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U.S. Department of Health and Human Services
Robert Tycko

 Contact Info

Tel: 301-402-8272

 Select Experience

  • Senior InvestigatorLCP, NIDDK, NIH1994-present
  • Member of Technical Staff (Principal Investigator)Physical Chemistry Research Department, AT&T Bell Laboratories1986-1994
  • Postdoctoral ResearcherUniversity of Pennsylvania1984-1986
  • Ph.D.University of California at Berkeley1984
  • A.B.Princeton University1980

 Related Links

  • Biomedical Engineering/Biophysics/Physics
  • Chemistry/Chemical Biology
  • Structural Biology
Research Summary/In Plain Language

Research in Plain Language

We develop new methods for learning the structures of proteins and other molecules that play central roles in human disease.  We apply these methods to specific problems where more conventional methods are not adequate.  As an example, we developed detailed models of amyloid fibrils.  Amyloid fibrils may be linked to Alzheimer's disease and type 2 diabetes.  Our models reveal the molecular interactions that lead to amyloid fibrils.  This knowledge will inform the design of chemical compounds to inhibit fibril formation.