contrib Microbiol. 2004; 11 (2004; 11):50-71. [Full Text/Abstract]