Our research group is called the Gastrointestinal Cell Biology Section. We study hormones secreted by the stomach and intestine. These hormones help regulate digestion. We study how these hormones work at a cellular level. We also perform clinical and laboratory studies. In these studies, we focus on conditions in which the stomach releases too much gastric acid, a digestive fluid. One of these conditions is called Zollinger-Ellison syndrome.
Our research examines how cells receive and respond to digestive hormones. We study how their receptors trigger a cascade of reactions within the cell. We also investigate chemicals that bind to these receptors. We look at how their structure relates to their function. This research will help us develop agents that stimulate or block the receptors. Using that information, we are developing agents that bind only to specific receptors to treat tumors.
Our clinical studies involve patients with Zollinger-Ellison syndrome. In these studies, we focus on diagnosis, localization, and treatment of tumors. Our laboratory describes these tumors at the molecular level. The goal is to identify tumor characteristics that provide good information about patient outcomes.