Research on the Pima Indians in has greatly increased our understanding of type 2 diabetes. Our lab has been part of this effort since 1986, concentrating on the kidney complications caused by diabetes. What does the development and progression of diabetic kidney disease look like biologically? How can it be identified and, ultimately, arrested? These are the research questions that we study.
Our ability to prevent and treat disease relies on our understanding of when it is present and how it progresses. Scientists and clinicians rely on biomarkers—biological indicators that identify disease and disease progression. Our lab is working to characterize the changes in kidney structure and function that occur with diabetes and to identify biomarkers for diabetic kidney disease. A major part of our work is to better understand the role that specific genes and proteins play in the chain of chemical reactions that result in kidney injury and disease progression.