U.S. Department of Health and Human Services
Robert Tycko

 Contact Info

Tel: 301-402-8272
Email: robertty@mail.nih.gov

 Select Experience

  • Senior InvestigatorLCP, NIDDK, NIH1994-present
  • Member of Technical Staff (Principal Investigator)Physical Chemistry Research Department, AT&T Bell Laboratories1986-1994
  • Postdoctoral ResearcherUniversity of Pennsylvania1984-1986
  • Ph.D.University of California at Berkeley1984
  • A.B.Princeton University1980

 Related Links

  • Biomedical Engineering/Biophysics/Physics
  • Chemistry/Chemical Biology
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Qiang W, Yau WM, Lu JX, Collinge J, Tycko R. Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes. Nature. 2017 Jan 4; 541 (541; 7636; 2017 Jan 4):217-221. [Full Text/Abstract]
Bayro MJ, Ganser-Pornillos BK, Zadrozny KK, Yeager M, Tycko R. Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles. J Am Chem Soc. 2016 Sep 5; 138 (138; 2016 Sep 5; 37):12029-12032. [Full Text/Abstract]
Bayro MJ, Tycko R. Structure of the Dimerization Interface in the Mature HIV-1 Capsid Protein Lattice from Solid State NMR of Tubular Assemblies. J Am Chem Soc. 2016 Jun 14; 138 (138; 2016 Jun 14; 27):8538-46. [Full Text/Abstract]
Lu JX, Bayro MJ, Tycko R. Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments. J Biol Chem. 2016 Apr 19; 291 (291; 25; 2016 Apr 19):13098-112. [Full Text/Abstract]
Thurber K, Tycko R. Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning. J Magn Reson. 2016 Mar; 264 (264; 2016 Mar):99-106. [Full Text/Abstract]
Moore E, Tycko R. Micron-scale magnetic resonance imaging of both liquids and solids. J Magn Reson. 2015 Sep 8; 260 (2015 Sep 8; 260):1-9. [Full Text/Abstract]
Nagy-Smith K, Moore E, Schneider J, Tycko R. Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network. Proc Natl Acad Sci U S A. 2015 Aug 11; 112 (32; 2015 Aug 11; 112):9816-21. [Full Text/Abstract]
Potapov A, Yau WM, Ghirlando R, Thurber KR, Tycko R. Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization. J Am Chem Soc. 2015 Jun 12; 137 (25; 2015 Jun 12; 137):8294-307. [Full Text/Abstract]
Tycko R. Amyloid polymorphism: structural basis and neurobiological relevance. Neuron. 2015 May 6; 86 (2015 May 6; 86; 3):632-45. [Full Text/Abstract]
Tycko R. On the problem of resonance assignments in solid state NMR of uniformly ¹⁵N,¹³C-labeled proteins. J Magn Reson. 2015 Apr; 253 (2015 Apr; 253):166-72. [Full Text/Abstract]
Tycko R. Physical and structural basis for polymorphism in amyloid fibrils. Protein Sci. 2014 Sep 1; 23 (23; 11; 2014 Sep 1):1528-39. [Full Text/Abstract]
Tycko R. Remote sensing of sample temperatures in nuclear magnetic resonance using photoluminescence of semiconductor quantum dots. J Magn Reson. 2014 Jul; 244C (2014 Jul; 244C):64-67. [Full Text/Abstract]
Yau WM, Thurber KR, Tycko R. Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR. J Magn Reson. 2014 Jul; 244C (2014 Jul; 244C):98-106. [Full Text/Abstract]
Thurber KR, Tycko R. Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves. J Chem Phys. 2014 May 14; 140 (140; 2014 May 14; 18):184201. [Full Text/Abstract]
Bayro MJ, Chen B, Yau WM, Tycko R. Site-specific structural variations accompanying tubular assembly of the HIV-1 capsid protein. J Mol Biol. 2014 Mar 6; 426 (2014 Mar 6; 5; 426):1109-27. [Full Text/Abstract]
Lu JX, Qiang W, Yau WM, Schwieters CD, Meredith SC, Tycko R. Molecular Structure of β-Amyloid Fibrils in Alzheimer's Disease Brain Tissue. Cell. 2013 Sep 12; 154 (6; 2013 Sep 12; 154):1257-68. [Full Text/Abstract]
Tycko R, Wickner RB. Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy. Acc Chem Res. 2013 Jul 16; 46 (46; 7; 2013 Jul 16):1487-96. [Full Text/Abstract]
Qiang W, Kelley K, Tycko R. Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth. J Am Chem Soc. 2013 May 8; 135 (135; 18; 2013 May 8):6860-71. [Full Text/Abstract]
Thurber KR, Potapov A, Yau WM, Tycko R. Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K. J Magn Reson. 2013 Jan; 226 (226; 2013 Jan):100-6. [Full Text/Abstract]
Qiang W, Tycko R. Zero-quantum stochastic dipolar recoupling in solid state nuclear magnetic resonance. J Chem Phys. 2012 Sep 14; 137 (2012 Sep 14; 137; 10):104201. [Full Text/Abstract]
Thurber KR, Tycko R. Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings. J Chem Phys. 2012 Aug 28; 137 (2012 Aug 28; 8; 137):084508. [Full Text/Abstract]
Qiang W, Yau WM, Luo Y, Mattson MP, Tycko R. Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A. 2012 Mar 20; 109 (109; 2012 Mar 20; 12):4443-8. [Full Text/Abstract]
Chen B, Tycko R. Simulated self-assembly of the HIV-1 capsid: protein shape and native contacts are sufficient for two-dimensional lattice formation. Biophys J. 2011 Jun 22; 100 (2011 Jun 22; 100; 12):3035-44. [Full Text/Abstract]
Kryndushkin DS, Wickner RB, Tycko R. The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR. J Mol Biol. 2011 Jun 3; 409 (2; 2011 Jun 3; 409):263-77. [Full Text/Abstract]
Qiang W, Yau WM, Tycko R. Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J Am Chem Soc. 2011 Mar 23; 133 (2011 Mar 23; 133; 11):4018-29. [Full Text/Abstract]
Lu JX, Yau WM, Tycko R. Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein. Biophys J. 2011 Feb 2; 100 (100; 2011 Feb 2; 3):711-9. [Full Text/Abstract]
Tycko R, Savtchenko R, Ostapchenko VG, Makarava N, Baskakov IV. The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel β-sheet structure in PrP fibrils: evidence from solid state nuclear magnetic resonance. Biochemistry. 2010 Nov 9; 49 (49; 2010 Nov 9; 44):9488-97. [Full Text/Abstract]
Lu JX, Sharpe S, Ghirlando R, Yau WM, Tycko R. Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci. 2010 Oct; 19 (19; 2010 Oct; 10):1877-96. [Full Text/Abstract]
Thurber KR, Tycko R. Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization. Phys Chem Chem Phys. 2010 Jun 14; 12 (12; 2010 Jun 14; 22):5779-85. [Full Text/Abstract]
Chen B, Tycko R. Structural and dynamical characterization of tubular HIV-1 capsid protein assemblies by solid state nuclear magnetic resonance and electron microscopy. Protein Sci. 2010 Apr; 19 (19; 4; 2010 Apr):716-30. [Full Text/Abstract]
Hu KN, Yau WM, Tycko R. Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance. J Am Chem Soc. 2010 Jan 13; 132 (132; 2010 Jan 13; 1):24-5. [Full Text/Abstract]
Hu KN, Havlin RH, Yau WM, Tycko R. Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance. J Mol Biol. 2009 Oct 2; 392 (392; 4; 2009 Oct 2):1055-73. [Full Text/Abstract]
Paravastu AK, Leapman RD, Yau WM, Tycko R. Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A. 2008 Nov 25; 105 (105; 2008 Nov 25; 47):18349-54. [Full Text/Abstract]
Luca S, Yau WM, Leapman R, Tycko R. Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry. 2007 Nov 27; 46 (46; 2007 Nov 27; 47):13505-22. [Full Text/Abstract]
Tycko R. Symmetry-based constant-time homonuclear dipolar recoupling in solid state NMR. J Chem Phys. 2007 Feb 14; 126 (2007 Feb 14; 126; 6):064506. [Full Text/Abstract]
Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science. 2005 Jan 14; 307 (307; 5707; 2005 Jan 14):262-5. [Full Text/Abstract]